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Unbound Medicine.
(amiodarone)
11,852 results
  • Recurring episodes of bundle branch reentry ventricular tachycardia due to aortitis preceded by SARS-CoV-2 infection: a case report. [Case Reports]
    BMC Cardiovasc Disord. 2023 Jan 25; 23(1):46.Melchior SE, Schoos MM, … Melchior TM
  • CONCLUSIONS: We present a rare case of aortitis complicated with life-threatening ventricular tachycardia presided by Covid-19 infection without major respiratory symptoms. Given a known normal AV conduction prior to the COVID-19 infection, it seems likely that the ensuing aortitis in turn affected the septal myocardium, enabling the reentry tachycardia. Generally, bundle branch reentry tachycardia is best treated with radiofrequency ablation, but if it is due to aortitis with myocardial affection, long-term anti-inflammatory treatment is mandatory to prevent relapse and assure arrhythmia control. Our case highlights importance to recognize the existence of the multisystem inflammatory syndrome in adults (MIS-A) following COVID-19 infection in patients with alarming cardiovascular symptoms. The case shows that the early use of an CT-scan was crucial for both proper diagnosis and treatment option.
  • Elevation of Lipid Metabolites in Deceased Liver Donors Reflects Graft Suffering. [Journal Article]
    Metabolites. 2023 Jan 11; 13(1)Lee WC, Wu TJ, … Chan KM
  • Liver transplantation can be performed with deceased or living donor allografts. Deceased liver grafts are donated from brain- or circulation-death patients, and they have usually suffered from a certain degree of damage. Post-transplant graft function and patient survival are closely related to liver allograft recovery. How to define the damage of liver grafts is unclear. A total of 47 liver don…
  • High-Throughput Assessment of Real-World Medication Effects on QT Interval Prolongation: Observational Study. [Journal Article]
    JMIR Cardio. 2023 Jan 20; 7:e41055.Yuan N, Oesterle A, … Ouyang D
  • CONCLUSIONS: We demonstrate a new, high-throughput technique for monitoring real-world effects of QTc-prolonging medications from readily accessible clinical data. Using this approach, we confirmed known medications for QTc prolongation and identified potential new associations and demographic or comorbidity interactions that could supplement findings in curated databases. Our single-center results would benefit from additional verification in future multisite studies that incorporate larger numbers of patients and ECGs along with more precise medication adherence and comorbidity data.
  • Initial treatment strategies in new-onset atrial fibrillation in critically ill burn patients. [Journal Article]
    Int J Burns Trauma. 2022; 12(6):251-260.Suresh MR, Mills AC, … Rizzo JA
  • CONCLUSIONS: Conversion to sinus rhythm occurred more often in the rhythm-control group. Outcomes were otherwise similar in terms of mortality, complications, and adverse events. Hypotension occurred less frequently in the rhythm-control group, and although this difference was not significant, episodes of hypotension can have important clinical implications. Given these factors, along with burn patients having unique injury characteristics and a hypermetabolic state that may contribute to the development of NOAF, when choosing between rate- and rhythm control strategies, rhythm-control with amiodarone may be a better choice for managing NOAF in burn patients.
  • Predictors and impact of postoperative atrial fibrillation following thoracic surgery: a state-of-the-art review. [Review]
    Anaesthesia. 2023 Jan 11 [Online ahead of print]Diallo EH, Brouillard P, … Potter BJ
  • This review of 19 studies (39,783 patients) of atrial fibrillation after thoracic surgery addresses the pathophysiology, incidence, and consequences of atrial fibrillation in this population, as well as its prevention and management. Interestingly, atrial fibrillation was most often identified in patients not previously known to have the disease. Rhythm control with amiodarone was the most common…
  • Use of Therapeutic Drug Monitoring in Amiodarone Treatment: A Systematic Review of Recent Literature. [Journal Article]
    Ther Drug Monit. 2023 Jan 11 [Online ahead of print]Jørgensen AEM, Hermann TS, … Dalhoff KP
  • CONCLUSIONS: Because the antiarrhythmic effect of amiodarone is not correlated with blood concentrations and is easily detectable by electrocardiogram, the routine use of TDM in maintenance therapy is controversial, as evidenced by a scarcity of published literature in the recent decade. Furthermore, amiodarone toxicity is evident with normal/low amiodarone or MDEA levels; hence, TDM of amiodarone provides no therapeutic benefit to patients.
  • Epidemiology, Mechanisms, and Management of Atrial Fibrillation in Cardiac Amyloidosis. [Review]
    Curr Probl Cardiol. 2022 Dec 28; 48(4):101571.Bukhari S, Oliveros E, … Farmakis D
  • Cardiac amyloidosis (CA) is a restrictive disease that results from intramyocardial amyloid deposition due to immunoglobulin light chain or transthyretin proteins. Up to two-third of CA patients have atrial fibrillation (AF) due to electromechanical, autonomic, and hemodynamic disturbances. AF in CA carries particularly increased risk of thromboembolism, prompting anticoagulation therapy irrespec…
  • Safety and Efficacy of Prophylactic Amiodarone After Left Ventricular Assist Device. [Journal Article]
    ASAIO J. 2023 Jan 01; 69(1):96-100.Graboyes SDT, Kline TM, … Hollis IB
  • The prophylactic use of amiodarone to reduce the incidence of postoperative arrhythmias is effective for patients undergoing general cardiac surgeries; however, no data exists for the use of prophylactic amiodarone to prevent postoperative arrhythmias after CF-LVAD. This single-center, retrospective analysis compared patients with CF-LVADs placed between April 2014 and June 2020 who received prop…
  • Amiodarone-induced muscle tremor in an elderly patient: A case report. [Case Reports]
    World J Clin Cases. 2022 Dec 06; 10(34):12726-12733.Zhu XY, Tang XH, Yu H
  • CONCLUSIONS: Attention should be paid to the significance of the side effects of drugs in the elderly, which may be atypical in the elderly. The relevant side effects of drugs may not be as rare as reported due to individual differences and different pharmacokinetics. If the side effects are generated, the medication should be adjusted in time, and the progress of the side effects should be intervened.
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