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46,607 results
  • D2 autoreceptor switches CB2 receptor effects on [3 H]-dopamine release in the striatum. [Journal Article]
    Synapse 2019; :e22139López-Ramírez G, Sánchez-Zavaleta R, … Florán B
  • CB2 receptors (CB2 R) are expressed in midbrain neurons. To evidence the control of dopamine release in dorsal striatum by CB2 R, we performed experiments of [3 H]-dopamine release in dorsal striatal slices. We found a paradoxical increase in K+ -induced [3 H]-dopamine release by CB2 R activation with GW 833972A and JWH 133 two selective agonist. To understand the mechanism involved, we tested fo…
  • Gender Differences in Smoking Among an Urban Emergency Department Sample. [Journal Article]
    Tob Use Insights 2019; 12:1179173X19879136Cunradi CB, Lee J, … Alter HJ
  • CONCLUSIONS: Emergency department staff should consider the impact of polysubstance use, food insufficiency, unemployment, and whether both partners in the couple smoke when screening patients for smoking and formulating cessation treatment plans. Women in same-gender relationships and those who have experienced IPV involvement may require additional referral.
  • Newly Emerging Drugs of Abuse. [Journal Article]
    Handb Exp Pharmacol 2019Tamama K, Lynch MJ
  • Drug use and the associated overdose deaths have been a serious public health threat in the United States and the world. While traditional drugs of abuse such as cocaine remain popular, recreational use of newer synthetic drugs has continued to increase, but the prevalence of use is likely underestimated. In this review, epidemiology, chemistry, pharmacophysiology, clinical effects, laboratory de…
  • Foraging theory and the propensity to be obese: an alternative to thrift. [Journal Article]
    Homo 2019Baig U, Lokhande L, … Watve M
  • The evolutionary origin of obesity is classically believed to be genetic or developmentally induced thrift, as an adaptation to ancestral feast and famine conditions. However, recently the thrift family of hypotheses have attracted serious criticism necessitating alternative thinking. Optimization of foraging behaviour is an important aspect of behavioural evolution. For a species evolved for opt…
  • Two-dimensional tandem mass spectrometry in a single scan on a linear quadrupole ion trap. [Journal Article]
    Anal Chem 2019Snyder DT, Szalwinski LJ, … Cooks RG
  • A two-dimensional tandem mass spectrometry (2D MS/MS) scan has been developed for the linear quadrupole ion trap. Precursor ions are mass-selectively excited using a nonlinear ac frequency sweep at constant rf voltage while, simultaneously, all product ions of the excited precursor ions are ejected from the ion trap using as broadband waveform. The fragmentation time of the precursor ions correla…
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