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Unbound Medicine.
(alprostadil systemic )
522 results
  • Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review. [Review]
    Sex Med Rev. 2022 10; 10(4):764-781.Hamzehnejadi M, Tavakoli MR, … Forootanfar H
  • CONCLUSIONS: Numerous formulations of PGE1 have been used to treat patients so far. Still, in general, with the evolution of classical formulation methods toward modern techniques (such as using nanocarriers and skin permeability enhancers), the probability of treatment success also increases. Hamzehnejadi M, Tavakoli MR, Homayoun F et al. Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review. Sex Med Rev 2022;10:764-781.
  • An evaluation of anifrolumab for use in adults with systemic lupus erythematosus. [Review]
    Expert Rev Clin Immunol. 2022 11; 18(11):1095-1106.Ahmed AA, Osman N, Furie R
  • Type 1 interferons play a key role in the pathogenesis of systemic lupus erythematosus (SLE). An important clinical question is whether inhibiting the type 1 interferon pathway reduce the disease activity in SLE patients. This review evaluates the safety and efficacy of the monoclonal antibody against the type 1 interferon alpha receptor, anifrolumab, in patients with SLE.
  • Intermediate-term outcomes of deferred Norwood strategy. [Journal Article]
    Eur J Cardiothorac Surg. 2022 09 02; 62(4)Hoashi T, Imai K, … Ichikawa H
  • CONCLUSIONS: Although deferred Norwood provided acceptable intermediate-term survival, the Fontan completion rate was unsatisfactory. SAVV surgery and pulmonary artery intervention were frequently required.
  • Common pulmonary vein atresia. [Journal Article]
    Cardiol Young. 2022 Apr; 32(4):668-670.Glenn T, Honold J, … Mueller D
  • A 4-hour-old infant with profound cyanosis on an alprostadil infusion was urgently transferred to Rady Children's Hospital with suspected CHD. Upon arrival, urgent echocardiography was performed but could not confirm the presence of discrete pulmonary veins or pulmonary venous drainage. Given the difficulty in delineating the anatomy, a cardiac CT scan was performed and demonstrated a nearly atre…
  • Acute Limb Ischemia after Intake of the Phenylethylamine Derivate NBOMe. [Case Reports]
    Int J Environ Res Public Health. 2019 12 12; 16(24)Wadowski PP, Giurgea GA, … Koppensteiner R
  • Objective: N-(2-methoxy) benzyl-phenethylamine (NBOMe) derivatives have a high affinity to the serotonin receptor 2A and emerged as new psychedelic agents. We report the case of a 30-year-old man admitted to the hospital because of acute ischemia of the left arm with clinical symptoms of pallor, pulselessness, paresthesia, and a motoric deficit. The patient had a history of schizophrenia and drug…
  • Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions. [Review]
    Cochrane Database Syst Rev. 2018 02 27; 2:CD011417.Akkinapally S, Hundalani SG, … Pammi M
  • CONCLUSIONS: There is insufficient evidence from randomized controlled trials to determine the safety and efficacy of PGE1 in neonates with ductal-dependent cardiac lesions. Evidence from observational trials have informed clinical practice on the use of PGE, which is now considered the standard of care for ductal-dependent cardiac lesions. It is unlikely that randomized controlled studies will be performed for this indication but comparative efficacy of newer formulations of PGE1, different doses of PGE1 and studies comparing PGE with PDA stents or other measures to keep the ductus open may be ethical and necessary.
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