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Unbound Medicine.
(amphetamine mixtures)
169 results
  • Enantioselective separation of Novel Psychoactive Substances using a Lux® AMP 3 μm column and HPLC-UV. [Journal Article]
    J Pharm Biomed Anal. 2020 Feb 05; 179:112967.Hägele JS, Basrak M, Schmid MG
  • The abuse of Novel Psychoactive Substances (NPS) still cause severe problems. A lot of them contain a stereogenic centre which leads to possible different pharmacological effects of the enantiomers. The aim of this study was to establish an enantioselective HPLC-UV method with applicability to a broad spectrum of NPS. Different compound classes including mainly amphetamines, cathinones, ketamines…
  • Mix of new substances psychoactive, NPS, found in blotters sold in two Colombian cities. [Journal Article]
    Forensic Sci Int. 2019 Nov; 304:109969.Mendoza-Valencia CY, Mariño Gaviria DJ, … Trespalacios Rodríguez D
  • The new psychoactive substances (NPS) in Colombia are detected by national authorities, in blotters strip, in different circumstances and places: airports, music concerts, discos and parks. Blotters are marketed as LSD and cause several cases of intoxication and death in some consumers: due to acute intoxication or when mixed with other drugs and may have different effects on the central nervous …
  • Aquatic Phytotoxicity to Lemna minor of Three Commonly Used Drugs of Addiction in Australia. [Journal Article]
    Bull Environ Contam Toxicol. 2019 Nov; 103(5):710-716.Yadav MK, Kumar A, … Saint CP
  • The manufacturing and consumption of drugs of addiction has increased globally and their widespread occurrence in the environment is an emerging concern. This study evaluated the phytotoxicity of three compounds: methamphetamine, codeine and morphine; commonly reported in Australian urban water, to the aquatic plant Lemna minor under controlled conditions. L. minor was sensitive to lower drug con…
  • A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse. [Review]
    J Clin Med. 2019 Aug 23; 8(9)Tsatsakis A, Docea AO, … Neagu M
  • Drugs of abuse are associated with stroke, especially in young individuals. The major classes of drugs linked to stroke are cocaine, amphetamines, heroin, morphine, cannabis, and new synthetic cannabinoids, along with androgenic anabolic steroids (AASs). Both ischemic and hemorrhagic stroke have been reported due to drug abuse. Several common mechanisms have been identified, such as arrhythmias a…
  • Logical MS/MS scans: a new set of operations for tandem mass spectrometry. [Journal Article]
    Analyst. 2018 Nov 05; 143(22):5438-5452.Snyder DT, Szalwinski LJ, … Cooks RG
  • A new set of operations for tandem mass spectrometry in a linear ion trap is described. Logical MS/MS operations categorize compounds in mixtures based on characteristic structural features as revealed by MS/MS behavior recorded in multiple fragmentation pathways. This approach is a conceptual extension of tandem mass spectrometry in which interrogation of the full data domain is performed by sim…
  • Detection and identification of designer drugs by nanoparticle-based NMR chemosensing. [Journal Article]
    Chem Sci. 2018 Jun 07; 9(21):4777-4784.Gabrielli L, Rosa-Gastaldo D, … Mancin F
  • Properly designed monolayer-protected nanoparticles (2 nm core diameter) can be used as nanoreceptors for selective detection and identification of phenethylamine derivatives (designer drugs) in water. The molecular recognition mechanism is driven by the combination of electrostatic and hydrophobic interactions within the coating monolayer. Each nanoparticle can bind up to 30-40 analyte molecules…
  • A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania. [Journal Article]
    Int J Neuropsychopharmacol. 2018 05 01; 21(5):473-484.Liebenberg N, Jensen E, … Wegener G
  • CONCLUSIONS: Casein glycomacropeptide-based treatments and a branched-chain amino acid mixture affected total tissue levels of dopamine in the frontal cortex and striatum and serotonin in the frontal cortex, striatum, and hippocampus of rats in a time-dependent fashion and displayed antimanic efficacy in a behavioral assay of mania.
  • Chemometrics-assisted chromatographic fingerprinting: An illicit methamphetamine case study. [Journal Article]
    J Sep Sci. 2017 Mar; 40(6):1318-1326.Shekari N, Vosough M, Tabar Heidar K
  • The volatile chemical constituents in complex mixtures can be analyzed using gas chromatography with mass spectrometry. This analysis allows the tentative identification of diverse impurities of an illicit methamphetamine sample. The acquired two-dimensional data of liquid-liquid extraction was resolved by multivariate curve resolution alternating curve resolution to elucidate the embedded peaks …
  • Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer. [Journal Article]
    Mass Spectrom (Tokyo). 2015; 4(1):A0038.Kumano S, Sugiyama M, … Hashimoto Y
  • We previously reported on the development of a portable mass spectrometer for the onsite screening of illicit drugs, but our previous sampling system could only be used for liquid samples. In this study, we report on an attempt to develop a probe heating method that also permits solid samples to be analyzed using a portable mass spectrometer. An aluminum rod is used as the sampling probe. The pow…
  • Electrochemical simulation of cocaine metabolism-a step toward predictive toxicology for drugs of abuse. [Journal Article]
    Eur J Mass Spectrom (Chichester). 2014; 20(4):279-85.Mielczarek P, Raoof H, … Silberring J
  • Knowledge of the metabolic pathways and biotransformation of the most popular drugs, such as cocaine, amphetamine, morphine and others, is crucial for the elucidation of their possible toxicity and mechanism of action in the human body. In vitro studies on metabolism are mainly based on the incubation of drugs with liver celL homogenate and utilizing Living animals. These methods need to be follo…
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