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(alpha1 proteinase inhibitor human)
12,094 results
  • Alpha-1 antitrypsin deficiency: From the lung to the heart? [Journal Article]
  • AAtherosclerosis 2018 Jan 31; 270:166-172
  • Curjuric I, Imboden M, … Probst-Hensch NM
  • CONCLUSIONS: Our results support a possible causal relationship between genetic A1AT deficiency and increased cardiovascular risk, which needs to be better taken into account for the management of affected patients and first-degree relatives.
  • Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema. [Journal Article]
  • AJAm J Respir Cell Mol Biol 2018 Feb 08
  • Joshi R, Heinz A, … Varisco BM
  • CONCLUSIONS: Cela1 is important in physiologic and pathologic stretch-dependent remodeling processes in the postnatal lung. AAT is an important regulator of this process. Our findings provide proof-of-concept for the development of anti-Cela1 therapies to prevent and/or treat AAT-deficient emphysema.
  • The Therapeutic Potential of Hyaluronan in COPD. [Journal Article]
  • ChestChest 2017 Dec 28
  • Turino GM, Ma S, … Cantor JO
  • Insights into the clinical course of COPD indicate the need for new therapies for this condition. The discovery of alpha-1 antitrypsin deficiency (AATD) led to the protease-antiprotease imbalance hyp...
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