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(aminocaproic acid)
5,813 results
  • LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom of Lycosa singoriensis. [Journal Article]
    Front Pharmacol. 2020; 11:896.Li P, Zhang Z, … Rong M
  • Spider venoms contain many functional proteins/peptides such as proteinases, serine/cysteine proteinase inhibitors, insecticidal toxins, and ion channel toxins. However, to date, no peptide toxin with procoagulant activities has been identified from spider venom. In this study, a novel toxin LCTX-F2 with coagulation-promoting activity was identified and characterized in the venom of the spider Ly…
  • Molecular and biochemical characterization of enolase from Dermanyssus gallinae. [Journal Article]
    Gene. 2020 Jun 20; 756:144911.Li H, Huang Y, … Pan B
  • Enolase, a multifunctional glycolytic enzyme, is known to act as a plasminogen receptor in many species, involved in the pivotal processes such as motility, adhesion, invasion, growth, and differentiation of the parasites. Knowledge on the function of enolase from Dermanyssus gallinae is very limited. Here we report on the molecular cloning, enzymatic activity, tissue distribution and plasminogen…
  • Impact of multidisciplinary engagement in a quality improvement blood conservation protocol for craniosynostosis. [Journal Article]
    J Neurosurg Pediatr. 2020 Jun 12 [Online ahead of print]Kurlander DE, Ascha M, … Tomei KL
  • CONCLUSIONS: Patients undergoing open calvarial vault remodeling procedures benefit from the input of a multidisciplinary stakeholder group in blood conservation protocols. Further research into comprehensive protocols for blood conservation may benefit from input from the full surgical team (plastic surgery, neurosurgery, anesthesiology) as well as additional pediatric subspecialty stakeholders including transfusion medicine, critical care, and hematology.
  • Cost-benefit analysis of tranexamic acid and blood transfusion in elective lumbar spine surgery for degenerative pathologies. [Journal Article]
    J Neurosurg Spine. 2020 Mar 20 [Online ahead of print]Ehresman J, Pennington Z, … Sciubba DM
  • CONCLUSIONS: TXA use was associated with decreased intraoperative blood loss and significant reductions in total hemostasis costs for patients undergoing surgery on more than 4 levels. Furthermore, the use of TXA in patients who received short constructs led to no additional net costs. With the increasing emphasis put on value-based care interventions, use of TXA may represent one mechanism for decreasing total care costs, particularly in the cases of larger spine constructs.
  • StatPearls: Aminocaproic Acid [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Kaseer Haya H UF Health Shands Hospital Sanghavi Devang D Mayo Clinic BOOK
  • Aminocaproic acid has received approval from the Food and Drug Administration (FDA) for the therapeutic management of acute hemorrhages caused by elevated fibrinolytic activity leading to surgical complications after cardiac surgery, hematological disorders, hepatic cirrhosis, and neoplastic disease. Indications also include the treatment of surgical and non-surgical hematuria.[1][2]
  • Biodegradable shape memory polymer foams with appropriate thermal properties for hemostatic applications. [Journal Article]
    J Biomed Mater Res A. 2020 Jun; 108(6):1281-1294.Jang LK, Fletcher GK, … Maitland DJ
  • Shape memory polymer (SMP) foams are a promising material for hemostatic dressings due to their biocompatibility, high surface area, excellent shape recovery, and ability to quickly initiate blood clotting. Biodegradable SMP foams could eliminate the need for a secondary removal procedure of hemostatic material from the patients' wound, further facilitating wound healing. In this study, we develo…
  • Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants. [Journal Article]
    Molecules. 2020 Jan 06; 25(1)Parfenova LV, Lukina ES, … Parfenov EV
  • Currently, significant attention is attracted to the problem of the development of the specific architecture and composition of the surface layer in order to control the biocompatibility of implants made of titanium and its alloys. The titanium surface properties can be tuned both by creating an inorganic sublayer with the desired morphology and by organic top coating contributing to bioactivity.…
  • Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power. [Journal Article]
    PLoS Comput Biol. 2020 01; 16(1):e1007600.Opuu V, Nigro G, … Simonson T
  • Designed enzymes are of fundamental and technological interest. Experimental directed evolution still has significant limitations, and computational approaches are a complementary route. A designed enzyme should satisfy multiple criteria: stability, substrate binding, transition state binding. Such multi-objective design is computationally challenging. Two recent studies used adaptive importance …
  • Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α. [Journal Article]
    Eur J Med Chem. 2020 Feb 01; 187:111967.Dai Y, Yue N, … Qian H
  • Proteolysis-targeting chimera (PROTAC) could selectively degrade target protein and may become a promising strategy for treating estrogen receptor α (ERα) positive breast cancers. Here, we designed penetrated peptide-based PROTACs by constructing an N-terminal lactam cyclic to improve proteolytic stability and cell penetration. We used a lactam cyclic peptide as ERα binding ligand, 6-aminocaproic…
  • Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity. [Journal Article]
    Biomol Ther (Seoul). 2020 Mar 01; 28(2):131-136.Cai M, Jung I, … Ryu JH
  • Hippocampal synaptic dysfunction is a hallmark of Alzheimer's disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy. In the present study, we investigated spinosin as a regulating agent of synaptic plasticity in AD. Spinosin attenuated amyloid β (Aβ)-induced long-term potentiation (LTP) imp…
  • Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase. [Journal Article]
    Mar Drugs. 2019 Nov 20; 17(12)Milito A, Brancaccio M, … Castellano I
  • Gamma-glutamyl transpeptidase (GGT) is a cell surface enzyme involved in glutathione metabolism and maintenance of redox homeostasis. High expression of GGT on tumor cells is associated with an increase of cell proliferation and resistance against chemotherapy. GGT inhibitors that have been evaluated in clinical trials are too toxic for human use. We have previously identified ovothiols, 5(Nπ)-me…
  • Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding. [Journal Article]
    J Med Chem. 2020 Feb 27; 63(4):1445-1472.Steinmetzer T, Pilgram O, … Wiedemeyer SJA
  • Hyperfibrinolytic situations can lead to life-threatening bleeding, especially during cardiac surgery. The approved antifibrinolytic agents such as tranexamic acid, ε-aminocaproic acid, 4-aminomethylbenzoic acid, and aprotinin were developed in the 1960s without the structural insight of their respective targets. Crystal structures of the main antifibrinolytic targets, the lysine binding sites on…
  • Stimulation of Phagocytic Activity in Cultured Human Corneal Fibroblasts by Plasminogen. [Journal Article]
    Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4205-4214.Sato T, Sugioka K, … Kusaka S
  • CONCLUSIONS: Plasminogen induced phagocytic activity in corneal fibroblasts in a manner dependent on its binding to the cell surface. This effect was not associated with increased production of proteases or IL-1β. Thus, plasminogen may promote the clearance of foreign particles or damaged tissue components by corneal fibroblasts early after tissue injury.
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