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1,976 results
  • The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation. [Journal Article]
    Hum Exp Toxicol. 2022 Jan-Dec; 41:9603271221143029.Yilmaz H, Karakoc Y, … Yılmaz Rakıcı S
  • This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues through changes in biochemical and histopathological parameters in addition to contributions to the use of amifostine and RG in clinical studies. Five groups were established:…
  • Cardiotoxicity linked to anticancer agents and cardioprotective strategy. [Review]
    Arch Pharm Res. 2022 Oct; 45(10):704-730.Khairnar SI, Kulkarni YA, Singh K
  • Chemotherapy is a main treatment for cancer, and it benefits patients by controlling cancer relapse and metastasis, thereby leading to an increase in the overall survival rate. However, this treatment is associated with mild to severe side effects, one of which is cardiotoxicity. The severity of cardiotoxicity, a leading cause of cardiovascular diseases, depends on the type of cancer therapy empl…
  • An Adaptive Role for DNA Double-Strand Breaks in Hippocampus-Dependent Learning and Memory. [Review]
    Int J Mol Sci. 2022 Jul 28; 23(15)Weber Boutros S, Unni VK, Raber J
  • DNA double-strand breaks (DSBs), classified as the most harmful type of DNA damage based on the complexity of repair, lead to apoptosis or tumorigenesis. In aging, DNA damage increases and DNA repair decreases. This is exacerbated in disease, as post-mortem tissue from patients diagnosed with mild cognitive impairment (MCI) or Alzheimer's disease (AD) show increased DSBs. A novel role for DSBs in…
  • StatPearls: Radiation Esophagitis [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)Nesheiwat Z, Akbar H, … Mahajan KBOOK
  • Radiation esophagitis is inflammation of the esophagus due to radiation. Radiation esophagitis is typically an adverse effect that develops in individuals receiving radiation cancer therapy, most commonly for breast, lung, and other lymphomas. Symptoms present two to three weeks after the initial therapy and include throat pain, dysphagia, and the sensation that food is stuck. Amifostine is a med…
  • Repurposing of Various Current Medicines as Radioprotective Agents. [Journal Article]
    Anticancer Agents Med Chem. 2022 Apr 04 [Online ahead of print]Kaur R, Lang DK, … Saini B
  • CONCLUSIONS: Safety and risk-free treatment can be guaranteed with the repurposed agents. Agents like metformin, captopril, nifedipine, simvastatin, and various others have shown potent radioprotective action in various studies. This review compiled repurposed synthetic radioprotective agents.
  • Amifostine and rituximab in refractory immune thrombocytopaenia: A case series. [Journal Article]
    Vox Sang. 2022 Apr; 117(4):601-605.Choy J, Swe EPP, Shearer A
  • CONCLUSIONS: Three out of five patients achieved durable responses with amifostine and rituximab. Although there is confounding by rituximab, given its established low durable response rate, it is likely that the excellent long-term responses achieved were a result of amifostine. Clinical trials with larger patient cohorts and further investigation are required to confirm the efficacy and mechanism of amifostine in ITP.
  • HIF2 Regulates Intestinal Wnt5a Expression. [Journal Article]
    Front Oncol. 2021; 11:769385.García García CJ, Acevedo Diaz AC, … Taniguchi CM
  • Radiation therapy for abdominal tumors is challenging because the small intestine is exquisitely radiosensitive. Unfortunately, there are no FDA-approved therapies to prevent or mitigate GI radiotoxicity. The EGLN protein family are oxygen sensors that regulate cell survival and metabolism through the degradation of hypoxia-inducible factors (HIFs). Our group has previously shown that stabilizati…
  • Potential radioprotective properties of arbutin against ionising radiation on human leukocytes in vitro. [Journal Article]
    Mutat Res Genet Toxicol Environ Mutagen. 2021 Dec; 872:503413.Benković V, Marčina N, … Kopjar N
  • Arbutin is a simple phenolic glucoside biosynthesised in many plant families. Some of the everyday foods that contain arbutin are species of the genus Origanum, peaches, cereal products, coffee and tea and Arctostaphyllos uva ursi L. leaves. Arbutin possesses various beneficial effects in the organism, and was confirmed effective in the treatment of urinary tract infections as well as in preventi…
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