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(aminolevulinic acid )
8,107 results
  • Surgery of small anterior skull base meningiomas by endoscopic 5-aminolevulinic acid fluorescence-guidance (e- 5ALA- FGS): first clinical experiences. [Journal Article]
  • WNWorld Neurosurg 2018 Nov 09
  • Cornelius JF, Kamp MA, … Steiger HJ
  • CONCLUSIONS: Residual meningioma tissue on the far side of a key-hole approach, e.g. in the olfactory groove or at the optic canal is difficult to visualize. Visualization may be improved by an endoscope. So far, fluorescence-guidance by a microscope was limited by insufficient fluorescence signals in deep corridors. With a specially equipped 5-ALA fluorescence endoscope one may combine the advantages of both endoscopic vision and fluorescence-guidance. The present report demonstrates the usefulness of 5-ALA endoscopy for difficult to visualize areas.Endoscopic 5-ALA fluorescence guidance was shown to be feasible when resecting small and deep-seated skull base meningiomas via minimally invasive approaches. Based on this proof of principle, we encourage its evaluation for the middle or posterior fossa (e.g. internal auditory canal) and other difficult areas (behind neuro-vascular structures or the brainstem). Sensitivity and specificity of this method should be prospectively and systematically investigated.
  • Photodynamic therapy in the treatment of oral leukoplakia: a systematic review. [Review]
  • PPPhotodiagnosis Photodyn Ther 2018 Oct 31
  • Li Y, Wang B, … He Y
  • CONCLUSIONS: PDT seems to be a useful therapeutic strategy in the management of oral leukoplakia as a non-surgical treatment. Further RCTs with long follow-up period, standardized PDT parameters, and comparing efficacy of PDT with various therapies are expected to acquire definite conclusions.
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