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5,579 results
  • Use of Aminophylline to Reverse Acute Kidney Injury in Pediatric Critical Care Patients. [Journal Article]
    J Pediatr Pharmacol Ther. 2022; 27(8):739-745.Radel LJ, Branstetter J, … Rayburn MS
  • CONCLUSIONS: Based on these findings, aminophylline could be considered a potentially effective medication for use as rescue therapy in critically ill children with AKI. Limitations include small study population and retrospective nature. Further research in this area with a larger study population and a randomized control trial would allow for better characterization of the efficacy of aminophylline in reversal of AKI.
  • The diuretic effect of adding aminophylline or theophylline to furosemide in pediatric populations: a systematic review. [Review]
    Eur J Pediatr. 2023 Jan; 182(1):1-8.Van Siang Lian Mang P, Hui JC, … Ng KT
  • CONCLUSIONS: This is the first paper summarizing the evidence of combined use of furosemide with aminophylline/theophylline in pediatric population. Our systematic review demonstrated that the co-administration of furosemide and aminophylline/theophylline could potentially yield better diuretic effects of urine output and negative fluid balance than furosemide alone in pediatric patients with fluid overload. Given the substantial degree of heterogeneity and low level of evidence, future adequately powered trials are warranted to provide evidence regarding the combined use of aminophylline/theophylline and furosemide as diuretic in the pediatric population.
  • StatPearls: Aminophylline [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)Zafar GondalAnooshARawal Institute of Health SciencesZulfiqarHassamHRawalpindi Medical University & Allied HospitalsBOOK
  • Aminophylline is FDA-approved to treat reversible airway obstruction due to asthma or other chronic lung diseases. This activity illustrates the indications, mechanism of action, pharmacokinetics, and adverse effects of aminophylline. In addition, it stresses the role of health care providers in meticulously monitoring the drug concentrations to avoid toxicity owing to the narrow therapeutic inde…
  • Buccal caffeine strips for reversal of adverse symptoms of vasodilator stress. [Journal Article]
    J Nucl Cardiol. 2022 Jul 06 [Online ahead of print]Elsadany M, Stringer B, … Duvall WL
  • CONCLUSIONS: Buccal caffeine strips are a safe, well tolerated, and effective initial strategy to reverse adverse effects of vasodilator stress in the minority of patients who request it. Buccal caffeine alone or with IV rescue caffeine was highly effective in reversing adverse effects and was free of major adverse clinical events.
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