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59,724 results
  • An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis. [Journal Article]
    Drug Deliv. 2023 Dec; 30(1):2173332.Wang N, Ma J, … Zhao C
  • Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function. The therapeutic efficacy of RA treatments with the severely affected side remains unsatisfactory despite current treatment methods that primarily focus on anti-inflammatory activity, largely because of the complicatedly pathologica…
  • An Unusual Presentation of a Patient With Low-Dose Methotrexate Causing Colitis and Pancytopenia. [Case Reports]
    Cureus. 2022 Dec; 14(12):e33062.R R, Malic N, … Machani S
  • This paper summarizes the case of a patient admitted to the hospital due to methotrexate-induced colitis in the setting of pancytopenia. Although methotrexate is commonly used for a variety of diseases, this medication can precipitate side effects in a subset of patients. This is an atypical case of chronic low-dose methotrexate use leading to colitis and pancytopenia. It is of utmost significanc…
  • Diagnosis, treatment, and prognosis of primary intraocular lymphoma: Single-center real-world clinical experience. [Journal Article]
    Cancer Med. 2023 Jan 31 [Online ahead of print]Min GJ, Kim TY, … Cho SG
  • CONCLUSIONS: For PIOL, aggressive systemic treatment equivalent to that of primary CNS lymphoma (PCNSL) is recommended because solely HD-MTX did not prevent or delay CNS relapse. To prevent PIOL relapse in the CNS efficiently, prospective trials with large numbers of patients and advanced therapeutic regimens are necessary. Furthermore, regular clinical follow-up is crucial, and the IL-10/IL-6 ratio can help evaluate relapse promptly.
  • Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]
    Farm Hosp. 2023 Jan 27 [Online ahead of print]Ibarra Barrueta O, García Martín E, … Ais Larisgoitia A
  • CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
  • Genome-wide association study of methotrexate-induced liver injury in rheumatoid arthritis patients. [Journal Article]
    Clin Pharmacol Ther. 2023 Jan 27 [Online ahead of print]Eektimmerman F, Swen JJ, … Guchelaar HJ
  • Hepatotoxicity is a serious adverse drug reaction related to methotrexate (MTX). However, the cause of drug-induced liver injury (DILI) is still unclear and unpredictable. Genetic risk factors may predispose for MTX-DILI. Therefore, we conducted a nested case control genome-wide association study to explore genetic risk factors associated with MTX DILI. Seven international groups contributed bloo…
  • Juvenile idiopathic arthritis in an adult Filipino female: A case report. [Journal Article]
    Int J Rheum Dis. 2023 Jan 27 [Online ahead of print]Dorado CA, Vista ES
  • CONCLUSIONS: JIA is a complicated disease which begins early in life and affects patients even in adulthood. These patients may suffer from arthritis with permanent joint deformities and uveitis, among other disabilities that make daily tasks impossible, impacting patients both mentally and socially.
  • Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. [Case Reports]
    JNMA J Nepal Med Assoc. 2022 Oct 01; 60(254):902-905.Khatri S, Khatri S, … Singh AK
  • Vogt-Koyanagi-Harada disease is a multisystem autoimmune inflammatory disorder that affects the eyes, ears, skin, and the nervous system. It is a rare disease that mainly affects Asian, Hispanic, and Middle Eastern populations. Systemic steroids and immunosuppressants are frequently used to treat autoimmune diseases like this. Despite the fact that they reduce morbidity, immunosuppressants can ha…
  • Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy. [Journal Article]
    J Control Release. 2023 Jan 27; 354:770-783.Jia Y, Hu J, … Zhang L
  • The poor cancer immunotherapy outcome has been closely related to immunosuppressive tumor microenvironment (TME), which usually inactivates the antitumor immune cells and leads to immune tolerance. Metalloimmunotherapy by supplementing nutritional metal ions into TME has emerged as a potential strategy to activate the tumor-resident immune cells. Herein, we engineered a magnesium-contained nano-a…
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