Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(alpha thalassemia)
8,311 results
  • Lifting the iron curtain of vision. [Journal Article]
    EMBO Mol Med. 2023 Jan 30 [Online ahead of print]Rosin B, Sahel JA
  • Ocular and specifically retinal toxicities of systemic medications are prevalent and encompass many disease modalities. For many of these pharmaceuticals, established follow-up protocols are in place to ensure timely detection and cessation of therapy. However, while for some disorders, cessation of therapy is a viable option due to existing treatment alternatives, for some others cessation of tr…
  • Safety and Efficacy of Thalidomide and Hydroxyurea Combination in Beta Thalassemia Patients. [Journal Article]
    Indian J Hematol Blood Transfus. 2023 Jan; 39(1):85-89.Garg A, Patel K, … Shah S
  • Beta thalassemia results from imbalance in alpha and beta globin chains causing severe anemia, transfusion dependency, and iron overload. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment. Patients without the option of HSCT may benefit from Hemoglobin F (HbF) inducing agents like thalidomide and hydroxyurea (HU). We conducted a retrospective analysis on 87 beta thalas…
  • Clinical Perspective on Use of Long-Read Sequencing in Prenatal Diagnosis of Thalassemia. [Journal Article]
    Clin Chem. 2023 Jan 17 [Online ahead of print]Toledo DM, Lafferty KA
  • This is an editorial focusing on the clinical perspective of a long-read sequencing method in the prenatal diagnosis of alpha- and beta-thalassemia, including a comparison between this method and standard PCR-based methods. Though incremental, the increased sensitivity and specificity using long-read sequencing is an important advantage of this methodology in the prenatal diagnostic arena due to …
  • Impact of epigenetic reprogramming on antitumor immune responses in glioma. [Review]
    J Clin Invest. 2023 Jan 17; 133(2)McClellan BL, Haase S, … Castro MG
  • Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis, tumor progression, and responses to immunotherapies, as well as determining clinical features. This epigenetic remodeling includes changes in histone modifications, chromatin structure, and DNA methylation, all of whic…
  • Genetic Analysis of Alpha-Thalassemia Mutations in Thi-Gar Province, Iraq. [Journal Article]
    Arch Razi Inst. 2022 06; 77(3):976-980.Odah Al-Musawi AH, Jumaah Alhussna A, Hussein Jalood H
  • The prevalence of alpha-thalassemia as a major health problem in the south of Iraq has highlighted the necessity of investigations and screening of patients with thalassemia. The present study aimed to characterize the spectrum of alpha-globin gene mutations in patients who were followed up in a genetic diseases center in Thi-Qar province. A total of 30 subjects were collected from thalassemia pa…
  • Efficacy and Safety of Luspatercept in the Treatment of β-Thalassemia: A Systematic Review. [Review]
    Cureus. 2022 Nov; 14(11):e31570.Dighriri IM, Alrabghi KK, … Alharbi AA
  • β-thalassemia is characterized by the faulty generation of hemoglobin resulting in an elevated α/β globin ratio; this led to several patients needing red blood cell (RBC) transfusions for the rest of their lives. Luspatercept is an erythroid maturation test for treating various types of anemia, including β-thalassemia. It inhibits the Smad2/3 cascade and treats β-thalassemia by downregulating the…
New Search Next