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6,184 results
  • Enzymatic synthesis of amlodipine amides and evaluation of their anti-Trypanosoma cruzi activity. [Journal Article]
    Org Biomol Chem. 2023 Jan 26 [Online ahead of print]Elso OG, Bivona AE, … García Liñares G
  • Advancing with our project about the development of new antiparasitic agents, we have enzymatically synthesized a series of amides derived from amlodipine, a calcium channel blocker used as an antihypertensive drug. Through lipase-catalyzed acylation with different carboxylic acids, nineteen amlodipine derivatives were obtained, eighteen of which were new compounds. To optimize the reaction condi…
  • Treatment of Gingival Growth Due to Amlodipine Use With a 445-nm Diode Laser: A Case Report. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32592.Okumuş ÖF
  • Amlodipine is a widely used calcium channel blocker associated with gingival enlargement. The effects of amlodipine on gingival enlargement vary depending on the duration of drug use and the dose of the active substance. This report presents a 56-year-old male hypertensive patient who had been using amlodipine (5 mg/day orally, single dose) for the last two years. He presented with diffuse gingiv…
  • Silica associated systemic sclerosis: an occupational health hazard. [Case Reports]
    BMJ Case Rep. 2023 Jan 17; 16(1)Shivakumar DS, Kamath NS, Naik A
  • A middle-aged male working in the sandblasting and stone-cutting industry was brought to the medicine department with skin tightness, dysphagia and discolouration of the skin for the last 1 year. On examination, he had skin thickening over the face and the extremities with restricted mouth opening. His hands were cold and showed peripheral cyanosis. Systemic examination was suggestive of diffuse …
  • Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures-A Protocol Suggestion. [Review]
    Int J Mol Sci. 2023 Jan 03; 24(1)Pálovics E, Madarász J, … Bánhegyi DF
  • In this review, we aim to present new concepts for the revisited separation of enantiomers from racemic compounds and a protocol worth to be followed in designing the preparation of pure enantiomers. We have taken into account not only the influence of the properties (eutectic composition) and characteristics of the reactants (racemic compound, resolving agent), but also the behavior of the resul…
  • Mathematical modeling of antihypertensive therapy. [Journal Article]
    Front Physiol. 2022; 13:1070115.Kutumova E, Kiselev I, … Kolpakov F
  • Hypertension is a multifactorial disease arising from complex pathophysiological pathways. Individual characteristics of patients result in different responses to various classes of antihypertensive medications. Therefore, evaluating the efficacy of therapy based on in silico predictions is an important task. This study is a continuation of research on the modular agent-based model of the cardiov…
  • Rapid determination of polyethoxylated tallow amine surfactants in human plasma by LC-MSMS. [Journal Article]
    Talanta. 2023 Mar 01; 254:124115.Qiang S, Mohamed F, … Roberts MS
  • The potential exposure to the widely used glyphosate-based herbicides, including attempted suicide by ingestion, is of world-wide concern. Whilst the major focus to date has been on managing exposure to the active ingredient glyphosate, it is now recognised that a common major 'inert' surfactant ingredient, polyethoxylated tallow amine (POEA) and related compounds, may be more toxic. However, the…
  • Geriatric Pharmacotherapy Case Series: Thiazide-Induced Hypokalemia. [Case Reports]
    Sr Care Pharm. 2022 Dec 01; 37(12):605-611.Burka AT, Geiger DW
  • Introduction The patient was a 72-year-old man with a history of hypertension, hyperlipidemia, benign prostatic hyperplasia, and oropharyngeal cancer. His home medications include amlodipine, atorvastatin, hydrochlorothiazide, and tamsulosin. He lives alone and eats a soft, bland, nutrient-poor diet. During his annual primary care visit, he is found to have a serum potassium level of 3.3 mEq/L (r…
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