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7,186 results
  • [Parkinson's Disease: amantadine, zonisamide, dabrafenib]. [Journal Article]
    Brain Nerve 2019; 71(9):953-959Okamoto T
  • Among the therapeutic agents for Parkinson's disease (PD), there are important drugs that precede drug repositioning. Amantadine, developed as a treatment for influenza A, has been long used as a treatment for PD. Zonisamide is an antiepileptic drug developed in Japan, where its therapeutic effects on PD were also discovered and developed. In recent years, dabrafenib, a therapeutic agent for mali…
  • Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. [Journal Article]
    Brain 2019; 142(7):1887-1893Fridman EA, Osborne JR, … Schiff ND
  • Dopaminergic stimulation has been proposed as a treatment strategy for post-traumatic brain injured patients in minimally conscious state based on a clinical trial using amantadine, a weak dopamine transporter blocker. However, a specific contribution of dopaminergic neuromodulation in minimally conscious state is undemonstrated. In a phase 0 clinical trial, we evaluated 13 normal volunteers and …
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