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882 results
  • The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review. [Review]
    Int J Mol Sci. 2022 Oct 20; 23(20)Ramchatesingh B, Martínez Villarreal A, … Litvinov IV
  • Retinoids are natural and synthetic vitamin A derivatives that are effective for the prevention and the treatment of non-melanoma skin cancers (NMSC). NMSCs constitute a heterogenous group of non-melanocyte-derived skin cancers that impose substantial burdens on patients and healthcare systems. They include entities such as basal cell carcinoma and cutaneous squamous cell carcinoma (collectively …
  • Retinoid-associated myopia in dermatologic patients: a systematic review. [Case Reports]
    Cutan Ocul Toxicol. 2022 Dec; 41(4):318-322.Roccuzzo G, Tibaldi T, … Ribero S
  • CONCLUSIONS: Considering the current literature, it is not possible to define a clear correlation between the use of retinoids and the development or worsening of myopia. Some studies suggest that retinoids may cause a myopic shift and the pathophysiologyical mechanism is supported by some animal and in vitro studies, but there is a lack of large prospective and well-controlled studies. In case of ocular disturbances after retinoid use a prompt ophthalmological referral is advisable and in case of the detection of a myopic refractive error a relationship to retinoids should be ruled out, considering also other possible causes such as age and previous refractive status.
  • Retinoid-induced skeletal hyperostosis in disorders of keratinization. [Journal Article]
    Clin Exp Dermatol. 2022 Dec; 47(12):2273-2276.Doolan BJ, Paolino A, … Mellerio JE
  • For disorders of keratinization, topical treatment alone may be ineffective, and systemic retinoid therapy may be indicated. Treatment with systemic retinoids (acitretin, isotretinoin and alitretinoin) has been shown to be effective in reducing disease severity; however, potentially rare adverse effects (AEs) may occur, including hyperostotic skeletal changes. The true prevalence of this AE in ad…
  • Darier Disease with Psoriasis. [Case Reports]
    Medicina (Kaunas). 2022 Jul 06; 58(7)Kang SY, Lee SY, … Kim HO
  • Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 48-year-old male patient presented skin lesions with pruritus on the trunk and both upper and lower …
  • Treatments for AIDS/HIV-related Kaposi sarcoma: A systematic review of the literature. [Review]
    Int J Dermatol. 2022 Nov; 61(11):1311-1324.Liew YCC, Tam YCS, Oh CC
  • CONCLUSIONS: The evidence of efficacy of any particular intervention is overall varied and there was insufficient evidence to recommend any particular intervention. We have provided an overview of treatments for KS but larger studies need to be carried out to verify the efficacy of treatment options reported in the literature.
  • Alitretinoin for the treatment of severe chronic eczema of the hands. [Review]
    Expert Opin Pharmacother. 2022 Feb; 23(2):159-167.Napolitano M, Potestio L, … Patruno C
  • CONCLUSIONS: Alitretinoin can be considered as a valid therapeutic option for the treatment of CHE in patients not responding to ordinary treatments. Clinical trials and real-life experiences showed that it acts effectively on both objective and subjective clinical signs, resulting in a significant improvement in QoL of patients. As for other retinoids, caution should be taken in patients with certain chronic diseases (hepatopathies, kidney failure, hyperlipidemia, thyroid dysfunction) or childbearing potential women.
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