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12,284 results
  • Extracellular intersubunit interactions modulate epithelial Na+ channel gating. [Journal Article]
    J Biol Chem. 2023 Jan 14 [Online ahead of print]Zhang L, Wang X, … Kleyman TR
  • Epithelial Na+ channels (ENaCs) and related channels have large extracellular domains where specific factors interact and induce conformational changes, leading to altered channel activity. However, extracellular structural transitions associated with changes in ENaC activity are not well defined. Using crosslinking and two-electrode voltage clamp in Xenopus oocytes, we identified several pairs o…
  • A novel mechanism for T1R-independent taste responses to concentrated sugars. [Journal Article]
    J Neurosci. 2023 Jan 06 [Online ahead of print]Kalyanasundar B, Blonde GD, … Travers SP
  • Recent findings from our laboratory demonstrated that the rostral nucleus of solitary tract (rNST) retains some responsiveness to sugars in double-knockout mice lacking either the T1R1+T1R3 (KO1+3) or T1R2+T1R3 (KO2+3) taste receptor heterodimers. Here, we extended these findings in the parabrachial nucleus (PBN) of male and female KO1+3 mice using warm stimuli to optimize sugar responses and emp…
  • Liddle syndrome. [Journal Article]
    Vnitr Lek. 2022 Winter; 68(E-8):8-11.Mareš Š, Filipovský J
  • Liddle syndrome is an inherited form of arterial hypertension with autosomal dominant pattern of inheritance. It is caused by activating mutation of genes coding of the epithelial sodium channel in distal nephron. Mutation leads to excessive reabsorbtion of sodium ions and volume expansion resulting in arterial hypertension. Antoher typical laboratory findings are hypokalaemia, low levels of seru…
  • A case report of a young boy with low renin and high aldosterone levels induced by Liddle syndrome who was previously misdiagnosed with primary aldosteronism. [Case Reports]
    J Pediatr Endocrinol Metab. 2022 Dec 06 [Online ahead of print]Jin Y, Qiu W, Yao J
  • CONCLUSIONS: Adolescent hypertension may be secondary to underlying medical conditions affecting the heart, kidneys, or endocrine system or primary with no known underlying disease process. Although in an adolescent with hypertension, hyperaldosteronism, and low plasma renin activity, the initial diagnosis suggested primary hyperaldosteronism, the failure of aldosterone receptor antagonist's therapy led to the diagnosis of Liddle syndrome. Increased aldosterone levels should always be evaluated with caution before a definitive diagnosis to prevent misdiagnosis. Genetic testing is the gold standard for the diagnosis of Liddle syndrome. Early diagnosis and early precise treatment can restore normal blood pressure and prevent severe sequelae of chronic hypertension in patients.
  • Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4). [Review]
    J Physiol Sci. 2022 Nov 30; 72(1):31.Kasahara Y, Narukawa M, … Asakura T
  • The taste is biologically of intrinsic importance. It almost momentarily perceives environmental stimuli for better survival. In the early 2000s, research into taste reception was greatly developed with discovery of the receptors. However, the mechanism of salt taste reception is not fully elucidated yet and many questions still remain. At present, next-generation sequencing and genome-editing te…
  • Severe hyponatremia due to trimethoprim-sulfamethoxazole-induced SIADH. [Case Reports]
    SAGE Open Med Case Rep. 2022; 10:2050313X221132654.Marak C, Nunley M, … Ashraf A
  • Hyponatremia, a serum sodium level of <135 mEq/L, is the most common electrolyte abnormality occurring in 5%-35% of hospitalized patients. It is a predictor of increased morbidity and mortality. Diuretics, psychotropic, and antiepileptic drugs are commonly implicated in drug-induced hyponatremia. Trimethoprim-sulfamethoxazole and spironolactone are two commonly prescribed drugs; unfortunately, mo…
  • Blood-Brain Barrier Solute Carrier Transporters and Motor Neuron Disease. [Review]
    Pharmaceutics. 2022 Oct 11; 14(10)Latif S, Kang YS
  • Defective solute carrier (SLC) transporters are responsible for neurotransmitter dysregulation, resulting in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We provided the role and kinetic parameters of transporters such as ASCTs, Taut, LAT1, CAT1, MCTs, OCTNs, CHT, and CTL1, which are mainly responsible for the transport of essential nutrients, acidic, and basic drugs in…
  • Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells. [Journal Article]
    Front Physiol. 2022; 13:995473.Scarinci N, Perez PL, … Cantero MDR
  • Polycystin-2 (PC2, TRPP2) is a Ca2+ permeable nonselective cation channel whose dysfunction generates autosomal dominant polycystic kidney disease (ADPKD). PC2 is present in different cell locations, including the primary cilium of renal epithelial cells. However, little is known as to whether PC2 contributes to the primary cilium structure. Here, we explored the effect(s) of external Ca2+, PC2 c…
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