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Unbound Medicine.
(amphotericin b deoxycholate)
743 results
  • Case report: Acute Talaromyces marneffei mediastinitis in an HIV-negative patient. [Case Reports]
    Front Microbiol. 2022; 13:1045660.Chen L, Zhang M, … Zhong W
  • Talaromyces marneffei (T. marneffei) is one of the most important opportunistic human pathogens endemic in Southeast Asia. Talaromycosis, which was once regarded as an opportunistic infectious disease in patients with acquired immunodeficiency syndrome, is being increasingly reported in HIV-negative populations. Since T. marneffei infection can be localized or disseminated, patients may present w…
  • Liposomal amphotericin B-the past. [Journal Article]
    J Antimicrob Chemother. 2022 11 25; 77(Suppl_2):ii3-ii10.Brüggemann RJ, Jensen GM, Lass-Flörl C
  • The discovery of amphotericin B, a polyene antifungal compound, in the 1950s, and the formulation of this compound in a liposomal drug delivery system, has resulted in decades of use in systemic fungal infections. The use of liposomal amphotericin B formulation is referenced in many international guidelines for the treatment of fungal infections such as Aspergillus and cryptococcal disease and Ca…
  • Antifungal Combinations against Candida Species: From Bench to Bedside. [Review]
    J Fungi (Basel). 2022 Oct 13; 8(10)Fioriti S, Brescini L, … Barchiesi F
  • Candida spp. is the major causative agent of fungal infections in hospitalized patients and the fourth most common cause of nosocomial bloodstream infection (BSI). The availability of standardized methods for testing the in vitro activity of antifungals along with the expanding of antifungal armamentarium, the rising of drug-resistance and the persistence of a high mortality rate in systemic cand…
  • Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis. [Journal Article]
    mBio. 2022 Oct 12 [Online ahead of print]Giamberardino CD, Schell WA, … Shaw KJ
  • Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 inhibitor APX2039, in a mouse model of CM. Here, we investigated the efficacy of APX2039 in mouse and rabbit models of CM. In the mouse model, the controls had a mean lung fungal burden of 5.95 log10 CFU/g, whereas thos…
  • StatPearls: Amphotericin B [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)NoorAsifAWinthrop University HospitalPreussCharles V.CVUniversity of South FloridaBOOK
  • Amphotericin B deoxycholate belongs to the polyene class of antifungals. It is also known by the conventional name amphotericin B and has been used for the treatment of invasive fungal infections for more than 50 years. Newer lipid formulations that are less nephrotoxic as compared with conventional amphotericin B are available. This activity reviews the indications, contraindications, activity, …
  • Hemophagocytic Syndrome in a Patient with HIV and Histoplasmosis: A not so Rare Correlation. [Case Reports]
    Clin Pathol. 2022 Jan-Dec; 15:2632010X221118059.Freire M, Carvalho V, … Nogueira PA
  • Hemophagocytic lymphohistiocytosis (HLH) is a disorder that occurs due to unsuitable monocyte activation in a variety of infections. In human immunodeficiency virus (HIV) infections, patients with advanced immunossupression associated with opportunistic infections are at increased risk of developing HLH. We describe a clinical case of a 33-year-old male student diagnosed with HIV who was hospital…
  • Radical treatment for blastomycosis following unsuccessful liposomal amphotericin. [Case Reports]
    Lancet Infect Dis. 2022 Dec; 22(12):e377-e381.Chew C, Thapa N, … Ormenisan-Gherasim C
  • Pulmonary blastomycosis is a respiratory disease that is caused by the fungus Blastomyces spp, which is acquired through inhalation of the fungal spores. Blastomycosis is relatively uncommon, with yearly incidence rate of 1-2 cases per 100 000 people. Blastomycosis is a disease that is endemic to the midwest and southern regions of the USA, most commonly affecting immunocompromised patients. Abou…
  • Phaeohyphomycosis in China. [Review]
    Front Cell Infect Microbiol. 2022; 12:895329.He Y, Zheng HL, … Li XF
  • CONCLUSIONS: Our classifications are likely to be more practical and easier to popularize, and there are still also plenty of characteristics in these non-specific lesions. There're no significant variations in cure rates, or death rates between three grades of lesions. But patients with severe rashes have longer courses and lower effective rates.
  • Case report: Disseminated cryptococcus gattii in an immunocompetent patient. [Case Reports]
    IDCases. 2022; 29:e01537.Dreyer R
  • CONCLUSIONS: Fungal infections should be considered in any patient presenting with respiratory or neurological symptoms suggestive of Tuberculosis, pneumonia or lung carcinoma, regardless of immunocompetency. Our case highlights the importance of taking a thorough travel history in all patients, as the differential diagnosis would need to include atypical pathogens that could be endemic in the area of travel. It also highlights the significant morbidity associated with cryptococcosis and drug-related toxicities and the methods to prevent complications.
  • Treatment of Bolivian Leishmania braziliensis Cutaneous and Mucosal Leishmaniasis. [Journal Article]
    Am J Trop Med Hyg. 2022 01 24; 106(4):1182-1190.Soto J, Gutiérrez P, … Berman J
  • Although infection with Leishmania braziliensis is perhaps the key reason to treat New World cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML), the total literature contains relatively few reported cases. With the aim of supplementing the meager clinical information available, we searched the records of Jorochito (Dermatology) Hospital, Bolivia, for the years 1999-2020 and identified tr…
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