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(alpha1 proteinase inhibitor Human)
12,458 results
  • Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice. [Journal Article]
    J Clin Med 2019; 8(9)Elshikha AS, Abboud G, … Song S
  • Diffuse alveolar hemorrhage (DAH) is a fatal complication in patients with lupus. DAH can be induced in B6 mice by an intraperitoneal injection of pristane. Since human alpha-1-antitrypsin (hAAT) is an anti-inflammatory and immuno-regulatory protein, we investigated the protective effect of hAAT against pristane-induced DAH in B6 mice and hAAT transgenic (hAAT-Tg) mice. We first showed that hAAT …
  • SERPINA1 gene polymorphisms in a population-based ALSPAC cohort. [Journal Article]
    Pediatr Pulmonol 2019; 54(9):1474-1478DeLuca DS, Poluzioroviene E, … Valiulis A
  • CONCLUSIONS: Analyzed SNPs in SERPINA1 are not associated with wheezing/asthma phenotypes. Only rs28929474, the most common pathologic SNP (Pi*Z) in the SERPINA1 gene, might be associated with a risk of developing school-age asthma without exhibiting preschool wheeze.
  • Comparison of α2,6-Sialyltransferases for sialylation of therapeutic proteins. [Journal Article]
    Glycobiology 2019Janesch B, Saxena H, … Wakarchuk WW
  • The development of therapeutic proteins for the treatment of numerous diseases is one of the fastest growing areas of biotechnology. Therapeutic efficacy and serum half-life are particularly important, and these properties rely heavily on the glycosylation state of the protein. Expression systems to produce authentically fully glycosylated therapeutic proteins with appropriate terminal sialic aci…
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