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8,027 results
  • Influenza Treatment: Limitations of Antiviral Therapy and Advantages of Drug Combination Therapy. [Review]
    Microorganisms. 2023 Jan 11; 11(1)Batool S, Chokkakula S, Song MS
  • Influenza infection is serious and debilitating for humans and animals. The influenza virus undergoes incessant mutation, segment recombination, and genome reassortment. As a result, new epidemics and pandemics are expected to emerge, making the elimination challenging of the disease. Antiviral therapy has been used for the treatment of influenza since the development of amantadine in the 1960s; …
  • Dopamine Agonist Cotreatment Alters Neuroplasticity and Pharmacology of Levodopa-Induced Dyskinesia. [Journal Article]
    Mov Disord. 2023 Jan 19 [Online ahead of print]Espa E, Song L, … Cenci MA
  • CONCLUSIONS: Cotreatment with ropinirole altered LID-related neuroplasticity and pharmacological response profiles. The impact of adjuvant dopamine agonist treatment should be taken into consideration when investigating LID mechanisms and candidate interventions in both clinical and experimental settings. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
  • Off-time Treatment Options for Parkinson's Disease. [Review]
    Neurol Ther. 2023 Jan 12 [Online ahead of print]Fabbri M, Barbosa R, Rascol O
  • Motor fluctuations (MF) are deemed by patients with Parkinson's disease (PD) as the most troublesome disease feature resulting from the increasing impairment in responsiveness to dopaminergic drug treatments. MF are characterized by the loss of a stable response to levodopa over the nychthemeron with the reappearance of motor (and non-motor) parkinsonian clinical signs at various moments during t…
  • The Rossy Progressive Supranuclear Palsy Centre: Creation and Initial Experience. [Journal Article]
    Can J Neurol Sci. 2023 Jan 05 [Online ahead of print]Couto B, Fox S, … Lang AE
  • CONCLUSIONS: The Rossy PSP Centre has been established to advance clinical and basic research in PSP and related tauopathies. The extent of the clinical data collected permits deep phenotyping of patients and allows for future clinical and basic research. Preliminary results showed expected distribution of phenotypes, demographics, and response to symptomatic treatments in our cohort. Longitudinal data will provide insight into the early diagnosis and management of PSP. Future steps include enrollment of patients in earlier stages, development of biomarkers, and fast-tracking well-characterized patients into clinical trials.
  • The Differential Diagnosis and Treatment of Mild Cognitive Impairment and Alzheimer Disease. [Journal Article]
    J Clin Psychiatry. 2022 Dec 26; 84(1)Anderson A, Malone M
  • Identifying patients at risk for developing mild cognitive impairment (MCI) and Alzheimer disease (AD) remains challenging in clinical practice, even as scientific understanding of dementia advances generally. That said, successfully navigating the associated differential diagnosis in AD is essential, as various causes of cognitive impairment require different treatment strategies. In recent year…
  • Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review. [Review]
    Life (Basel). 2022 Dec 19; 12(12)Buzzi M, Giannaccare G, … Mencucci R
  • Parkinson disease (PD) is a progressive, neurodegenerative disease of the central nervous system. Visual disturbance is one of the most frequent nonmotor abnormalities referred to by patients suffering from PD at early stages. Furthermore, ocular surface alterations including mainly dry eye and blink reduction represent another common finding in patients with PD. Tears of PD patients show specifi…
  • Neurotensin-Binding Immunoglobulin G in Patients with Parkinson's Disease. [Journal Article]
    Neuroimmunomodulation. 2022 Dec 14 [Online ahead of print]Muruzheva ZM, Egorov DS, … Fetissov SO
  • CONCLUSIONS: The study revealed that NTS-binding IgG occur naturally in humans and that PD patients display their low plasma levels accentuated by disease severity. The functional significance of this finding and its relevance to the pathophysiology of PD, including putative link to gut microbiota, remain to be studied.
  • Uptake and Transport of Different Concentrations of PPCPs by Vegetables. [Journal Article]
    Int J Environ Res Public Health. 2022 11 28; 19(23)Zeng Y, Zhang Y, … Ai L
  • In many parts of the world, water resources are scarce or even extremely scarce, and the reuse of water resources has become mainstream in today's world. Many regions use treated wastewater for agricultural irrigation, aquaculture, and other activities. However, in recent years, wastewater has been found to contain large amounts of pharmaceuticals and personal care products (PPCPs). Therefore, th…
  • Levodopa-Induced Dyskinesia in Parkinson's Disease: Pathogenesis and Emerging Treatment Strategies. [Review]
    Cells. 2022 Nov 23; 11(23)Kwon DK, Kwatra M, … Ko HS
  • The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement therapy using levodopa during the course of the disease's progression. However, despite the fact that levodopa is the "gold standard" in PD treatments and has the ability to significantly alleviate PD symptoms, it comes wi…
  • Dyskinesia and Parkinson's disease: animal model, drug targets, and agents in preclinical testing. [Review]
    Expert Opin Ther Targets. 2022 10; 26(10):837-851.Cesaroni V, Blandini F, Cerri S
  • Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. PD patients exhibit a classic spectrum of motor symptoms, arising when dopamine neurons in the substantia nigra pars compacta are reduced by 60%. The dopamine precursor L-DOPA represents the most effective therapy for improving PD motor dysfunctions, thus far available. Unfortunately, long-term…
  • Ropinirole involved in a fatal case: blood and urinary concentrations. [Journal Article]
    Forensic Toxicol. 2022 01; 40(1):173-179.Nagasawa S, Yamaguchi R, … Iwase H
  • CONCLUSIONS: There were no obvious signs of overdose, and the high cardiac/peripheral blood ratio suggested that postmortem redistribution may have occurred, but the peripheral blood ropinirole concentration (100 ng/mL) was obviously higher than that reported in the previous fatal case of ropinirole poisoning (64 ng/mL). Based on these results, the cause of death in this case was considered to be shock and fatal arrhythmia due to ropinirole poisoning. This case provides important data on postmortem blood and urinary levels of ropinirole poisoning.
  • Multidisciplinary Management of Brain Metastasis from Breast Cancer. [Review]
    Hematol Oncol Clin North Am. 2023 Feb; 37(1):183-202.Trapani D, Aizer AA, Lin NU
  • The management of patients with breast cancer and brain metastases (BMs) is exquisitely multidisciplinary. Patients presenting with a symptomatic BM may be offered neurosurgical resection, followed by radiation. Stereotactic radiosurgery (SRS) is preferred over whole-brain radiotherapy (WBRT) in most patients presenting with a limited number of BMs, whereas WBRT with hippocampal-sparing and conco…
  • Essential Oils and Their Compounds as Potential Anti-Influenza Agents. [Review]
    Molecules. 2022 Nov 12; 27(22)Oriola AO, Oyedeji AO
  • Essential oils (EOs) are chemical substances, mostly produced by aromatic plants in response to stress, that have a history of medicinal use for many diseases. In the last few decades, EOs have continued to gain more attention because of their proven therapeutic applications against the flu and other infectious diseases. Influenza (flu) is an infectious zoonotic disease that affects the lungs and…
  • Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates. [Review]
    Int J Mol Sci. 2022 Nov 17; 23(22)Finsterer J
  • Guillain-Barré syndrome (GBS) is a rare immune-mediated acute polyradiculo-neuropathy that typically develops after a previous gastrointestinal or respiratory infection. This narrative overview aims to summarise and discuss current knowledge and previous evidence regarding triggers and pathophysiology of GBS. A systematic search of the literature was carried out using suitable search terms. The m…
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