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573 results
  • Revisiting the pharmacodynamics uroselectivity of Alpha1-Adrenergic Receptor Antagonists. [Journal Article]
    J Pharmacol Exp Ther 2019Quaresma BMCS, Pimenta AR, … Noel F
  • α1-adrenoceptor (AR) antagonists are widely used for the relief of urinary retention secondary to benign prostatic hyperplasia (BPH). While the five FDA-approved α1-AR antagonists (terazosin, doxazosin, alfuzosin, tamsulosin and silodosin) share similar efficacy, they differ in tolerability with reports of ejaculatory dysfunction. The aim of the present work was to revisit their α1-AR subtype sel…
  • Successful reversal of isolated delayed spinal cord ischemia following endovascular abdominal aneurysm repair. [Case Reports]
    Vasc Health Risk Manag 2019; 15:81-87Aljarrah Q, Al-Omari MH, … Alzoubi A
  • A 74-year-old patient presented with isolated fecal incontinence 6 weeks following endovascular aneurysm repair. The delayed presentation of spinal cord ischemia was precipitated by commencement of alpha-blockers for benign prostatic hyperplasia. This case stresses that vulnerability to spinal cord perfusion is not limited to the perioperative period. In addition, systemic arterial pressure shoul…
  • Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin. [Journal Article]
    Neurogastroenterol Motil 2019; 31(7):e13618Muthyala A, Feuerhak KJ, … Bharucha AE
  • CONCLUSIONS: In healthy controls and DD patients, mental stressors likely increased anal pressure by contracting the internal anal sphincter; relaxation reduced anal pressure in DD patients. Alfuzosin reduced anal resting pressure but did not block the Stroop-mediated contractile response, which suggests that this response is not entirely mediated by adrenergic α1 receptors.
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