- Molecular dynamics investigation of the asphaltene-kaolinite interactions in water, toluene, and water-toluene mixtures. [Journal Article]Phys Chem Chem Phys. 2023 Feb 02 [Online ahead of print]PC
- Understanding the interactions of petroleum asphaltenes with mineral surfaces is important for diluted bitumen spill response and modeling. In this study, molecular dynamics and umbrella sampling simulations are performed using interfacially active and non-interfacially active asphaltene model compounds individually positioned near each of the surfaces of kaolinite in the presence of explicit sol…
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- Expression of FMD virus-like particles in yeast Hansenula polymorpha and immunogenicity of combine with CpG and aluminum adjuvant. [Journal Article]J Vet Sci. 2023 Jan; 24(1):e15.JV
- CONCLUSIONS: The expression of VLPs of FMD in H. polymorpha provides a novel strategy for the generation of the FMDV vaccine.
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- Recombinant full-length Bacillus Anthracis protective antigen and its 63 kDa form elicits protective response in formulation with addavax. [Journal Article]
- Bacillus anthracis is the causative agent for the lethal disease anthrax, primarily affecting animals and humans in close contact with an infected host. The pathogenicity of B. anthracis is attributed to the secreted exotoxins and their outer capsule. The host cell-binding exotoxin component "protective antigen" (PA) is reported to be a potent vaccine candidate. The aim of our study is to produce…
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- Study on adsorption and recovery utilization of phosphorus using alkali melting-hydrothermal treated oil-based drilling cutting ash. [Journal Article]J Environ Manage. 2023 Jan 26; 332:117373.JE
- Oil-based drill cutting ash (OBDCA) was treated by alkali melting-hydrothermal method and used as novel adsorbent (AM-HT-OBDCA) for the recovery of phosphorus (P) in water body. The experiment parameter for preparation of AM-HT-OBDCA was optimized, including alkali melting ratio (MOBDCA: MNaOH), alkali melting temperature and hydrothermal temperature. The adsorption process of phosphorus on AM-HT…
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- Effect of calcitriol treated mesenchymal stem cells as an immunomodulation micro-environment on allergic asthma in a mouse model. [Journal Article]Endocr Metab Immune Disord Drug Targets. 2023 Jan 27 [Online ahead of print]EM
- CONCLUSIONS: Using the allergic asthma model, we were able to show that calcitriol-treated MSCs had an inhibitory impact on airway inflammation. Our findings suggest that the injection of calcitriol-treated MSCs may be a viable treatment option for allergic asthma.
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- Cationic liposomes bearing Bet v 1 by coiled coil-formation are hypo-allergenic and induce strong immunogenicity in mice. [Journal Article]
- Although aluminum hydroxide (alum) is widely accepted and used as safe vaccine adjuvant, there is some concern about possible toxicity upon long-lasting repeated exposure during subcutaneous allergen immunotherapy (SCIT). Our objective was to evaluate allergen-bearing liposomes as possible alternative for alum-adsorption in SCIT. A self-assembling, coiled-coil forming peptide pair was used to anc…
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- Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy. [Journal Article]J Control Release. 2023 Jan 27; 354:770-783.JC
- The poor cancer immunotherapy outcome has been closely related to immunosuppressive tumor microenvironment (TME), which usually inactivates the antitumor immune cells and leads to immune tolerance. Metalloimmunotherapy by supplementing nutritional metal ions into TME has emerged as a potential strategy to activate the tumor-resident immune cells. Herein, we engineered a magnesium-contained nano-a…
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- Maternal Lactobacillus rhamnosus administration impacts neonatal CD4 T-cell activation and prevents murine T helper 2-type allergic airways disease. [Journal Article]
- Gut microbiota plays a role in the neonatal immune education and could influence susceptibility to Th2-type immune disorders, such as allergies, the most prevalent chronic diseases in early childhood. We studied the impact of oral Lactobacillus rhamnosus (L.rhamnosus) supplementation to pregnant/breastfeeding C57BL/6 mice on the development of allergic airways disease in their offspring. We obser…
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- Maturation of Aluminium Adsorbed Antigens Contributes to the Creation of Homogeneous Vaccine Formulations. [Journal Article]
- Although aluminium-based vaccines have been used for almost over a century, their mechanism of action remains unclear. It is established that antigen adsorption to the adjuvant facilitates delivery of the antigen to immune cells at the injection site. To further increase our understanding of aluminium-based vaccines, it is important to gain additional insights on the interactions between the alum…
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- A Retrospective Study of the Safety and Immunogenicity of MVC-COV1901 Vaccine for People Living with HIV. [Journal Article]
- CONCLUSIONS: Further investigations may be needed to determine whether PWH require distinct immunization strategies with improved immunogenicity. The main study is registered at ClinicalTrials.gov (NCT04695652).
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- Vertical Etching of Scandium Aluminum Nitride Thin Films Using TMAH Solution. [Journal Article]
- A wide bandgap, an enhanced piezoelectric coefficient, and low dielectric permittivity are some of the outstanding properties that have made ScxAl1-xN a promising material in numerous MEMS and optoelectronics applications. One of the substantial challenges of fabricating ScxAl1-xN devices is its difficulty in etching, specifically with higher scandium concentration. In this work, we have develope…
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- Effect of Autoclaving on the Physicochemical Properties and Biological Activity of Aluminum Oxyhydroxide Used as an Adjuvant in Vaccines. [Journal Article]
- The long-term biodistribution of non-biodegradable microstructures or nanostructures used in vaccinations is widely unknown. This is the case for aluminum oxyhydroxide, the most widely used vaccine adjuvant, which is a nanocrystalline compound that spontaneously forms nanoprecipitates. Although generally well-tolerated, aluminum oxyhydroxide is detected in macrophages a long time after vaccinatio…
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- Duplex Coating Combing Vanadate-Intercalated Layered Double Hydroxide and Ce-Doped Sol-Gel Layers on Aluminum Alloy for Active Corrosion Protection. [Journal Article]
- In this study, a duplex coating system (LDH-V/SG-Ce) of vanadate-intercalated layered double hydroxide (LDH) and Ce-doped sol-gel (SG) layers was developed for the purpose of active corrosion protection of the aluminum alloy AA2024. ZnAl-LDH film was grown in situ on the surface of an aluminum alloy using a hydrothermal method and intercalated with V2O74- anions as corrosion inhibitors, and seale…
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- Preparation of CaCO3/Al(OH)3 Composites via Heterogeneous Nucleation. [Journal Article]
- As one of the most widely used inorganic fine powder fillers, calcium carbonate is cheap. However, considering its poor light transmittance, it is not suitable to be added to resin matrix composites that require high light transmittance. Aluminum hydroxide has good light transmission and flame retardancy, but it is more expensive than calcium carbonate. CaCO3/Al(OH)3 composites with a core-shell …
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- The trehalose glycolipid C18Brar promotes antibody and T-cell immune responses to Mannheimia haemolytica and Mycoplasma ovipneumoniae whole cell antigens in sheep. [Journal Article]
- Bronchopneumonia is a common respiratory disease in livestock. Mannheimia haemolytica is considered the main causative pathogen leading to lung damage in sheep, with Mycoplasma ovipneumoniae and ParaInfluenza virus type 3, combined with adverse physical and physiological stress, being predisposing factors. A balance of humoral and cellular immunity is thought to be important for protection agains…
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- Modified Dingchuan Decoction treats cough-variant asthma by suppressing lung inflammation and regulating the lung microbiota. [Journal Article]J Ethnopharmacol. 2023 Jan 13; 306:116171.JE
- CONCLUSIONS: This study demonstrated that treating CVA with MDD may be related to inhibiting lung inflammation and regulating lung microbiota.
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- Fabrication of γ-Al2O3 Nanoarrays on Aluminum Foam Assisted by Hydroxide for Monolith Catalysts. [Journal Article]
- Heat distribution and good adhesion of the washcoat on monolith catalysts are critical to improving catalytic activity and long-term stability. Compared with cordierite, metal foam presents a high thermal conductivity coefficient. Also, the availability of "washcoat" in situ grown on metal substrates opens the door to eliminating the problem of coating peeling. Generally, hydrothermal or thermal …
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- Strategical development of chrome-free tanning agent by integrating layered double hydroxide with starch derivatives. [Journal Article]Carbohydr Polym. 2023 Mar 15; 304:120511.CP
- The development of sustainable and eco-friendly leather industry requires green tanning agents because of unbounded chromium (easily converted into hazardous Cr-VI) in chrome tanned leather. In this study, a chrome-free tanning agent (OS-LDHs) was established by integrating layered double hydroxide (magnesium aluminum zirconium hydrotalcite, LDHs) with starch derivatives. A series of oxidized sta…
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- Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain. [Journal Article]Brain Res. 2023 Jan 10; 1803:148241.BR
- The current study was designed to assess the possible neuroprotective effect of borax (BX) against the toxicity of aluminum hydroxide [AH, Al (OH)3] on brain of rainbow trout (Oncorhynchus mykiss) with multibiomarker approaches. For this purpose, the presence of the neuroprotective action by BX against the AH exposure was assessed by the activities of catalase (CAT), glutathione peroxidase (GPx),…
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- Comparison of Immunogenicity Between a Candidate Live Attenuated Vaccine and an Inactivated Vaccine for Cache Valley Virus. [Journal Article]
- Cache Valley virus (CVV) is a mosquito-borne bunyavirus that is enzootic throughout the new world. Although CVV is known as an important agricultural pathogen, primarily associated with embryonic lethality and abortions in ruminants, it has recently been recognized for its expansion as a zoonotic pathogen. With the increased emergence of bunyaviruses with human and veterinary importance, there ha…
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- [Prediction of Pathogenesis and Potential Therapeutic Targets for Asthma Based on Proteomics of Mouse Lung Tissue]. [Journal Article]Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Dec; 44(6):961-969.ZY
- Objective To predict the mechanism and potential therapeutic targets of asthma based on proteomic analysis and network pharmacology.Methods The mouse model of asthma was established via intraperitoneal injection of 200 μl suspension containing 100 μg ovalbumin(OVA)and 2 mg aluminum hydroxide and intranasal administration with 5% OVA.Maxquant system was used to retrieve the protein and gene data.T…
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- New Polymer Composites with Aluminum Phosphates as Hybrid Flame Retardants. [Journal Article]
- Polymeric aluminum organophosphates are a class of nanostructured aluminum-based compounds that can be considered organic and inorganic hybrid materials. Aluminum phosphates have attracted considerable interest due to their ability to enhance composite materials' mechanical characteristics, lightweight, and thermal properties. Extensive studies have shown the potential of aluminum organophosphate…
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- Enhanced Bactericidal Effect of Calcinated Mg-Fe Layered Double Hydroxide Films Driven by the Fenton Reaction. [Journal Article]
- Osteogenic and antibacterial abilities are the permanent pursuit of titanium (Ti)-based orthopedic implants. However, it is difficult to strike the right balance between these two properties. It has been proved that an appropriate alkaline microenvironment formed by Ti modified by magnesium-aluminum layered double hydroxides (Mg-Al LDHs) could achieve the selective killing of bacteria and promote…
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- Introducing Porosity into Refractory Molybdenum Boride through Controlled Decomposition of a Metastable Mo-Al-B Precursor. [Journal Article]J Am Chem Soc. 2023 Jan 18; 145(2):1423-1432.JA
- The high temperatures typically required to synthesize refractory compounds preclude the formation of high-energy morphological features, including nanoscopic pores that are beneficial for applications, such as catalysis, that require higher surface areas. Here, we demonstrate a low-temperature multistep pathway to engineer mesoporosity into a catalytic refractory material. Mesoporous molybdenum …
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- Critical evaluation on roles of macrophagic myofasciitis and aluminum adjuvants in HPV vaccine-induced adverse events. [Review]Cancer Sci. 2023 Jan 05 [Online ahead of print]CS
- Cervical cancer is caused by human papillomavirus (HPV) infection, which is preventable by HPV vaccines. In Japan, the HPV vaccination rate has remained extremely low due to the concerns for alleged neuropsychological symptoms or "diverse symptoms" following injections of two HPV vaccines, Cervarix and Gardasil, in HPV vaccine lawsuits. In the lawsuits, the attorneys' group has used several manus…
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- A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. [Preprint]bioRxiv. 2022 Dec 26B
- While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), el…
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- Impact of iron/aluminum (hydr)oxide and clay minerals on heteroaggregation and transport of nanoplastics in aquatic environment. [Journal Article]J Hazard Mater. 2023 Mar 15; 446:130649.JH
- Nanoplastics (NPs) are emerging contaminants in the environment, where the transport and fate of NPs would be greatly affected by interactions between NPs and minerals. In the present study, the interactions of two types of polystyrene nanoplastics (PSNPs), i.e., bare-PSNPs and carboxylated PSNPs-COOH, with iron (hydr)oxides (hematite, goethite, magnetite, and ferrihydrite), aluminum (hydr)oxides…
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- β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis. [Journal Article]J Ethnopharmacol. 2022 Dec 28 [Online ahead of print]JE
- CONCLUSIONS: The results of this study shows that β-HB can reduce inflammation and oxidative stress, the increased production of β-HB in serum might be the crucial factor for Suhuang to exert its effect in the treatment of CVA.
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- Comparative efficacy of medicaments or techniques for pulpotomy of primary molars: a network meta-analysis. [Review]
- CONCLUSIONS: Our results suggested that MTA was associated with significant improvement in both clinical and radiographic success than other pulpotomy medicaments and techniques, with the highest probability of being the optimal option.
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- Enhanced coagulation process for removing dissolved organic matter, microplastics, and silver nanoparticles. [Journal Article]J Environ Sci Health A Tox Hazard Subst Environ Eng. 2022; 57(13-14):1084-1098.JE
- Dissolved organic carbon (DOC), microplastics (MPs), and silver nanoparticles (AgNPs) in water are of major concern because of their direct and indirect toxic effects on aquatic organisms and human exposure via water. This work investigated the effect of poly aluminum chloride (PACl) coagulation for reducing DOC, MPs, and AgNPs. This work used water from a canal in Thailand with a DOC of 5.2 mg/L…
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