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6,921 results
  • StatPearls: Fibrate Medications [BOOK]
    StatPearls Publishing: Treasure Island (FL) Singh Gauri G Sharda University,Greater Noida Correa Ricardo R University of Arizona BOOK
  • The fibrates are a type of amphipathic carboxylic acids, belonging to the class of drugs used to lower serum cholesterol levels. They are currently the most important class of drugs combating the worldwide epidemic of atherogenic dyslipidemia. Statins definitely help reduce the levels of low-density lipoprotein cholesterol (LDL) but do not have much effect on serum triglyceride or HDL levels, whe…
  • Formation of Amphipathic Amyloid Monolayers from Fungal Hydrophobin Proteins. [Journal Article]
    Methods Mol Biol 2020; 2073:55-72Ball SR, Pham CLL, … Sunde M
  • The fungal hydrophobins are small proteins that are able to self-assemble spontaneously into amphipathic monolayers at hydrophobic:hydrophilic interfaces. These protein monolayers can reverse the wettability of a surface, making them suitable for increasing the biocompatibility of many hydrophobic nanomaterials. One subgroup of this family, the class I hydrophobins, forms monolayers that are comp…
  • Planarity and out-of-plane vibrational modes of tryptophan and tyrosine in biomolecular modeling. [Journal Article]
    Phys Chem Chem Phys 2019Joodaki F, Martin LM, Greenfield ML
  • Tryptophan and tyrosine are amino acids that play significant roles in the folding processes of proteins at water-membrane interfaces because of their amphipathic heteroaromatic rings. Employing appropriate heteroaromatic molecular structures is essential for obtaining accurate dynamics and predictive capabilities in molecular simulations of these amino acids. In this study, molecular dynamics si…
  • Tunable Chemical Coupling in Two-Dimensional van der Waals Electrostatic Heterostructures. [Journal Article]
    ACS Nano 2019Taniguchi T, Li S, … Osada M
  • Heterostructures of two-dimensional (2D) atomic crystals provide fascinating molecular-scale design elements for emergent physical phenomena and functional materials, as integrating distinct monolayers into vertical heterostructures can afford coupling between disparate properties. However, the available examples have been limited to either van der Waals (vdW) or electrostatic (ES) heterostructur…
  • Biological Activity Of miRNA-27a Using Peptide-based Drug Delivery Systems. [Journal Article]
    Int J Nanomedicine 2019; 14:7795-7808Schachner-Nedherer AL, Werzer O, … Zimmer A
  • CONCLUSIONS: The present DDS assembled from amphipathic N-TER peptides and miRNAs is capable of inducing the anti-adipogenic effect of miRNA-27a by reducing lipid droplet accumulation in mature adipocytes. With respect to miRNA mimic replacement therapies, this approach might provide new therapeutic strategies to prevent or treat obesity and obesity-related disorders.
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