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33,756 results
  • Thrombolysis for Cardiogenic Shock Secondary to Aortic Bioprosthetic Valve-in-Valve Thrombosis. [Case Reports]
    Cureus. 2022 Dec; 14(12):e33141.Chu J, Nath N, Attanasio S
  • Valvular obstruction and thromboembolism are feared complications of bioprosthetic valve thrombosis. We describe the case of an 81-year-old man with a prior aortic valve-in-valve bioprosthesis who presented in cardiogenic shock, requiring mechanical circulatory support. He was found to have acute bioprosthetic valve thrombosis and was treated with systemic thrombolysis. This case highlights the o…
  • Interventions for acute non-arteritic central retinal artery occlusion. [Review]
    Cochrane Database Syst Rev. 2023 Jan 30; 1(1):CD001989.Lin JC, Song S, … Greenberg PB
  • Acute non-arteritic central retinal artery occlusion (CRAO) occurs as a sudden interruption of the blood supply to the retina and typically results in severe loss of vision in the affected eye. Although many therapeutic interventions have been proposed, there is no generally agreed upon treatment regimen.
  • Electrical Impedance Tomography As a Bedside Diagnostic Tool for Pulmonary Embolism. [Case Reports]
    Crit Care Explor. 2023 Jan; 5(1):e0843.Prins SA, Weller D, … den Uil CA
  • CONCLUSIONS: The hypertonic saline bolus EIT method as a diagnostic tool for pulmonary embolism is a promising new technique, which can be particularly meaningful for critically ill patients. Further study is required to evaluate the sensitivity and specificity of this technique and the impact on decision-making and outcomes of critically ill patients.
  • Albumin-based drug carrier targeting urokinase receptor for cancer therapy. [Journal Article]
    Int J Pharm. 2023 Jan 22 [Online ahead of print]Li H, Wang Z, … Huang M
  • Urokinase plasminogen activator receptor (uPAR) is a key participant in extracellular proteolysis, tissue remodeling and cell motility. uPAR overexpresses in most solid tumors and several hematologic malignancies, but has low levels on normal tissues, thus is advocated as a molecular target for cancer therapy. One of the obstacles for the evaluation of uPAR targeting agents in preclinical study i…
  • Advances in Antibody-Based Therapeutics for Cerebral Ischemia. [Review]
    Pharmaceutics. 2022 Dec 31; 15(1)Sun JM, Yen TL, … Yang CH
  • Cerebral ischemia is an acute disorder characterized by an abrupt reduction in blood flow that results in immediate deprivation of both glucose and oxygen. The main types of cerebral ischemia are ischemic and hemorrhagic stroke. When a stroke occurs, several signaling pathways are activated, comprising necrosis, apoptosis, and autophagy as well as glial activation and white matter injury, which l…
  • Urokinase System in Pathogenesis of Pulmonary Fibrosis: A Hidden Threat of COVID-19. [Journal Article]
    Int J Mol Sci. 2023 Jan 10; 24(2)Shmakova AA, Popov VS, … Semina EV
  • Pulmonary fibrosis is a common and threatening post-COVID-19 complication with poorly resolved molecular mechanisms and no established treatment. The plasminogen activator system, including urokinase (uPA) and urokinase receptor (uPAR), is involved in the pathogenesis of COVID-19 and contributes to the development of lung injury and post-COVID-19 pulmonary fibrosis, although their cellular and mo…
  • Osteopontin Is Associated with Multiple Sclerosis Relapses. [Journal Article]
    Biomedicines. 2023 Jan 11; 11(1)Stampanoni Bassi M, Buttari F, … Matarese G
  • CONCLUSIONS: Our results further suggest the role of osteopontin in acute MS relapses showing that, in proximity to relapses, osteopontin expression in CSF may be increased along with other proinflammatory mediators and correlated with decreased concentrations of anti-inflammatory molecules.
  • Functional Validation of the Putative Oncogenic Activity of PLAU. [Journal Article]
    Biomedicines. 2022 Dec 30; 11(1)Sarno F, Goubert D, … Rots MG
  • Plasminogen activator, urokinase (PLAU) is involved in cell migration, proliferation and tissue remodeling. PLAU upregulation is associated with an increase in aggressiveness, metastasis, and invasion of several cancer types, including breast cancer. In patients, this translates into decreased sensitivity to hormonal treatment, and poor prognosis. These clinical findings have led to the examinati…
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