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6,953 results
  • Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors. [Journal Article]
  • PlosPLoS One 2018; 13(9):e0203148
  • Mathew S, Al Thani AA, Yassine HM
  • CONCLUSIONS: Using in silico docking analysis, we identified 18 bioactive flavonoids with potential strong binding cababilities to influenza HA-stems of various subtypes, which are the target for bNAb. The virtual screened bioassay hit compounds depicted a high number of Hbonds but low interaction and docking values compared to antiviral flavonoids. Using structure-based design and nanotechnology-based approaches, identified molecules could be modified to generate next generation anti-influenza drugs.
  • Clinical and genetic investigation of amantadine-associated corneal edema. [Journal Article]
  • COClin Ophthalmol 2018; 12:1367-1371
  • Hessen MM, Vahedi S, … Eghrari AO
  • CONCLUSIONS: Amantadine-associated corneal edema is characteristically posterior and central and appears unlikely to represent early or subclinical decompensation of Fuchs dystrophy. We describe the unique outcome of continued corneal clearance after restarting amantadine concurrently with steroids, a pattern that has persisted over 32 months to date.
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