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579 results
  • Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review. [Review]
    World J Mens Health. 2020 Jan 02 [Online ahead of print]Yeung HEL, Sena SJ, … Woo HH
  • Studies have demonstrated that alfuzosin not only improves lower urinary tract symptoms (LUTS) but also appears to preserve ejaculatory dysfunction (EjD). The objective of this study was to evaluate the impact of alfuzosin on ejaculatory function using the 'Male Sexual Health Questionnaire (MSHQ)-EjD Short Form' - a validated, abridged-version of the 25-item MSHQ specifically assessing EjD. A sys…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Alpha 1 Adrenergic Receptor Antagonists [BOOK]
    . National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The alpha-1 adrenergic receptor antagonists (also called alpha-blockers) are a family of agents that bind to and inhibit type 1 alpha-adrenergic receptors and thus inhibit smooth muscle contraction. Their major uses are for hypertension and for symptomatic benign prostatic hypertrophy. Their use in therapy of hypertension is based on the inhibition of vascular resistance in arterioles from alpha-…
  • Revisiting the Pharmacodynamic Uroselectivity of α 1-Adrenergic Receptor Antagonists. [Journal Article]
    J Pharmacol Exp Ther. 2019 10; 371(1):106-112.Quaresma BMCS, Pimenta AR, … Noël F
  • α1-Adrenoceptor (AR) antagonists are widely used for the relief of urinary retention secondary to benign prostatic hyperplasia (BPH). While the five Food and Drug Administration-approved α 1-AR antagonists (terazosin, doxazosin, alfuzosin, tamsulosin, and silodosin) share similar efficacy, they differ in tolerability, with reports of ejaculatory dysfunction. The aim of the present work was to rev…
  • Successful reversal of isolated delayed spinal cord ischemia following endovascular abdominal aneurysm repair. [Case Reports]
    Vasc Health Risk Manag. 2019; 15:81-87.Aljarrah Q, Al-Omari MH, … Alzoubi A
  • A 74-year-old patient presented with isolated fecal incontinence 6 weeks following endovascular aneurysm repair. The delayed presentation of spinal cord ischemia was precipitated by commencement of alpha-blockers for benign prostatic hyperplasia. This case stresses that vulnerability to spinal cord perfusion is not limited to the perioperative period. In addition, systemic arterial pressure shoul…
  • Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin. [Randomized Controlled Trial]
    Neurogastroenterol Motil. 2019 07; 31(7):e13618.Muthyala A, Feuerhak KJ, … Bharucha AE
  • CONCLUSIONS: In healthy controls and DD patients, mental stressors likely increased anal pressure by contracting the internal anal sphincter; relaxation reduced anal pressure in DD patients. Alfuzosin reduced anal resting pressure but did not block the Stroop-mediated contractile response, which suggests that this response is not entirely mediated by adrenergic α1 receptors.
  • Is Tamsulosin Linked to Dementia in the Elderly? [Review]
    Curr Urol Rep. 2018 Jul 03; 19(9):69.Frankel JK, Duan Y, Albertsen PC
  • Lower urinary tract symptoms (LUTS) result from age-related changes in detrusor function and prostatic growth that are driven by alterations in the ratio of circulating androgens and estrogens. Alpha-adrenergic receptor blockers are commonly used to treat LUTS because they influence urethral tone and intra-urethral pressure. Molecular cloning studies have identified three α1-adrenergic receptor s…
  • New alpha blockers to treat male lower urinary tract symptoms. [Journal Article]
    Curr Opin Urol. 2018 05; 28(3):273-276.Hwang EC, Gandhi S, Jung JH
  • To date it is unclear whether the selectivity of new alpha-blockers to alpha-adrenergic receptor subtypes translates into more clinical benefits and less adverse effects in clinical practice. We performed a systematic review of the two new Abs silodosin and naftopidil. With the availability of numerous alpha-blockers to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia,…
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