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10,301 results
  • Estimation and validation of acenocoumarol dosing algorithms in Bulgarian patients with cardiovascular diseases. [Journal Article]
  • PMPer Med 2015; 12(3):209-220
  • Tzveova R, Dimitrova-Karamfilova A, … Kaneva R
  • CONCLUSIONS: It was found that VKORC-1639G>A (25.5%), CYP2C9*2 (7.8%), CYP2C9*3 (6.1%), age (13.6%) and diagnosis (6.0%) significantly affected acenocoumarol dose variability in the derivation cohort. These factors with additional factors, such as sex (0.1%, p = 0.76), weight (2.6%, p = 0.14) and amiodarone use (3.0%, p = 0.059) accounted for 46.5% and 23.0% of the dose variability for genetic and clinical models, respectively.Based on the results of this investigation, validated clinical and pharmacogenetic algorithms for the prediction of a stable anticoagulant dose were developed, specifically designed for the Bulgarian population.
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