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Unbound Medicine.
(aminoglycosides)
179,028 results
  • Arabidopsis SMO2 modulates ribosome biogenesis by maintaining the RID2 abundance during organ growth. [Journal Article]
    Plant J. 2023 Jan 27 [Online ahead of print]Guo Z, Wang X, … Hu Z
  • Ribosome biogenesis is a process of making ribosomes that is tightly linked with plant growth and development. Here, through a suppressor screen for the smo2 mutant, we found that lack of a ribosomal stress response mediator, ANAC082 partially restored growth defects of the smo2 mutant, indicating SMO2 is required for the repression of nucleolar stress. Consistently, the smo2 knock-out mutant exh…
  • The primary pharmacology of ceftazidime/avibactam: resistance in vitro. [Journal Article]
    J Antimicrob Chemother. 2023 Jan 26 [Online ahead of print]Nichols WW, Lahiri SD, … Stone GG
  • This article reviews resistance to ceftazidime/avibactam as an aspect of its primary pharmacology, linked thematically with recent reviews of the basic in vitro and in vivo translational biology of the combination (J Antimicrob Chemother 2022; 77: 2321-40 and 2341-52). In Enterobacterales or Pseudomonas aeruginosa, single-step exposures to 8×  MIC of ceftazidime/avibactam yielded frequencies of r…
  • Analysis of prognostic factors and histopathological response to neoadjuvant chemotherapy in osteosarcoma. [Journal Article]
    Jt Dis Relat Surg. 2023; 34(1):196-206.Erdoğan F, Çinka H, … Dabak N
  • CONCLUSIONS: Metastasis at the time of diagnosis, <90% tumor necrosis, a tumor size of ≥10 cm, and metastasis development were significantly associated with poor survival and were found to be independent prognostic factors. The OS rate in the patient group with Stage III-IV response after neoadjuvant chemotherapy given the cisplatin + doxorubicin protocol was found to be better than those given the European and American Osteosarcoma Studies (EURAMOS) protocol. More research is needed to determine the most optimal chemotherapy protocols in this patient population. In addition, a multidisciplinary approach in treatment is of utmost importance to improve oncological outcomes.
  • Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3. [Journal Article]
    Oxid Med Cell Longev. 2023; 2023:9966355.Zhang W, Fan Z, … Huang C
  • Cardiotoxicity linked to doxorubicin (DOX) is primarily caused by inflammation, oxidative stress, and apoptosis. The role of tubeimoside I (TBM) in DOX-induced cardiotoxicity remains ambiguous, despite growing evidence that it could reduce inflammation, oxidative stress, and apoptosis in various diseases. This study was designed to investigate the role of TBM in DOX-induced cardiotoxicity and unc…
  • Characteristics of multiresistant Pseudomonas aeruginosa isolates from burn patients in Iran. [Journal Article]
    Acta Microbiol Immunol Hung. 2023 Jan 23 [Online ahead of print]Abednezhad A, Bakhshi B, … Mohammadi Barzelighi H
  • Infections caused by multidrug resistant (MDR) Pseudomonas aeruginosa isolates in burn patients restrict therapeutic strategies. The current study aimed to analyze antibiotic resistance genes and multilocus sequence typing (MLST) of P. aeruginosa strains isolated from burn patients in Shahid Motahari hospital in Tehran, Iran.Altogether 63 P. aeruginosa isolates were characterized in this study. A…
  • Glacier-Fed Stream Biofilms Harbor Diverse Resistomes and Biosynthetic Gene Clusters. [Journal Article]
    Microbiol Spectr. 2023 Jan 23 [Online ahead of print]Busi SB, de Nies L, … Battin T
  • Antimicrobial resistance (AMR) is a universal phenomenon the origins of which lay in natural ecological interactions such as competition within niches, within and between micro- to higher-order organisms. To study these phenomena, it is crucial to examine the origins of AMR in pristine environments, i.e., limited anthropogenic influences. In this context, epilithic biofilms residing in glacier-fe…
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