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5,135 results
  • Evaluation of Non-Crystalline Cellulose as a Novel Excipient in Solid Dose Products. [Journal Article]
  • DDDrug Dev Ind Pharm 2018 May 08; :1-32
  • Pawar KR, Render D, … Babu RJ
  • CONCLUSIONS: MCC, although a widely used tablet excipient, has diasdvantages in terms of its low dilution potential for potent drugs, and sensitivity to lubricant and moisture. SMCC, a modified version of MCC, has improved tablet compression properties. However, SMCC is expensive and also affects the moisture sorption and particle deformation during compression leading to increased tensile strength and tablet hardness. NCC was found to be similar to SMCC in its performance as a tablet excipient and thus can serve as a cheaper alternative to SMCC.Based on the data, it can be concluded that NCC can serve as a cheaper and better alternative to MCC as excipient in solid dosage forms.
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