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Unbound Medicine.
(amphetamine mixtures)
507 results
  • Drugs and Lactation Database (LactMed): Amphetamine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • In dosages prescribed for medical indications, some evidence indicates that amphetamine does not affect nursing infants adversely. The effect of amphetamine in milk on the neurological development of the infant has not been well studied. Large dosages of amphetamine might interfere with milk production, especially in women whose lactation is not well established. Breastfeeding is generally discou…
  • Uncovering cloves: characterization of volatile compounds present in clove cigarettes. [Journal Article]
    Toxicol Res (Camb). 2022 Dec; 11(6):987-1002.Picanço JMA, Limberger RP, Apel MA
  • Indonesian clove cigarettes-called "kretek" due to the crackling sound that can be heard when the product burns-are tobacco products containing clove and the "saus", a mixture of essential oils and plant extracts whose ingredients are mostly kept in secret. It is important to determine which ingredients those are to properly assess the effects that clove cigarettes can cause. An organoleptic, qua…
  • Can scene bloodstains be used to quantify drug concentration at the moment of injury? [Journal Article]
    Forensic Sci Int. 2022 Dec; 341:111498.Adamowicz P, Ziora B
  • Blood is the primary material for quantitative toxicological analysis and interpretation of the results. However, in some cases like hit-and-run, it may be collected after a long time since the incident, resulting in the complete elimination or a significant decrease in the concentrations of potentially present drugs. If the suspect was injured and bloodstains were revealed, they can become the b…
  • Portable near infrared spectroscopy for the isomeric differentiation of new psychoactive substances. [Journal Article]
    Forensic Sci Int. 2022 Dec; 341:111467.Kranenburg RF, Ramaker HJ, van Asten AC
  • Rapid and efficient identification of the precise isomeric form of new psychoactive substances (NPS) by forensic casework laboratories is a relevant challenge in the forensic field. Differences in legal status occur for ring-isomeric species of the same class, thus leading to different penalties and judicial control. Portable systems such as near-infrared (NIR) spectroscopy recently emerged as su…
  • StatPearls: Prescription of Controlled Substances: Benefits and Risks [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)PreussCharles V.CVUniversity of South FloridaKalavaArunAUniversity of South FloridaKingKevin C.KCBOOK
  • One of the single most difficult challenges for any prescriber is to distinguish between the legitimate prescription of controlled substances versus the prescription potentially used for illegitimate purposes. To discern the difference, prescribers need to understand the signs, symptoms, and treatment of acute and chronic pain as well as the signs and symptoms of patients misusing controlled subs…
  • Quantification of mixtures of analogues of illicit substances by benchtop NMR spectroscopy. [Journal Article]
    J Magn Reson. 2022 02; 335:107138.Lee Y, Matviychuk Y, … Holland DJ
  • This paper investigates the possibility of using benchtop NMR spectroscopy for quantification of illicit drugs (methamphetamine) in binary and ternary mixtures with impurities and cutting agents (N-isopropylbenzylamine, phenethylamine and dimethylsulfone). To avoid handling regulated substances, methamphetamine in our experiments is substituted with amino-2-propanol, which has similar functional …
  • Analysis of drug residue in needle-exchange syringes in Washington, D.C. [Journal Article]
    Forensic Sci Int. 2021 Dec; 329:111083.Evans A, Krause M, … Short LC
  • For the first time in Washington, D.C., an analysis of drug residue from used needle-exchange syringes has been performed. This analysis is part of a larger initiative to understand the District of Columbia's illicit drug supply and its intravenous (IV) user's consumption trends as our nation faces the opioid epidemic. The goal of this study is to develop a more comprehensive monitoring program t…
  • Enantioselective determination of plasma protein binding of common amphetamine-type stimulants. [Journal Article]
    J Pharm Biomed Anal. 2021 Oct 25; 205:114317.Losacker M, Roehrich J, Hess C
  • Amphetamine-type stimulants (ATS) like amphetamine ('speed'), methamphetamine ('crystal meth') and 3,4-methylenedioxy-N-methylamphetamine (MDMA, 'ecstasy') represent some of the most frequently abused drugs worldwide. Another less frequently abused ATS is 4-fluoroamphetamine (4-FA). The enantiomers of these four compounds exhibit different pharmacokinetic and pharmacodynamic properties. According…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Attention Deficit/Hyperactivity Disorder (ADHD) Agents [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Attention deficit/hyperactivity disorder (ADHD) is neurodevelopment condition marked by variable degrees of inattention, inability to concentrate or focus, impulsivity and hyperactivity that are inconsistent with developmental levels and that impair daily life. ADHD is the most common neurodevelopment disorder of children and persists into adulthood in at least 20% of cases. Approximately 9% of c…
  • A New Library-Search Algorithm for Mixture Analysis Using DART-MS. [Journal Article]
    J Am Soc Mass Spectrom. 2021 Jul 07; 32(7):1725-1734.Moorthy AS, Sisco E
  • Forensic analysis of seized drug evidence often involves determining whether the components of an unknown mixture are illicit compounds. One approach to this task is to screen the evidence using direct analysis in real time mass spectrometry (DART-MS) to make presumptive identifications. This manuscript introduces a new library-search algorithm that enhances presumptive identifications of mixture…
  • PET-ABC: fully Bayesian likelihood-free inference for kinetic models. [Journal Article]
    Phys Med Biol. 2021 05 20; 66(11)Fan Y, Emvalomenos G, … Meikle SR
  • Aims.We describe an intuitive, easy to use method called PET-ABC that enables full Bayesian statistical inference from single subject dynamic PET data. The performance of PET-ABC was compared with weighted non-linear least squares (WNLS) in terms of reliability of kinetic parameter estimation and statistical power for model selection.Methods.Dynamic PET data based on 1-tissue and 2-tissue compart…
  • The Use and Impact of Cognitive Enhancers among University Students: A Systematic Review. [Review]
    Brain Sci. 2021 Mar 10; 11(3)Sharif S, Guirguis A, … Schifano F
  • CONCLUSIONS: The availability of CEs for non-medical indications in different countries is influenced by a range of factors including legal, social and ethical factors. Considering the risk factors and motivations that encourage university students to use CE drugs, it is essential to raise awareness about CE-related harms, counteract myths regarding "safe" CE use and address cognitive enhancement in an early stage during education as a preventative public health measure.
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