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2,534 results
  • StatPearls [BOOK]
  • BOOKStatPearls Publishing: Treasure Island (FL)
  • Suddock Jolee T. JT University of New Mexico Cain Matthew D. MD University of New Mexico Hospital/Office of the Medical Investigator
  • Barbiturates are a class of sedative-hypnotic drugs. They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental). Some states administer barbitur...
  • A Systematic Review of Pharmacologic Treatments for School Refusal Behavior. [Journal Article]
  • JCJ Child Adolesc Psychopharmacol 2018 May 09
  • Londono Tobon A, Reed MO, … Bloch MH
  • CONCLUSIONS: Data regarding pharmacological treatments for school refusal are sparse. Most trials in this area were conducted before development of newer antidepressants, were underpowered, and have significant methodological limitations that are characteristic of the time in which they were conducted. This systematic review highlights the need for more trials with newer pharmacologic agents, larger sample sizes, and improved systematic assessments of school refusal and comorbidities. School refusal represents an important functional outcome for many children, especially those with anxiety and depression. Future pharmacologic studies of anxiety and depression in children may benefit from incorporating specific school refusal measures as secondary outcomes.
  • Evaluating drugged driving: Effects of exemplar pain and anxiety medications. [Journal Article]
  • TITraffic Inj Prev 2018 Feb 28; 19(sup1):S97-S103
  • Brown TL, Milavetz G, … Spurgin A
  • CONCLUSIONS: The findings suggest that impairing effects of this commonly prescribed combination of pharmacologic agents impact simulated driving performance. Negative changes in driving performance included measures of lateral and longitudinal control, although the deleterious effects on lateral control measures such as standard deviation of lane position (SDLP) were larger and more robust. Although the number of subjects was small, thus making it more difficult to draw conclusions on the narcotic effects, these results suggest that in this combination of central nervous system (CNS)-active drugs the benzodiazepine alprazolam accounted for the majority of impairing drug effects. The effect sizes associated with the hydrocodone preparation ranged from very small to medium. These results have potential implications for prescribing physicians and dispensing pharmacists, traffic safety experts, law enforcement officers, and patients themselves.
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