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382 results
  • Combination therapy improves vascular volume in female rats with pulmonary hypertension. [Journal Article]
    Am J Physiol Lung Cell Mol Physiol 2019; 317(4):L445-L455Lachant DJ, Meoli DF, … White RJ
  • Pulmonary arterial hypertension (PAH) is a female predominant disease in which progressive vascular remodeling and vasoconstriction result in right ventricular (RV) failure and death. Most PAH patients utilize multiple therapies. In contrast, the majority of preclinical therapeutic studies are performed in male rats with a single novel drug often markedly reversing disease in the model. We sought…
  • Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. [Journal Article]
    Sci Rep 2019; 9(1):9089Todorović V, Su Z, … Scott VE
  • IL-36 cytokines are pro-inflammatory members of the IL-1 family that are upregulated in inflammatory disorders. Specifically, IL-36γ is highly expressed in active psoriatic lesions and can drive pro-inflammatory processes in 3D human skin equivalents supporting a role for this target in skin inflammation. Small molecule antagonists of interleukins have been historically challenging to generate. N…
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