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Unbound Medicine.
(amyl nitrite)
954 results
  • A breath of not so fresh air…. [Case Reports]
    Breathe (Sheff). 2022 Sep; 18(3):220026.Pinto Pereira J, Hantson P, … Froidure A
  • Despite being widely used as a recreational drug, "poppers" lack a legal framework for their delivery. Their composition may vary largely. This report describes a case of severe bronchiolitis following amyl nitrite mixture inhalation.
  • Central retinal vein occlusion associated with use of amyl nitrite "poppers". [Journal Article]
    Retin Cases Brief Rep. 2022 Aug 23 [Online ahead of print]Lam A, Gulati S, … Lally DR
  • CONCLUSIONS: This is the first report of a central retinal vein occlusion associated with poppers inhalation. A high index of suspicion for poppers use should be maintained in young patients who present with vein occlusion, particularly in homosexual patients with a normal lab workup that fails to reveal a hypercoagulable etiology.
  • "Popper" induced methemoglobinemia. [Case Reports]
    Proc (Bayl Univ Med Cent). 2022; 35(3):385-386.Elgendy F, Rio-Pertuz GD, … Payne D
  • Methemoglobinemia is a blood disorder in which red blood cells contain methemoglobin, a form of hemoglobin that contains iron in its oxidized state, at levels >1%, often leading to a hypoxic state. It can be acquired or congenital and has been associated with nitrate or nitrite exposure. "Poppers" and "Rush" are slang terms given to drugs of the chemical class called amyl nitrate or isobutyl nitr…
  • Amyl Nitrite-Induced Hemolytic Anemia: Acute Therapy and Prevention. [Case Reports]
    Cureus. 2021 Jul; 13(7):e16099.Elshikh AH, Kango G, … Bawa A
  • Inhaled nitrites have been a substance of recreational use for centuries, primarily among men who have sex with men (MSM). However, there is a lack of awareness of the use of inhaled nitrites in this population and the possible complications and health disparities it carries. In this case report, we present a 62-year-old man with a past medical history of glucose-6 phosphate dehydrogenase (G6PD) …
  • Squat-to-stand provocation of dynamic left ventricular outflow tract obstruction in hypertrophic cardiomyopathy: a case report. [Case Reports]
    Eur Heart J Case Rep. 2021 Jan; 5(1):ytaa450.Peng LT, Newman DB, Geske JB
  • CONCLUSIONS: Due to the dynamic nature of LVOT obstruction, a series of provocative manoeuvres including Valsalva manoeuvre, inhalation of amyl nitrite, and exercise are often necessary to maximally augment ventricular obstruction. The recent unavailability of amyl nitrite during a nationwide shortage prompted the implementation of a protocol of repetitive squat-to-stand manoeuvre in our echocardiography laboratory. Rising from the squatting position decreases preload and afterload, both of which augment dynamic LVOT obstruction. Repetition of squatting and standing appears to enhance the sensitivity of the manoeuvre, particularly when exertional symptoms are reproduced. In this case, repetitive squat-to-stand manoeuvre led to the identification of severe LVOT obstruction which may not have been diagnosed otherwise, alteration of treatment to septal reduction therapy, and subsequent resolution of symptoms.
  • Elevated Methemoglobin Levels in a Patient Treated with Hydroxocobalamin After Suspected Cyanide Exposure. [Case Reports]
    J Emerg Med. 2020 Nov; 59(5):e157-e162.Kiernan E, Carpenter JE, … Murray BP
  • Cyanide (CN) toxicity commonly occurs during enclosed-space fires. Historically, the first step in treating CN toxicity utilized amyl nitrite and sodium nitrite to induce methemoglobinemia, which can be dangerous in this population. Hydroxocobalamin (OHCob), which binds to CN to form the nontoxic metabolite cyanocobalamin, is now the first-line antidote for CN toxicity, and has the advantage of n…
  • Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis. [Review]
    Int J Mol Sci. 2020 Apr 13; 21(8)Gori T
  • Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been the subject of a number of pharmacological approaches, particularly since when this elusive mediator was identified as one of the most important modulators of vascular homeostasis beyond vasomotion, including platele…
  • [Multifocal Electroretinography in Patients with Poppers Maculopathy]. [Journal Article]
    Klin Monbl Augenheilkd. 2019 Aug; 236(8):1004-1011.Pahlitzsch M, Salchow D, … Bergholz R
  • CONCLUSIONS: Compared to a healthy control group, the multifocal electroretinogram of patients with poppers maculopathy shows no relevant impairment. This contrasts the marked effect of the disease on visual acuity. In clinical practice, poppers maculopathy cannot be diagnosed by multifocal electroretinography.
  • Poppers: legal highs with questionable contents? A case series of poppers maculopathy. [Journal Article]
    Br J Ophthalmol. 2017 11; 101(11):1530-1534.Rewbury R, Hughes E, … Baron M
  • Poppers are volatile alkyl nitrite compounds that are inhaled to enhance sexual experience and for their psychoactive effects. A less well-known side effect is foveal maculopathy, which has emerged following changes in their chemical composition. It is unclear if certain individuals are more susceptible to retinal damage or if there is a relationship between pattern of inhalation and brands used.
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