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456 results
  • StatPearls: Amoxapine [BOOK]
    StatPearls Publishing: Treasure Island (FL) Abbas Sayeda S Avalon University School of Medicine Marwaha Raman R Case Western Reserve Un/MetroHealth MC BOOK
  • Amoxapine is FDA approved drug belonging to the class of second-generation tricyclic dibenzoxazepine antidepressants.[1][2] It is generally reserved for second or third line treatment after selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRI) has failed to control the depression.[1] Thus, it is indicated for treatment-resistant depression, after t…
  • Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. [Journal Article]
    Mol Psychiatry 2019; 24(4):501-522Niculescu AB, Le-Niculescu H, … White FA
  • We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of pain. For discovery, we used a powerful within-subject longitudinal design. We we…
  • Antidepressants in epilepsy. [Review]
    Neurol Neurochir Pol 2018 Nov - Dec; 52(6):657-661Górska N, Słupski J, … Gałuszko-Węgielnik M
  • People with epilepsy (PWE) frequently suffer from comorbid mood and anxiety disorders. Depression is one of the major psychiatric comorbidities having a negative impact on the quality of life in people with epilepsy. A review of the literature indicates that the majority of antidepressant-related seizures have been associated with either ultra-high doses or overdosing and, generally, the risk of …
  • Salts of Amoxapine with Improved Solubility for Enhanced Pharmaceutical Applicability. [Journal Article]
    ACS Omega 2018; 3(2):2406-2416Joshi M, Roy Choudhury A
  • The objective of pharmaceutical cocrystallization is to create crystalline analogues that have vastly different properties, such as solubility, melting point, stability, and bioavailability from that observed in the pure active pharmaceutical ingredients (APIs). Amoxapine is a benzoxazepine derivative and exhibits antidepressant properties. Amoxapine has very low solubility in water, so it was co…
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