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(alpha1 proteinase inhibitor Human)
12,511 results
  • Alfa-1-antitrypsin deficiency: a predisposing factor leading to invasive infections? [Journal Article]
    Infect Dis (Lond) 2020; 52(2):130-134De Smet S, Dierick J, … Loof S
  • This case report highlights for the first time a possible link between the presence of alfa-1-antitrypsin deficiency (AATD) and the susceptibility to invasive infections. The current patient, with known AATD, initially presented with nausea, vomiting and headache secondary to Listeria monocytogenes rhombencephalitis. Further on, he developed respiratory insufficiency due to probable invasive pulm…
  • Production of α2,6-sialylated and non-fucosylated recombinant alpha-1-antitrypsin in CHO cells. [Journal Article]
    J Biotechnol 2020; 307:87-97Lalonde ME, Koyuturk I, … Durocher Y
  • Alpha-1-antitrypsin (A1AT) is an abundant serum inhibitor of serine proteases. A1AT deficiency is a common genetic disorder which is currently treated with augmentation therapies. These treatments involve weekly injections of patients with purified plasma-derived A1AT. Such therapies can be extremely expensive and rely on plasma donors. Hence, large-scale production of recombinant A1AT (rA1AT) co…
  • Genetic Causes of Liver Disease: When to Suspect a Genetic Etiology, Initial Lab Testing, and the Basics of Management. [Review]
    Med Clin North Am 2019; 103(6):991-1003Schonfeld EA, Brown RS
  • Genetic causes of liver disease lead to a wide range of presentations. This article describes hereditary hemochromatosis, Gilbert syndrome, alpha-1 antitrypsin deficiency, Wilson disease, PFIC, BRIC, and LAL-D. The most common cause of hereditary hemochromatosis is a C282Y mutation in the HFE gene. Gilbert syndrome is a benign cause of indirect hyperbilirubinemia. Alpha-1 antitrypsin deficiency c…
  • Experimental and investigational drugs for the treatment of alpha-1 antitrypsin deficiency. [Review]
    Expert Opin Investig Drugs 2019; 28(10):891-902Pye A, Turner AM
  • Introduction: Alpha-1 antitrypsin deficiency (AATD) is most often associated with chronic lung disease, early onset emphysema, and liver disease. The standard of care in lung disease due to AATD is alpha-1 antitrypsin augmentation but there are several new and emerging treatment options under investigation for both lung and liver manifestations. Areas covered: We review therapeutic approaches to …
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