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(aldesleukin)
132 results
  • A novel therapeutic paradigm for patients with extensive alopecia areata. [Review]
  • EOExpert Opin Biol Ther 2016; 16(8):1005-14
  • Renert-Yuval Y, Guttman-Yassky E
  • CONCLUSIONS: The translational revolution leading to improved therapeutic strategies has just begun for AA. These treatments are often associated with better safety and higher efficacy compared to currently used immune-suppressants. Different pathways might drive the inflammatory process in AA. Ongoing and future clinical trials utilizing narrow- targeted therapeutics will be able to better elucidate the role of each cytokine pathway in creating the AA disease phenotype.
  • Dinutuximab: An Anti-GD2 Monoclonal Antibody for High-Risk Neuroblastoma. [Review]
  • APAnn Pharmacother 2016; 50(5):416-22
  • Ploessl C, Pan A, … Lowe DK
  • CONCLUSIONS: Dinutuximab is the first anti-GD2 monoclonal antibody approved in combination with GM-CSF, IL-2, and RA for maintenance treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to first-line multiagent, multimodality therapy. Ongoing research will determine if dinutuximab could be used earlier in treatment, in nonresponders to initial therapies, in combination with chemotherapy, or in other cancers.
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