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1,257 results
  • Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes. [Review]
    Nutrients 2019; 11(9)Infante M, Ricordi C, … Fabbri A
  • Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which geneti…
  • FGF23, Hypophosphatemia, and Emerging Treatments. [Review]
    JBMR Plus 2019; 3(8):e10190Imel EA, Biggin A, … Munns CF
  • FGF23 is an important hormonal regulator of phosphate homeostasis. Together with its co-receptor Klotho, it modulates phosphate reabsorption and both 1α-hydroxylation and 24-hydroxylation in the renal proximal tubules. The most common FGF23-mediated hypophosphatemia is X-linked hypophosphatemia (XLH), caused by mutations in the PHEX gene. FGF23-mediated forms of hypophosphatemia are characterized…
  • Lessons learned from the management of Hungry Bone Syndrome following the removal of an Atypical Parathyroid Adenoma. [Case Reports]
    J Musculoskelet Neuronal Interact 2019; 19(3):379-384Florakis D, Karakozis S, … Makras P
  • Hungry Bone Syndrome (HBS) refers to rapid, profound, and prolonged hypocalcemia associated with hypophosphatemia and hypomagnesemia occurring in patients with increased bone turnover after successful management of the underlying disorder. We describe a male patient with primary hyperparathyroidism (PHPT), in whom HBS was diagnosed 6 months after parathyroidectomy. Histopathologic examination rev…
  • Renalase in children with chronic kidney disease. [Journal Article]
    Biomarkers 2019; :1-7Skrzypczyk P, Okarska-Napierała M, … Pańczyk-Tomaszewska M
  • CONCLUSIONS: In children with CKD there is a strong correlation between renalase level and CKD stage. Furthermore, in these patients renalase does not correlate with blood pressure but may be a marker of arterial stiffness.
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