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Unbound Medicine.
(amphotericin b liposome)
4,426 results
  • Cu(II)-Triggered Ion Channel Properties of a 2,2'-Bipyridine-Modified Amphotericin B. [Journal Article]
    ACS Appl Bio Mater. 2023 Jan 28 [Online ahead of print]Komaki K, Kasuya S, … Koshiyama T
  • The development of stimuli-responsive synthetic channels that open and close in response to physical and chemical changes in the surrounding environment has attracted attention because of their potential bioapplications such as sensing, drug release, antibiotics, and molecular manipulation tools to control membrane transport in cells. Metal coordination is ideal as a stimulus for stimuli-responsi…
  • C-reactive protein interacts with amphotericin B liposomes and its potential clinical consequences. [Journal Article]
    Clin Chem Lab Med. 2023 Jan 25 [Online ahead of print]Delanghe JR, Himpe J, … Verbeke F
  • CONCLUSIONS: In vitro experiments are suggestive of a complexation between CRP and liposomes in plasma. Interpretation of CRP values following administration of AmBisome® might be impaired due to this complexation. In vivo formation of complexes between liposomes and CRP might contribute, or even lead, to intravascular microembolisation. Similar effects have been described following the administration of Intralipid® and other phosphocholine-containing liposomes.
  • Cerebral mucormycosis masquerading as brain metastasis from lung cancer: A case report. [Case Reports]
    Heliyon. 2023 Jan; 9(1):e12761.Cai Y, Wu Q, … Liu Z
  • We report a rare case of concurrent pulmonary and cerebral mucormycosis initially misdiagnosed as a metastatic tumor. A 66-year-old man with a complaint of progressive right-sided limb weakness for 3 days. Head MRI showed a left parietal occupying lesion with severe edema, and a chest CT scan showed a parenchymal mass with speculation and pleural invasion in his left lung. The patient was initial…
  • Manifestations of Mucormycosis and Its Complications in COVID-19 Patients: A Case Series Study. [Journal Article]
    Ear Nose Throat J. 2022 Dec 29 [Online ahead of print]Kordjazi M, Bazgir N, … Dilmaghani NA
  • CONCLUSIONS: SARS-CoV-2 increases the susceptibility to mucormycosis infection in various ways. Uncontrolled level of HbA1c in all patients, even non-diabetic individuals, indicates hyperglycemia over the past three months. Diabetes, orbital exenteration, ptosis, periorbital swelling, DKA, LOC, brain involvement, and mechanical ventilation all correlated with a higher rate of ICU admission and 30-day mortality. In addition, a higher white blood cell count is related to the higher probability of ICU admission. While considering all of the inflammatory laboratory data and HbA1c could help predict 30-day mortality.
  • A difficult-to-treat pleuropulmonary histoplasmosis in a patient with rheumatoid arthritis in Taiwan. [Journal Article]
    J Microbiol Immunol Infect. 2022 Dec 13 [Online ahead of print]Chu WK, Wu UI, … Chen YC
  • Amphotericin B and itraconazole are the primary agents for treating histoplasmosis. Newer azoles are alternatives for patients refractory to or intolerant of standard therapy. We report an 83-year-old woman with rheumatoid arthritis complicated with pleuropulmonary histoplasmosis who responded to liposomal amphotericin B, but progressed under voriconazole and posaconazole maintenance therapy.
  • Clinical Phenotypes of COVID-19 Associated Mucormycosis (CAM): A Comprehensive Review. [Review]
    Diagnostics (Basel). 2022 Dec 08; 12(12)Almyroudi MP, Akinosoglou K, … Dimopoulos G
  • A mucormycosis surge was reported during the COVID-19 pandemic in India. A literature search until 14 July 2022, with the aim of updating COVID-19-associated mucormycosis (CAM), identified 663 studies and 88 met inclusion criteria (8727 patients). India reported 8388 patients, Egypt 208 and Europe 40. Rhino-orbito-cerebral mucormycosis (ROCM) was identified among 8082 (98.3%) patients, followed b…
  • Otitis externa caused by Malassezia slooffiae complicated with mastoiditis: A case report. [Case Reports]
    J Infect Chemother. 2022 Nov 26 [Online ahead of print]Suga Y, Watanabe N, … Ebihara Y
  • Herein, we report a case of otitis externa caused by Malassezia slooffiae complicated with mastoiditis. A 70-year-old male complained of fever and severe otorrhea from left external auditory canal 2 months after undergoing a craniotomy to remove a hematoma. He had right-sided paralysis and undertook bed rest. Brain computed tomography revealed continuous fluid accumulation in the left mastoid air…
  • Preclinical Studies of the Nebulized Delivery of Liposomal Amphotericin B. [Journal Article]
    J Aerosol Med Pulm Drug Deliv. 2022 12; 35(6):307-312.Kothari S, Kefalos SG, … Husain S
  • Background: Intravenous liposomal amphotericin B (L-AMB) has accompanying side effects that may be diminished when administering an inhaled form. Delivery systems for inhaled or aerosolized L-AMB vary, and there has not been a recent comparison of available systems to date. Methods: We compared three differently designed nebulizer delivery systems for the inhaled delivery of L-AMB to determine th…
  • Atypical pulmonary phaeohyphomycosis due to Aureobasidium spp. - case report and brief literature review. [Case Reports]
    Swiss Med Wkly. 2022 12 06; 152:40011.Bosetti D, Spoerl D, … Neofytos D
  • We report on a case of probable invasive Auerobasidium spp. pulmonary infection in a patient with myelodysplastic syndrome. The patient was successfully treated with liposomal amphotericin B monotherapy, with transition to orally administered isavuconazole. This case shows an atypical initial radiological presentation with diffuse ground-glass opacities, as previously demonstrated in cases of Aur…
  • Amphotericin B induced pancytopenia. [Case Reports]
    J Family Med Prim Care. 2022 Sep; 11(9):5692-5695.Vaish E, Gupta KK, … Singh KK
  • Amphotericin B (AMB) has been the irreplaceable drug of choice for countless fungal and protozoal infections. One of the lesser-known adverse effects of AMB is Pancytopenia - very rare with very few cases reported - most commonly observed following prolonged administration. We report the case of a patient suffering from visceral leishmaniasis, who developed worsening pancytopenia four to five day…
  • Visceral leishmaniasis in a patient with systemic lupus erythematosus: Dilemma in diagnosis and management. [Case Reports]
    Int J Rheum Dis. 2022 Dec 11 [Online ahead of print]Akkuzu G, Ozkara S, … Bes C
  • Patients with systemic lupus erythemasus (SLE) have an increased risk of bacterial, viral, fungal or parasitic infections, especially if they are receiving immunosuppressive therapy. Leishmaniasis is a group of diseases caused by intracellular flagellate protozoan parasites belonging to the genus Leishmania. We present a 48-year-old female patient, diagnosed with SLE many years ago, who presented…
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