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(aminocaproic acid)
5,762 results
  • Tranexamic acid or epsilon-aminocaproic acid in total joint arthroplasty? A randomized controlled trial. [Journal Article]
    Bone Joint J 2019; 101-B(9):1093-1099Bradley KE, Ryan SP, … Bolognesi MP
  • CONCLUSIONS: For hip and knee arthroplasty procedures, EACA is associated with increased perioperative blood loss compared with TXA. However, there is no significant difference in transfusion rate. While further prospective studies are needed to compare the efficacy of each agent, we currently recommend orthopaedic surgeons to select their antifibrinolytic based on cost and regional availability. Cite this article: Bone Joint J 2019;101-B:1093-1099.
  • Inherited disorders of the fibrinolytic pathway. [Journal Article]
    Transfus Apher Sci 2019Jain S, Acharya SS
  • Deficiencies or excessive activation of the fibrinolytic system can result in severe, lifelong bleeding disorders. The most severe clinical phenotype is caused by α2-Antiplasmin (α2-AP) deficiency which results in excess fibrinolysis due to the inability to inhibit plasmin. Another bleeding disorder due to a defect in the fibrinolytic pathway results from Plasminogen activator inhibitor-1 (PAI-1)…
  • Venous stasis-induced fibrinolysis prevents thrombosis in mice: role of α2-antiplasmin. [Journal Article]
    Blood 2019Singh S, Houng A, Reed G
  • Stasis of venous blood triggers deep vein thrombosis by activating coagulation, yet its effects on the fibrinolytic system are not fully understood. We examined the relationship between stasis, fibrinolysis and the development of experimental venous thrombosis. Effects of stasis-induced deep vein thrombosis and fibrinolysis on thrombosis were examined by inferior vena cava ligation in congenic mi…
  • Epsilon-aminocaproic acid versus tranexamic acid in total knee arthroplasty: a meta-analysis study. [Review]
    J Orthop Traumatol 2019; 20(1):28Riaz O, Aqil A, … Radcliffe G
  • CONCLUSIONS: This study did not demonstrate TXA to be superior to EACA. In fact, both antifibrinolytic therapies demonstrated similar efficacy in terms of intra-operative blood loss, transfusion requirements and complication rates. Currently EACA has a lower cost, which makes it an appealing alternative to TXA for TKA surgery.
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