- The Effect of Prophylactic Intravenous Amiodarone Administration on Reperfusion Ventricular Fibrillation in Patients With Left Ventricular Hypertrophy Undergoing Cardiopulmonary Bypass Surgery: Protocol for a Randomized Double-Blind Clinical Trial. [Journal Article]JMIR Res Protoc. 2023 Jan 27; 12:e40115.JR
- CONCLUSIONS: With this trial, we are hoping to demonstrate that prophylactic infusion of amiodarone before ACC release could reduce the occurrence of reperfusion VF in patients with LVH.
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- Amiodarone vs Dronedarone for Atrial Fibrillation: A Retrospective Cohort Study. [Journal Article]CJC Open. 2023 Jan; 5(1):8-14.CO
- CONCLUSIONS: In this incident cohort of patients hospitalized for atrial fibrillation, compared to those discharged on amiodarone, patients who received a dronedarone discharge prescription had an increase in the composite endpoint of recurrent CV-related hospitalization and death, over a median 1-year follow-up period.
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- Amiodarone vs. metoprolol succinate in HFrEF complicated with persistent atrial fibrillation with rapid ventricular response: A prospective observational study. [Journal Article]Front Cardiovasc Med. 2022; 9:1029012.FC
- CONCLUSIONS: In conclusion, in this prospective observational study, the amiodarone group had lower risk of cardiovascular death and the first hospitalization for HF than metoprolol in HFrEF and persistent atrial fibrillation (pAF) with RVR. The mechanism may be related to improved cardiac function, rhythm control and ventricular rate control.
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- Recurring episodes of bundle branch reentry ventricular tachycardia due to aortitis preceded by SARS-CoV-2 infection: a case report. [Case Reports]
- CONCLUSIONS: We present a rare case of aortitis complicated with life-threatening ventricular tachycardia presided by Covid-19 infection without major respiratory symptoms. Given a known normal AV conduction prior to the COVID-19 infection, it seems likely that the ensuing aortitis in turn affected the septal myocardium, enabling the reentry tachycardia. Generally, bundle branch reentry tachycardia is best treated with radiofrequency ablation, but if it is due to aortitis with myocardial affection, long-term anti-inflammatory treatment is mandatory to prevent relapse and assure arrhythmia control. Our case highlights importance to recognize the existence of the multisystem inflammatory syndrome in adults (MIS-A) following COVID-19 infection in patients with alarming cardiovascular symptoms. The case shows that the early use of an CT-scan was crucial for both proper diagnosis and treatment option.
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- Prevalence of Drug-Drug Interactions in Older Community-Dwelling Individuals: A Systematic Review and Meta-analysis. [Systematic Review]Drugs Aging. 2023 Jan 24 [Online ahead of print]DA
- CONCLUSIONS: DDIs are prevalent among older community-dwelling individuals; however, the methodology used to estimate these events varies considerably. A standardised methodology is needed to allow meaningful measurement and comparison of DDI prevalence.
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- The impact of underlying diseases-related drugs on the chronic kidney disease-associated pruritus in hemodialysis patients. [Journal Article]
- CONCLUSIONS: Atorvastatin was associated with decreased frequencies of CKD-aP among HD patients in our study. This knowledge may guide further clinical trials to evaluate atorvastatin's immunomodulatory and anti-inflammatory effects on the CKD-aP in HD populations.
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- Donor hyperoxia is a novel risk factor for severe cardiac primary graft dysfunction. [Journal Article]J Heart Lung Transplant. 2023 Jan 06 [Online ahead of print]JH
- CONCLUSIONS: Donor hyperoxia at heart recovery is a novel risk factor for severe primary graft dysfunction and early recipient death. These results suggest that excessive oxygen supplementation should be minimized during donor management.
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- Elevation of Lipid Metabolites in Deceased Liver Donors Reflects Graft Suffering. [Journal Article]
- Liver transplantation can be performed with deceased or living donor allografts. Deceased liver grafts are donated from brain- or circulation-death patients, and they have usually suffered from a certain degree of damage. Post-transplant graft function and patient survival are closely related to liver allograft recovery. How to define the damage of liver grafts is unclear. A total of 47 liver don…
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- High-Throughput Assessment of Real-World Medication Effects on QT Interval Prolongation: Observational Study. [Journal Article]JMIR Cardio. 2023 Jan 20; 7:e41055.JC
- CONCLUSIONS: We demonstrate a new, high-throughput technique for monitoring real-world effects of QTc-prolonging medications from readily accessible clinical data. Using this approach, we confirmed known medications for QTc prolongation and identified potential new associations and demographic or comorbidity interactions that could supplement findings in curated databases. Our single-center results would benefit from additional verification in future multisite studies that incorporate larger numbers of patients and ECGs along with more precise medication adherence and comorbidity data.
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- Initial treatment strategies in new-onset atrial fibrillation in critically ill burn patients. [Journal Article]
- CONCLUSIONS: Conversion to sinus rhythm occurred more often in the rhythm-control group. Outcomes were otherwise similar in terms of mortality, complications, and adverse events. Hypotension occurred less frequently in the rhythm-control group, and although this difference was not significant, episodes of hypotension can have important clinical implications. Given these factors, along with burn patients having unique injury characteristics and a hypermetabolic state that may contribute to the development of NOAF, when choosing between rate- and rhythm control strategies, rhythm-control with amiodarone may be a better choice for managing NOAF in burn patients.
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- Gastrointestinal bleeding during anticoagulation with direct oral anticoagulants compared to vitamin K antagonists. [Journal Article]
- Aim: Patients receiving oral anticoagulants with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) have an increased risk of gastrointestinal bleeding (GIB). We compared cases of GIB associated with VKAs and DOACs in terms of risk factors, scores, timing, location, severity, and outcome. Methods: Data from patients treated at a university hospital in Switzerland for GIB under VK…
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- Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy: The LEVO-D registry. [Journal Article]ESC Heart Fail. 2023 Jan 19 [Online ahead of print]EH
- CONCLUSIONS: In this large real-life series of AHF patients treated with levosimendan as destination therapy, we show a significant decrease of heart failure events during the year after the first administration. The simple LEVO-D Score could be of help when deciding about futile therapy in this population.
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- Amiodarone for the Prevention of Shocks and Death in Patients with Implantable Cardioverter-Defibrillators: Hero or Villain? [Editorial]Heart Rhythm. 2023 Jan 09 [Online ahead of print]HR
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- Association between rate of change in PaCO2 and functional outcome for patients with hypercapnia after out-of-hospital cardiac arrest: Secondary analysis of a randomized clinical trial. [Journal Article]Am J Emerg Med. 2023 Jan 05; 65:139-145.AJ
- CONCLUSIONS: For OHCA patients with hypercapnia on admission, the rate of change in PaCO2 was not independently associated with functional outcome; however, there was a significant trend that higher decreased rate was associated with increased hospital mortality.
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- Predictors and impact of postoperative atrial fibrillation following thoracic surgery: a state-of-the-art review. [Review]Anaesthesia. 2023 Jan 11 [Online ahead of print]A
- This review of 19 studies (39,783 patients) of atrial fibrillation after thoracic surgery addresses the pathophysiology, incidence, and consequences of atrial fibrillation in this population, as well as its prevention and management. Interestingly, atrial fibrillation was most often identified in patients not previously known to have the disease. Rhythm control with amiodarone was the most common…
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- Use of Therapeutic Drug Monitoring in Amiodarone Treatment: A Systematic Review of Recent Literature. [Journal Article]Ther Drug Monit. 2023 Jan 11 [Online ahead of print]TD
- CONCLUSIONS: Because the antiarrhythmic effect of amiodarone is not correlated with blood concentrations and is easily detectable by electrocardiogram, the routine use of TDM in maintenance therapy is controversial, as evidenced by a scarcity of published literature in the recent decade. Furthermore, amiodarone toxicity is evident with normal/low amiodarone or MDEA levels; hence, TDM of amiodarone provides no therapeutic benefit to patients.
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- Modeling and integrating interactions involving the CYP450 enzyme system in a multi-terminology server: Contribution to information extraction from a clinical data warehouse. [Journal Article]Int J Med Inform. 2023 Feb; 170:104976.IJ
- CONCLUSIONS: The HeTOP server contains a non-negligible number of relationships between drug components and CYP450 from multiple reference sources. These data allow us to query our Clinical Data Warehouse to highlight these cytochromic interactions. It would be interesting in the future to assess the actual clinical impact in hospital reports.
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- Amiodarone-induced phlebitis: Incidence and adherence to a clinical practice guideline. [Journal Article]Eur J Cardiovasc Nurs. 2023 Jan 03 [Online ahead of print]EJ
- CONCLUSIONS: A large proportion of the patients developed amiodarone-induced phlebitis. The adherence to the clinical practice guideline was not optimal according to the PIVC recommendations. Prevention of amiodarone-induced phlebitis should have high priority to reduce patient harm.
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- Early amiodarone pneumonitis: A case report. [Case Reports]
- Consider amiodarone pneumonitis as an important differential diagnosis of ARDS, especially in clinically ill patients who recently received Intravenous amiodarone.
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- Meta‑analysis of the efficacy and safety of nifekalant in the conversion of atrial fibrillation. [Journal Article]
- Atrial fibrillation (AF) is the most common type of supraventricular tachyarrhythmia. Nifekalant is a new class III antiarrhythmic drug approved for the treatment of ventricular tachyarrhythmias, but its effectiveness in converting AF to sinus rhythm remains unclear. The present analysis aimed to investigate the effect of nifekalant in the conversion of AF. PubMed, Cochrane Library and China Nati…
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- Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. [Journal Article]Cell Biol Toxicol. 2022 Dec 31 [Online ahead of print]CB
- Transcriptomic analysis is a powerful method in the utilization of New Approach Methods (NAMs) for identifying mechanisms of toxicity and application to hazard characterization. With this regard, mapping toxicological events to time of exposure would be helpful to characterize early events. Here, we investigated time-dependent changes in gene expression levels in iPSC-derived renal proximal tubul…
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- Real-life data on the impact of medical therapy for amiodarone-induced thyrotoxicosis on CV events and hospitalizations. [Journal Article]J Clin Endocrinol Metab. 2022 Dec 31 [Online ahead of print]JC
- CONCLUSIONS: The first medical therapy of AIT influences the exposure time to thyrotoxicosis and the occurrence of cardiovascular events and hospitalizations.
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- Epidemiology, Mechanisms, and Management of Atrial Fibrillation in Cardiac Amyloidosis. [Review]Curr Probl Cardiol. 2022 Dec 28; 48(4):101571.CP
- Cardiac amyloidosis (CA) is a restrictive disease that results from intramyocardial amyloid deposition due to immunoglobulin light chain or transthyretin proteins. Up to two-third of CA patients have atrial fibrillation (AF) due to electromechanical, autonomic, and hemodynamic disturbances. AF in CA carries particularly increased risk of thromboembolism, prompting anticoagulation therapy irrespec…
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- Safety and Efficacy of Prophylactic Amiodarone After Left Ventricular Assist Device. [Journal Article]ASAIO J. 2023 Jan 01; 69(1):96-100.AJ
- The prophylactic use of amiodarone to reduce the incidence of postoperative arrhythmias is effective for patients undergoing general cardiac surgeries; however, no data exists for the use of prophylactic amiodarone to prevent postoperative arrhythmias after CF-LVAD. This single-center, retrospective analysis compared patients with CF-LVADs placed between April 2014 and June 2020 who received prop…
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- Stellate ganglion blockade combined with nifekalant for patients with electrical storm: a case report. [Case Reports]
- Although both stellate ganglion blockade and nifekalant are effective treatment options for electrical storm, the clinical effect of their combination is uncertain.
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- Programmed ventricular stimulation in structural heart disease: Implications of patterns of ventricular arrhythmias induced to long-term outcomes. [Journal Article]Indian Heart J. 2022 Dec 26 [Online ahead of print]IH
- CONCLUSIONS: Induction of monomorphicVT/polymorphicVT with ≤3extrastimuli is associated with a higher number of MACE events on follow up. Induction of monomorphicVT predicts recurrence of VT/ICD shock.
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- Amiodarone-induced muscle tremor in an elderly patient: A case report. [Case Reports]
- CONCLUSIONS: Attention should be paid to the significance of the side effects of drugs in the elderly, which may be atypical in the elderly. The relevant side effects of drugs may not be as rare as reported due to individual differences and different pharmacokinetics. If the side effects are generated, the medication should be adjusted in time, and the progress of the side effects should be intervened.
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- A case of refractory ventricular fibrillation after caffeine poisoning successfully treated by supportive care. [Case Reports]
- Caffeine (1,3,7-trimethylxantine), a structural analog of adenosine, is widely used as a central nervous system stimulant in beverages and drugs. Caffeine overdose induces hypokalemia, fatal ventricular fibrillation, and cardiac arrest, resulting in death. We describe a case of caffeine overdose that presented with refractory ventricular fibrillation that was treated with supportive care because …
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- Landscape of Druggable Molecular Pathways Downstream of Genomic CDH1/Cadherin-1 Alterations in Gastric Cancer. [Journal Article]
- Loss of CDH1/Cadherin-1 is a common step towards the acquisition of an abnormal epithelial phenotype. In gastric cancer (GC), mutation and/or downregulation of CDH1/Cadherin-1 is recurrent in sporadic and hereditary diffuse GC type. To approach the molecular events downstream of CDH1/Cadherin-1 alterations and their relevance in gastric carcinogenesis, we queried public databases for genetic and …
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- Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. [Journal Article]
- (1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was p…
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