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4,897 results
  • Effects of an oral bisphosphonate and three intravenous bisphosphonates on several cell types in vitro. [Journal Article]
  • COClin Oral Investig 2018 Feb 01
  • Jung J, Park JS, … Walter C
  • CONCLUSIONS: The incidence of BP-ONJ in oral bisphosphonate treatment is reported to be much lower than that in intravenous bisphosphonates. However, the influences of alendronate on human cells were at least as strong as ibandronate, although it was lower than zoledronate.Alendronate showed strong enough effects to suppress human somatic cells and was comparable to certain intravenous bisphosphonates in potency. This study suggests that the lower incidence of BP-ONJ in alendronate treatment is not originated by its potency, but might be due to the low bioavailability of alendronate, lower dosing on a daily basis, and having no additional therapies.
  • Osteoporosis: A Review of Treatment Options. [Journal Article]
  • P TP T 2018; 43(2):92-104
  • Tu KN, Lie JD, … Hyun D
  • Approximately 10 million men and women in the U.S. have osteoporosis,1 a metabolic bone disease characterized by low bone density and deterioration of bone architecture that increase the risk of frac...
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