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(aminocaproic acid)
5,706 results
  • Local haemostatic measures after tooth removal in patients on antithrombotic therapy: a systematic review. [Journal Article]
  • COClin Oral Investig 2018 Aug 28
  • Ockerman A, Miclotte I, … Jacobs R
  • CONCLUSIONS: Tranexamic acid seems to effectively reduce bleeding, although its superiority to other haemostatics was not proven. In view of the rapidly changing landscape of antithrombotics and the lack of standardization of bleeding outcome, adequately powered clinical studies are required to optimise postoperative management in patients on antithrombotics.In order to optimise postoperative management, the best haemostatics over different patient groups have to be identified and implemented in guidelines.
  • Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions. [Review]
  • CDCochrane Database Syst Rev 2018 07 02; 7:CD012293
  • Engelen ET, Schutgens RE, … van Galen KP
  • CONCLUSIONS: Based on the results of this Cochrane Review, there seems to be a beneficial effect of locally applied TXA in preventing oral bleeding in people on continuous treatment with VKAs undergoing minor oral surgery or dental extractions. However, the small number of identified randomised controlled trials, the relatively small number of participants included in the trials and the differences in standard therapy and treatment regimens between trials, do not allow us to conclude definite efficacy of antifibrinolytic therapy in this population.We were unable to identify any eligible trials in people on continuous treatment with DOACs undergoing oral or dental procedures. Therefore, a beneficial effect of antifibrinolytic therapy can currently only be assumed based on data from the people using VKAs.
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