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11,735 results
  • Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes. [Journal Article]
  • FMFolia Med (Plovdiv) 2018 Jun 01; 60(2):241-247
  • Boyanov KO, Maneva AI
  • CONCLUSIONS: Wortmannin, quercetin, ouabain and amiloride increase cyclic AMP level in human platelets. Lactoferrin also increases cyclic AMP level, but the effect is statistically insignificant, which shows that lactoferrin does not participate directly in the cyclic AMP signaling. Lactoferrin additionally augments the stimulating action of wortmannin, quercetin, ouabain and amiloride on the cyclic AMP production. This probably shows a synergetic interference of lactoferrin in signal pathways along with phosphatidylinositol 3-kinase (wortmannin), quercetin (control over protein kinases, the redox state of the cell and ion transport), ouabain and amiloride (mechanisms of ion transport and phosphorylation).
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