Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(aminocaproic acid)
5,995 results
  • 1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs. [Journal Article]
    Int J Mol Sci. 2022 Nov 29; 23(23)Bosch-Sanz O, Rabadà Y, … Sánchez-García D
  • Fibrinolysis is a natural process that ensures blood fluidity through the removal of fibrin deposits. However, excessive fibrinolytic activity can lead to complications in different circumstances, such as general surgery or severe trauma. The current antifibrinolytic drugs in the market, aminocaproic acid (EACA) and tranexamic acid (TXA), require high doses repetitively to maintain their therapeu…
  • Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug. [Journal Article]
    Sci Adv. 2022 11 18; 8(46):eabq5925.Rais R, Lemberg KM, … Slusher BS
  • 6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell metabolism but concurrently enhances the metabolic fitness of tumor CD8+ T cells. DON showed promising efficacy in clinical trials; however, its development was halted by dose-limiting gastrointestinal (GI) toxicities. Given its clinical potential, we designed DON peptide prodrugs and found DRP-104 [isopropyl(S…
  • Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage. [Review]
    Cochrane Database Syst Rev. 2022 11 09; 11:CD001245.Germans MR, Dronkers WJ, … Roos YB
  • CONCLUSIONS: The current evidence does not support the routine use of antifibrinolytic drugs in the treatment of people with aneurysmal subarachnoid haemorrhage. More specifically, early administration with concomitant treatment strategies to prevent delayed cerebral ischaemia does not improve clinical outcome. There is sufficient evidence from multiple randomised controlled trials to incorporate this conclusion in treatment guidelines.
  • StatPearls: Aminocaproic Acid [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)KaseerHayaHUF Health Shands HospitalSanghaviDevangDMayo ClinicBOOK
  • Aminocaproic acid, an antifibrinolytic agent, is a medication used to manage and treat acute bleeding disorders. This activity outlines the indications, mechanism of action, and contraindications for aminocaproic acid as a valuable agent in managing hyperfibrinolysis-induced hemorrhage. This activity will also highlight other key factors, including the adverse event profile, off-label indications…
  • Diagnosis and successful management of an extradural compressive hematoma secondary to diphacinone poisoning in a dog. [Case Reports]
    J Vet Emerg Crit Care (San Antonio). 2023 Jan; 33(1):101-106.Solari FP, Sherman AH, … Walton RA
  • CONCLUSIONS: This is the first reported case of a dog with an extradural hematoma secondary to anticoagulant rodenticide causing spinal cord compression and neurological deficits. Surgical management of this case was successful and resulted in improvement of neurological signs. Extradural hematoma should be considered as a potential location of bleeding in rodenticide toxicity as well as a differential diagnosis in patients with neurological deficits.
  • Ultrasmall polymer-coated cerium oxide nanoparticles as a traumatic brain injury therapy. [Journal Article]
    Nanomedicine. 2022 09; 45:102586.Kang DW, Cha BG, … Lee SH
  • No medication has been approved for secondary injuries after traumatic brain injury (TBI). While free radicals are considered a major mediator of secondary injury, conventional antioxidants only have modest clinical efficacy. Here, we synthesized CX201 consisting of core cerium oxide nanoparticles coated with 6-aminocaproic acid and polyvinylpyrrolidone in aqueous phase. CX201 with 3.49 ± 1.11 nm…
New Search Next