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481 results
  • Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions. [Review]
  • CDCochrane Database Syst Rev 2018 02 27; 2:CD011417
  • Akkinapally S, Hundalani SG, … Pammi M
  • CONCLUSIONS: There is insufficient evidence from randomized controlled trials to determine the safety and efficacy of PGE1 in neonates with ductal-dependent cardiac lesions. Evidence from observational trials have informed clinical practice on the use of PGE, which is now considered the standard of care for ductal-dependent cardiac lesions. It is unlikely that randomized controlled studies will be performed for this indication but comparative efficacy of newer formulations of PGE1, different doses of PGE1 and studies comparing PGE with PDA stents or other measures to keep the ductus open may be ethical and necessary.
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