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467 results
  • Room-Temperature Dialkylamination of Chloroheteroarenes Using a Cu(II)/PTABS Catalytic System. [Journal Article]
    Chem Asian J. 2023 Jan 03; 18(1):e202201006.Shet H, Patel M, … Kapdi AR
  • The dimethylamino functionality has significant importance in industrially relevant molecules and methodologies to install these efficiently are highly desirable. We report herein a highly efficient, room-temperature dimethylamination of chloroheteroarenes performed via the in-situ generation of dimethylamine using N,N-dimethylformamide (DMF) as precursor wiith a large substrate scope that includ…
  • Mode of interaction of altretamine with calf thymus DNA: biophysical insights. [Journal Article]
    J Biomol Struct Dyn. 2022 Mar 28 [Online ahead of print]Goswami S, Ghosh R, … Kishore N
  • Insights into drug-DNA interactions have importance in medicinal chemistry as it has a major role in the evolution of new therapeutic drugs. Therefore, binding studies of small molecules with DNA are of significant interest. Spectroscopy, coupled with measurements of viscosity and molecular docking studies were employed to obtain mechanistic insights into the binding of altretamine with calf thym…
  • The mechanisms and therapeutic targets of ferroptosis in cancer. [Journal Article]
    Expert Opin Ther Targets. 2021 11; 25(11):965-986.Ye L, Jin F, … Dai Y
  • Ferroptosis, a form of programmed cell death, is mediated primarily by lipid peroxidation via a unique iron-dependent process. The mechanisms of ferroptosis involve the metabolisms of amino acids, irons, and lipids, and the regulation of antioxidant systems. Evidence supports the roles of ferroptosis in cancer, while metabolic reprogramming (a hallmark of cancer) renders tumor cells highly vulner…
  • Metabonomics analysis of Zi goose follicular granulosa cells using ENO1 gene expression interference. [Journal Article]
    J Anim Physiol Anim Nutr (Berl). 2020 May; 104(3):838-846.Ji H, Guo W, … Wang J
  • The Zi goose is native to North-east China and is noted for its high egg production. Alpha enolase (ENO1) is a glycolytic enzyme which functions as a plasminogen receptor in follicular granulosa cells (FGCs), with several studies showing that FGCs can support follicular development. By transfecting the ENO1 interfering plasmid (shRNA) into FGCs, ENO1 expression in these cells was downregulated, s…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Altretamine [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Altretamine is an orally administered alkylating agent, formerly known as hexamethylmelamine, which is currently used as a secondary therapy for advanced ovarian carcinoma. Altretamine therapy has been associated with low rates of serum enzyme elevations during therapy and with rare instances of acute, clinically apparent injury.
  • Elucidating Compound Mechanism of Action by Network Perturbation Analysis. [Journal Article]
    Cell. 2015 Jul 16; 162(2):441-451.Woo JH, Shimoni Y, … Califano A
  • Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds characterizing their targets, effectors, and activity modulators represents a highly relevant yet elusive goal, with critical implications for assessment of compound efficacy and toxicity. Current approaches are labor intensive and mostly limited to elucidating high-affinity binding target proteins. We introdu…
  • Topotecan: weighing in when there are many options. [Comment]
    Oncologist. 2005 Oct; 10(9):698-700.Penson RT, Seiden MV
  • The manuscript by Armstrong et al. in this issue of The Oncologist, reviewing the toxicity and efficacy of full-dose topotecan delivered as second-line therapy in individuals with small cell lung cancer or ovarian cancer, will likely serve as both the most comprehensive and the final review of this active agent delivered at the U.S. Food and Drug Administration-approved dosage and schedule. The r…
  • Recurrent ovarian cancer: how important is it to treat to disease progression? [Review]
    Clin Cancer Res. 2004 Nov 15; 10(22):7439-49.Herzog TJ
  • Ovarian cancer is increasingly recognized as a chronic disease whose treatment is often characterized by administration of multiple, sequential active agents, each of which may or may not be accompanied by a tumor response. Despite the large proportion of patients who relapse and undergo longer-term treatment, the question of optimal treatment duration has not been fully addressed to date. For pa…
  • Part II: chemotherapy for epithelial ovarian cancer-treatment of recurrent disease. [Review]
    Lancet Oncol. 2002 Sep; 3(9):537-45.Harries M, Gore M
  • For women with advanced ovarian cancer, rates of response to first-line chemotherapy are high but most patients have relapses and become candidates for further chemotherapy. Chemotherapy for recurrence can palliate symptoms, and there is some evidence that it can also improve survival in this clinical situation. Patients who relapse quickly after first-line therapy should not be given the same dr…
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