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Unbound Medicine.
(altitude sickness)
4,631 results
  • Macitentan attenuates chronic mountain sickness in rats by regulating arginine and purine metabolism. [Journal Article]
    J Proteome Res. 2020 Jul 09 [Online ahead of print]Gao X, Zhang Z, … He K
  • Chronic mountain sickness (CMS) is a high-altitude complication with high rates of morbidity and mortality. CMS is characterized by high-altitude polycythemia (HAPC) and high-altitude pulmonary hypertension (HAPH). In this study, macitentan, a dual endothelin receptor antagonist, was used to treat CMS, and the induced metabolomics changes were studied. CMS was induced in rats in a hypobaric hypox…
  • Incidence and Determinants of Acute Mountain Sickness in Mount Kinabalu, Malaysia. [Journal Article]
    High Alt Med Biol. 2020 Jun 30 [Online ahead of print]Yang SL, Ibrahim NA, … Liew HB
  • Background: Acute mountain sickness (AMS) is the most common type of high-altitude sickness. The incidence of AMS varies by mountain location, trail characteristics, and study design. The lack of local epidemiology data has driven us to investigate the incidence and severity of AMS and its associated factors at Mount Kinabalu, Malaysia. …
  • [High altitude pulmonary edema misdiagnosed as pneumonia]. [Case Reports]
    Ter Arkh. 2019 Mar 15; 91(3):68-70.Sarybaev AS, Maripov AM, … Sydykov AS
  • High altitude pulmonary edema (HAPE) is a relatively rare form of high altitude illness. However, without immediate treatment, HAPE is fatal. Furthermore, HAPE is characterized by non-specific signs and symptoms, and many clinical conditions may mimic it. In the present article, we report a case of HAPE misdiagnosed as pneumonia. We also discuss the issues of prevention and early treatment option…
  • Ibuprofen versus acetazolamide for prevention of acute mountain sickness. [Journal Article]
    Medwave. 2020 Jun 11; 20(5):e7733.Schilling M, Irarrázaval S
  • CONCLUSIONS: We identified two systematic reviews that included only one primary study, which is a randomized trial. We concluded it is not possible to establish whether ibuprofen is better or worse than acetazolamide because the certainty of evidence has been evaluated as very low.
  • Incidence of decompression sickness in hypobaric hypoxia training. [Journal Article]
    Undersea Hyperb Med. 2020 Second Quarter; 47(2):203-210.Ercan E, Demir AE, … Toklu AS
  • Simulated flight in a hypobaric chamber is a fundamental component in the physiological training of aviators. Although rare, there is always a risk of decompression sickness (DCS) in trainees during hypobaric hypoxia training. In this study we aimed to determine the incidence of altitude-induced DCS and the symptoms manifested in trainees and inside chamber observers (ICOs) during the training se…
  • High-altitude mountain telemedicine. [Journal Article]
    J Telemed Telecare. 2020 Jun 15 [Online ahead of print]Martinelli M, Moroni D, … Pratali L
  • CONCLUSIONS: The e-Rés@MONT teleconsultation platform has been discussed in terms of treated cases, feasibility, proactivity in reducing complexities, direct and indirect advantages, and diagnostics help; moreover, general and specific pros and cons have been debated, and future steps have been exposed.
  • Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19? [Journal Article]
    Respir Physiol Neurobiol. 2020 Jun 06 [Online ahead of print]Soliz J, Schneider-Gasser EM, … Dutschmann M
  • A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level and higher might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. This epidemiological finding raises the question of whether physiological mechanisms underlying the acclimatization to high altitude identifies t…
  • StatPearls: Acute Mountain Sickness Score (LLS and AMS-C) [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Ahluwalia Amrit A University of Medicine and Health Sciences Underwood Philipp J. PJ North Shore University Hospital BOOK
  • Acute mountain sickness (AMS) is a syndrome that arises in non-acclimatized individuals who ascend to high altitudes. It is a form of acute altitude illness that occurs due to a decrease in the atmospheric partial pressure of oxygen as the altitude increases, inducing hypoxia. This condition typically occurs at an altitude of >2500 meters; however, it can occur at lower elevations in high-risk in…
  • EPAS1 regulates proliferation of erythroblasts in chronic mountain sickness. [Journal Article]
    Blood Cells Mol Dis. 2020 May 19; 84:102446.Liu H, Tang F, … Li Z
  • Excessive erythrocytosis (EE) is a characteristic of chronic mountain sickness (CMS). Currently, the pathogenesis of CMS remains unclear. This study was intended to investigate the role of EPAS1 in the proliferation of erythroblasts in CMS. Changes of HIF-1α and EPAS1/HIF-2α in the bone marrow erythroblasts of 21 patients with CMS and 14 control subjects residing at the same altitudes were determ…
  • Compound Danshen Dripping Pill Promotes Adaptation to Acute High-Altitude Exposure. [Journal Article]
    High Alt Med Biol. 2020 May 28 [Online ahead of print]Li Z, Guo J, … Chen Y
  • Background: In this study, we aimed to investigate whether the traditional Chinese medicine, Compound Danshen Dripping Pill (CDDP), can prevent acute mountain sickness (AMS). We allocated CDDP and matching placebos to 160 volunteers before they ascended to a high altitude. Treadmill exercise tests, echocardiography, blood routine examinations, biochemical analysis, and blood gas analysis were pe…
  • Blood viscosity and its determinants in the highest city in the world. [Journal Article]
    J Physiol. 2020 May 22 [Online ahead of print]Stauffer E, Loyrion E, … Verges S
  • CONCLUSIONS: Highlanders develop unique adaptative mechanisms to chronic hypoxic exposure, including substantial haemoglobin and haematocrit increases. However, a significant proportion of populations living permanently at high altitude develop maladaptive features known as chronic mountain sickness (CMS). This study aimed to assess the effects of permanent life at high altitude on clinical and haemorheological parameters (blood viscosity and red blood cell aggregation) and to compare clinical and haemorheological parameters of dwellers from the highest city in the world according to CMS severity. Blood viscosity increased with altitude, together with haemoglobin concentration and haematocrit. At 5100 m, highlanders with moderate-to-severe CMS had higher blood viscosity mainly at high shear rate and even at corrected haematocrit (40%), with a lower red blood cell aggregation. Blood viscosity may contribute to CMS symptomatology but the increased blood viscosity in CMS patients cannot solely be explained by the rise in haematocrit.
  • Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. [Journal Article]
    Front Physiol. 2020; 11:437.Heinrich EC, Orr JE, … Simonson TS
  • Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and excessive erythrocytosis, Hct varies markedly within Andean men and women and may be driven by individual differences in ventilatory control and/or sleep events which exac…
  • Effect of 8 days of exercise-heat acclimation on aerobic exercise performance of men in hypobaric hypoxia. [Journal Article]
    Am J Physiol Regul Integr Comp Physiol. 2020 May 20 [Online ahead of print]Salgado RM, Coffman KE, … Kenefick RW
  • Exercise-heat acclimation (EHA) induces adaptations that improves tolerance to heat exposure. Whether adaptations from EHA can also alter responses to hypobaric hypoxia (HH) conditions remains unclear. This study assessed whether EHA can alter time-trial performance and/or incidence of acute mountain sickness (AMS) during HH exposure. Thirteen sea level (SL) resident men (SL VO2peak: 3.19 ± 0.43 …
  • Health risk of travel for chronic kidney disease patients. [Review]
    J Res Med Sci. 2020; 25:22.Furuto Y, Kawamura M, … Shibuya Y
  • The number of people with chronic kidney disease (CKD) has increased and so has their demand for travel. However, the health risk posed by travel in these patients is unclear. Few reports document the travel risk in CKD and dialysis patients. The aim of this study is to summarize the existing evidence of the influence of travel on risks in CKD patients. We aim to describe the association between …
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