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- Cardiac autonomic modulation and long term use of amiodarone in patients with chronic chagasic cardiopathy. [Journal Article]
- PCPacing Clin Electrophysiol 2018 May 21
- CONCLUSIONS: The deviation in the sympatho-vagal balance and the increase in the complexity of HRV strongly suggest that amiodarone may have a cardioprotective effect, in addition to its anti-arrhythmic effects, which could increase the survival of these patients. This article is protected by copyright. All rights reserved.
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- Estimation and validation of acenocoumarol dosing algorithms in Bulgarian patients with cardiovascular diseases. [Journal Article]
- PMPer Med 2015; 12(3):209-220
- CONCLUSIONS: It was found that VKORC-1639G>A (25.5%), CYP2C9*2 (7.8%), CYP2C9*3 (6.1%), age (13.6%) and diagnosis (6.0%) significantly affected acenocoumarol dose variability in the derivation cohort. These factors with additional factors, such as sex (0.1%, p = 0.76), weight (2.6%, p = 0.14) and amiodarone use (3.0%, p = 0.059) accounted for 46.5% and 23.0% of the dose variability for genetic and clinical models, respectively.Based on the results of this investigation, validated clinical and pharmacogenetic algorithms for the prediction of a stable anticoagulant dose were developed, specifically designed for the Bulgarian population.
- Moving Beyond Beta-Blockers and Amiodarone: The Use of Anti-Inflammatories to Treat Post-Cardiac Surgery Atrial Fibrillation. [Editorial]
- JCJACC Clin Electrophysiol 2016; 2(1):86-88
- Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. [Review]
- BMBioorg Med Chem 2018 Mar 19
- Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finge...
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- Effect of Antiarrhythmic Drug Initiation on Readmission After Catheter Ablation for Atrial Fibrillation. [Journal Article]
- JCJACC Clin Electrophysiol 2015; 1(4):238-244
- CONCLUSIONS: Initiation of an AAD at discharge of catheter ablation is associated with a significant reduction in readmission within 90 days. Routine initiation of an AAD after catheter ablation may reduce healthcare utilization in the periablation period; however, the high rate of medication discontinuation may suggest that side effects or inefficacy may limit long-term AAD use post-ablation.
- Using statistical anomaly detection models to find clinical decision support malfunctions. [Journal Article]
- JAMIAJ Am Med Inform Assoc 2018 May 11
- CONCLUSIONS: Malfunctions/anomalies occur frequently in CDS alert systems. It is important to be able to detect such anomalies promptly. Anomaly detection models are useful tools to aid such detections.
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- Amiodarone for Suppression of Ventricular Tachycardia: When Less Is More. [Editorial]
- JCJACC Clin Electrophysiol 2017; 3(5):512-513
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- Amiodarone Discontinuation or Dose Reduction Following Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease. [Journal Article]
- JCJACC Clin Electrophysiol 2017; 3(5):503-511
- CONCLUSIONS: After successful VT ablation, as confirmed by noninducibility at the end of ablation and noninvasive programmed stimulation, amiodarone may be safely reduced/discontinued without an unacceptable increase in VT recurrence. Reduction/discontinuation of amiodarone should be considered an important goal of VT ablation.
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- The Antiarrhythmic Drug, Amiodarone, Decreases AKT Activity and Sensitizes Human Acute Myeloid Leukemia Cells to Apoptosis by ABT-263. [Journal Article]
- AJAm J Med Sci 2018; 355(5):488-496
- CONCLUSIONS: Overall, our findings suggest that combining K+ channel blockers with prosurvival Bcl-2 family inhibitors is a promising therapeutic approach in treating leukemia.
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- In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease. [Journal Article]
- JOJ Ophthalmol 2018; 2018:5315137
- CONCLUSIONS: These findings suggest that the corneal epithelial cells most likely endocytose amiodarone from the tear film in the amiodarone-induced keratopathy. In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells, and they differentiate and migrate to the center of the cornea to form the whorl pattern.
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