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7,455 results
  • Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia. [Journal Article]
    Int J Mol Sci. 2022 Dec 25; 24(1)Hu Y, Hill RA, Yoshimura M
  • To assess the role of adenylyl cyclase type 7 (AC7) in microglia's immune function, we generated AC7 gene knockout (AC7 KO) clones from a mouse microglial cell line, BV-2, using the CRISPR-Cas9 gene editing system. The ability of BV-2 cells to generate cAMP and their innate immune functions were examined in the presence or absence of ethanol. The parental BV-2 cells showed robust cAMP production …
  • A Review on Penile Doppler and Ultrasonography for Erectile Dysfunction. [Review]
    Curr Urol Rep. 2022 Nov 22 [Online ahead of print]Elgendi K, Zulia N, Beilan J
  • Herein, we seek to review the clinical applications of penile duplex Doppler ultrasound (PDDU) in sexual medicine practices and discuss the indications, protocols, advantages, and limitations of this diagnostic modality. Other more outdated diagnostic tests, such as cavernosometry, are briefly discussed to provide the reader a background of understanding on the evolution of diagnostic testing wit…
  • An Electrophysiological Technique to Accurately Diagnose and Treat Erectile Dysfunction. [Journal Article]
    J Vis Exp. 2022 Nov 04Liu K, Wang Z, … Gong Y
  • Erectile dysfunction (ED) is a common disease in males. In the past, the first-line treatment of ED was mainly noninvasive-psychotherapy and oral phosphodiesterase 5 (PDE5) inhibitors. Oral PDE5 inhibitors often need to be used before sexual intercourse and do not repair the pathological damage; hence, the therapeutic effect for secondary ED caused by neurological or endocrine disorders is poor. …
  • Apnea caused by retrobulbar anesthesia: A case report. [Case Reports]
    World J Clin Cases. 2022 Nov 06; 10(31):11646-11651.Wang YL, Lan GR, … Chen YX
  • CONCLUSIONS: Brainstem anesthesia is a serious complication secondary to retrobulbar anesthesia. Medical staff should pay attention to the identification of brainstem anesthesia and be familiar with the emergency treatment for this complication.
  • Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue. [Journal Article]
    Prostaglandins Other Lipid Mediat. 2023 Feb; 164:106682.Azırak S
  • Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-negative infections, especially in intensive care units. Despite its wide clinical indications, AK causes serious side effects such as kidney toxicity. AK was found to lead to tissue damage primarily through apoptosis and oxidative stress. Therefore, it was investigated whether misoprostol (MP), which has antiox…
  • High throughput screening of mesenchymal stem cell lines using deep learning. [Journal Article]
    Sci Rep. 2022 10 20; 12(1):17507.Kim G, Jeon JH, … Lee S
  • Mesenchymal stem cells (MSCs) are increasingly used as regenerative therapies for patients in the preclinical and clinical phases of various diseases. However, the main limitations of such therapies include functional heterogeneity and the lack of appropriate quality control (QC) methods for functional screening of MSC lines; thus, clinical outcomes are inconsistent. Recently, machine learning (M…
  • Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review. [Review]
    Sex Med Rev. 2022 10; 10(4):764-781.Hamzehnejadi M, Tavakoli MR, … Forootanfar H
  • CONCLUSIONS: Numerous formulations of PGE1 have been used to treat patients so far. Still, in general, with the evolution of classical formulation methods toward modern techniques (such as using nanocarriers and skin permeability enhancers), the probability of treatment success also increases. Hamzehnejadi M, Tavakoli MR, Homayoun F et al. Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review. Sex Med Rev 2022;10:764-781.
  • An original mininvasive corporoplasty technique for penile curvature without circumcision. [Journal Article]
    Arch Ital Urol Androl. 2022 Sep 26; 94(3):334-338.Rossi A, Alei G, … Calarco A
  • CONCLUSIONS: This is a simple and rapid technique that perfectly corrects even the most severe and complex penile curvatures. In comparison to traditional techniques, such as Nesbit procedure, this technique is associated with low morbidity, a very low recurrence rate and a great aesthetic results. Aesthetic and functional patients' satisfaction was excellent.
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