- An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis. [Journal Article]Drug Deliv. 2023 Dec; 30(1):2173332.DD
- Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function. The therapeutic efficacy of RA treatments with the severely affected side remains unsatisfactory despite current treatment methods that primarily focus on anti-inflammatory activity, largely because of the complicatedly pathologica…
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- Starvation-assisted and photothermal-thriving combined chemo/chemodynamic cancer therapy with PT/MR bimodal imaging. [Journal Article]Biomater Sci. 2023 Feb 01 [Online ahead of print]BS
- Chemodynamic therapy (CDT) reflects a novel reactive oxygen species (ROS)-related cancer therapeutic approach. However, CDT monotherapy is often limited by weak efficacy and insufficient endogenous H2O2. Herein, a multifunctional combined bioreactor (MnFe-LDH/MTX@GOx@Ta, MMGT) relying on MnFe-layered double hydroxide (MnFe-LDH) loaded with methotrexate (MTX) and coated with glucose oxidase (GOx)/…
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- An Unusual Presentation of a Patient With Low-Dose Methotrexate Causing Colitis and Pancytopenia. [Case Reports]Cureus. 2022 Dec; 14(12):e33062.C
- This paper summarizes the case of a patient admitted to the hospital due to methotrexate-induced colitis in the setting of pancytopenia. Although methotrexate is commonly used for a variety of diseases, this medication can precipitate side effects in a subset of patients. This is an atypical case of chronic low-dose methotrexate use leading to colitis and pancytopenia. It is of utmost significanc…
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- Differences in prescriptions for systemic medications and nonsteroidal topicals among children with atopic dermatitis. [Journal Article]Pediatr Dermatol. 2023 Jan 31 [Online ahead of print]PD
- Nonsteroidal topicals and systemic therapies are often utilized for atopic dermatitis (AD) in children with inadequate response to topical corticosteroids. We sought to characterize patient factors associated with prescriptions for nonsteroidal topical (tacrolimus, pimecrolimus, crisaborole), systemic immunosuppressant (methotrexate, mycophenolate, cyclosporine, azathioprine), and systemic cortic…
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- Diagnosis, treatment, and prognosis of primary intraocular lymphoma: Single-center real-world clinical experience. [Journal Article]Cancer Med. 2023 Jan 31 [Online ahead of print]CM
- CONCLUSIONS: For PIOL, aggressive systemic treatment equivalent to that of primary CNS lymphoma (PCNSL) is recommended because solely HD-MTX did not prevent or delay CNS relapse. To prevent PIOL relapse in the CNS efficiently, prospective trials with large numbers of patients and advanced therapeutic regimens are necessary. Furthermore, regular clinical follow-up is crucial, and the IL-10/IL-6 ratio can help evaluate relapse promptly.
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- Four-year follow-up of surface contamination by antineoplastic drugs in a compounding unit. [Journal Article]Occup Environ Med. 2023 Jan 30 [Online ahead of print]OE
- CONCLUSIONS: From the beginning of the study and from month to month, surface contamination was limited to the nearest sampling points to the compounding unit. This 4-year monitoring study allowed us to determine the intravenous conventional antineoplastic drugs and sampling points to be focused on.
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- [[Translated article]]Intralesional Methotrexate for Keratoacanthomas: A Case Series. [Case Reports]Actas Dermosifiliogr. 2023 Jan 27 [Online ahead of print]AD
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- Identification of cell-specific differential DNA methylation associated with methotrexate treatment response in rheumatoid arthritis. [Journal Article]Arthritis Rheumatol. 2023 Jan 30 [Online ahead of print]AR
- CONCLUSIONS: We identified cell-specific changes in DNAm associated with MTX response in RA patients. Future studies of DNAm and MTX response should include measurements of DNAm from sorted cells.
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- Identification of hub genes involved in cisplatin resistance in head and neck cancer. [Journal Article]J Genet Eng Biotechnol. 2023 Jan 30; 21(1):9.JG
- CONCLUSIONS: As the pathogenesis of head and neck cancer is complex, targeting hub genes and associated pathways involved in cisplatin resistance could bring a milestone change in the drug discovery and management of drug resistance which might uplift overall survival among HNC patients.
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- Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups. [Journal Article]Neuro Oncol. 2023 Jan 30 [Online ahead of print]NO
- CONCLUSIONS: These data suggest further heterogeneity within early childhood SHH-DMB/MBEN: SHH-2 splits into a very low-risk group SHH-2a enriched for MBEN histology and SMO mutations, and SHH-2b comprising older DMB patients with higher risk of relapse.
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- A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells. [Journal Article]
- Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. This study investigated relationships between accumulation of methotrexate and gene expression levels of solute …
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- Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma. [Case Reports]
- Primary cranial vault lymphoma (PCVL) is a rare lymphoma involving the skull with or without extra- and intracranial extension. Most cases of PCVL are diffuse large B-cell lymphoma (DLBCL). We report a case of primary cranial vault diffuse large B-cell lymphoma (PCV-DLBCL) that was successfully treated with anthracycline-based chemoimmunotherapy (CIT) alternating with central nervous system (CNS)…
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- Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]Farm Hosp. 2023 Jan 27 [Online ahead of print]FH
- CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
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- Rectal Ectopic Pregnancy Managed Successfully By Minimally Invasive Treatment Using Local Methotrexate Injection and Systemic Methotrexate Administration: An Extremely Rare Case at Tu Du Hospital in Vietnam and literature review. [Case Reports]J Minim Invasive Gynecol. 2023 Jan 26 [Online ahead of print]JM
- Rectal Ectopic Pregnancy (REP) is one of the most extremely rare forms of ectopic pregnancy which strongly leads to maternal mortality higher than common types. An early diagnosis of unruptured REP remains a challenge and its management ought to be individualized depending on the clinical scenario. Currently, due to the paucity of data, there are no practical guidelines for an appropriate treatme…
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- Gancao Nourishing-Yin decoction combined with methotrexate in treatment of aging CIA mice: a study based on DIA proteomic analysis. [Journal Article]
- CONCLUSIONS: Aging aggravated joints damage in CIA, which probably due to metabolic changes rather than more severe inflammation. GCNY showed significant effects in the ERA mice model especially when integrated with MTX to obtain a synergic action.
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- Aseptic meningitis after amenamevir treatment for herpes zoster ophthalmicus with oculomotor nerve palsy in a patient taking immunosuppressant. [Case Reports]J Infect Chemother. 2023 Jan 25 [Online ahead of print]JI
- A 79-year-old woman presented with vomiting after being prescribed amenamevir by her primary care physician. She had a medical history of rheumatoid arthritis and was administered prednisolone and methotrexate. She was finally diagnosed with herpes zoster ophthalmicus and aseptic meningitis, and intravenous antiviral therapy was initiated. However, the patient developed oculomotor nerve palsy on …
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- Genome-wide association study of methotrexate-induced liver injury in rheumatoid arthritis patients. [Journal Article]Clin Pharmacol Ther. 2023 Jan 27 [Online ahead of print]CP
- Hepatotoxicity is a serious adverse drug reaction related to methotrexate (MTX). However, the cause of drug-induced liver injury (DILI) is still unclear and unpredictable. Genetic risk factors may predispose for MTX-DILI. Therefore, we conducted a nested case control genome-wide association study to explore genetic risk factors associated with MTX DILI. Seven international groups contributed bloo…
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- Five-year cardiovascular event risk in early rheumatoid arthritis patients who received treat-to-target management: a case-control study. [Journal Article]Rheumatology (Oxford). 2023 Jan 27 [Online ahead of print]R
- CONCLUSIONS: ERA patients managed by a T2T strategy did not develop excess CVE compared with CV risk factor-matched controls over 5 years.
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- Comedogenic lupus: a rare variant of chronic cutaneous lupus erythematosus - case series. [Journal Article]An Bras Dermatol. 2023 Jan 25 [Online ahead of print]AB
- CONCLUSIONS: Dermatologists should be aware of acneiform conditions with poor response to the usual treatment. Early diagnosis and treatment reduce the risk of unaesthetic scars.
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- Juvenile idiopathic arthritis in an adult Filipino female: A case report. [Journal Article]Int J Rheum Dis. 2023 Jan 27 [Online ahead of print]IJ
- CONCLUSIONS: JIA is a complicated disease which begins early in life and affects patients even in adulthood. These patients may suffer from arthritis with permanent joint deformities and uveitis, among other disabilities that make daily tasks impossible, impacting patients both mentally and socially.
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- Tripterygium wilfordii Hook F combination therapy with methotrexate for rheumatoid arthritis: An updated meta-analysis. [Journal Article]J Ethnopharmacol. 2023 Jan 24 [Online ahead of print]JE
- CONCLUSIONS: Combining TwHF with MTX may be a superior strategy in the treatment of RA compared with MTX monotherapy. The optimal combination of TwHF + MTX therapy might be TwHF at 30-60 mg/d with MTX (∼10 mg/w). Further high-quality double-blind RCTs may be able to change the conclusions of our study, which are still warranted.
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- Severe Recurrent Nocturnal Hypoglycemia During Chemotherapy With 6-mercaptopurine in 2 Children With Acute Lymphoblastic Leukemia. [Journal Article]J Pediatr Hematol Oncol. 2022 Dec 20 [Online ahead of print]JP
- Mercaptopurine (6MP) and methotrexate are the cornerstones of maintenance therapy in pediatric patients with acute lymphoblastic leukemia. However, although bone marrow suppression and liver dysfunction are common side effects of these antimetabolites, 6MP-induced hypoglycemia during the maintenance phase is rare. Guidelines and international protocols are well established for the management of b…
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- [18F]FDG PET/CT in a Case of Mycosis Fungoides Showing an Unusual Adverse Reaction to Mogamulizumab: Correlation Between Imaging and Histological Findings. [Journal Article]Cancer Biother Radiopharm. 2023 Jan 27 [Online ahead of print]CB
- A 73-year-old female patient, affected by mycosis fungoides (MF), discontinued mogamulizumab, after initial clinical benefit, due to the onset of generalized erythema. Follow-up positron emission computed tomography (PET/CTs) carried out at 3 weeks and 6 months after therapy discontinuation showed, with respect to baseline PET/CT scan, a progressively increasing number of hypermetabolic enlarged …
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- Shedding light on key pharmacological knowledge and strategies for pediatric atopic dermatitis. [Journal Article]Expert Rev Clin Pharmacol. 2023 Jan 27 [Online ahead of print]ER
- Atopic dermatitis (AD) is an inflammatory disease affecting over 20% of the pediatric population, with 85% of cases presenting before the age of five. Recently, therapeutic options in pediatric patients have evolved rapidly, following extensive development in adult treatments.
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- Hepatic failure in a patient with rheumatoid arthritis treated with methotrexate: A case report. [Case Reports]Medicine (Baltimore). 2023 Jan 27; 102(4):e32711.M
- CONCLUSIONS: Early diagnosis and immediate MTX discontinuation following NASH diagnosis and strict type 2 diabetes mellitus control might have prevented the irreversible progression of liver injury.
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- Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. [Case Reports]JNMA J Nepal Med Assoc. 2022 Oct 01; 60(254):902-905.JJ
- Vogt-Koyanagi-Harada disease is a multisystem autoimmune inflammatory disorder that affects the eyes, ears, skin, and the nervous system. It is a rare disease that mainly affects Asian, Hispanic, and Middle Eastern populations. Systemic steroids and immunosuppressants are frequently used to treat autoimmune diseases like this. Despite the fact that they reduce morbidity, immunosuppressants can ha…
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- Case Report of 59-Year-Old Woman with Bilateral Upper Limb Musculoskeletal Amyloid, Initially Diagnosed as Rheumatoid Arthritis. [Case Reports]Am J Case Rep. 2023 Jan 27; 24:e938582.AJ
- BACKGROUND Amyloid light-chain (AL) amyloidosis is usually due to deposition of immunoglobulin lambda light chains from plasma cells in patients with multiple myeloma. AL amyloid may involve the salivary glands, gastrointestinal tract, peripheral nerves, and skin. However, musculoskeletal amyloid and amyloid arthropathy are rare. This report is of a woman with bilateral upper limb musculoskeletal…
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- Waning humoral and cellular immunity after COVID-19 vaccination in patients with psoriasis treated with methotrexate and biologics: a cohort study. [Journal Article]Br J Dermatol. 2023 Jan 27 [Online ahead of print]BJ
- CONCLUSIONS: Treatment with anti-TNF has an impact on the immunity elicited by mRNA-based COVID-19 vaccination in patients with psoriasis, resulting in a faster waning of humoral and cellular markers of immunity, however, the clinical implications are unknown.
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- Why should we consider methotrexate in future trials of steroid-resistant immune thrombocytopenic purpura? - correspondence. [Letter]Immunol Lett. 2023 Jan 23 [Online ahead of print]IL
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- Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy. [Journal Article]J Control Release. 2023 Jan 27; 354:770-783.JC
- The poor cancer immunotherapy outcome has been closely related to immunosuppressive tumor microenvironment (TME), which usually inactivates the antitumor immune cells and leads to immune tolerance. Metalloimmunotherapy by supplementing nutritional metal ions into TME has emerged as a potential strategy to activate the tumor-resident immune cells. Herein, we engineered a magnesium-contained nano-a…
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