- [TRANSLATED ARTICLE] Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]Farm Hosp. 2023 Jan 31 [Online ahead of print]FH
- CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
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- Successful treatment with anakinra in generalized spiculated porokeratosis and severe hidradenitis suppurativa in a patient with MVK and MEFV mutations. [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):161-165.CE
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- Thalidomide as an Effective Treatment in Sideroblastic Anemia, Immunodeficiency, Periodic Fevers, and Developmental Delay (SIFD). [Journal Article]
- CONCLUSIONS: Thalidomide can control the inflammation of SIFD and represents a new treatment for SIFD.
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- Describing our experience with the effects of multisystem inflammatory syndrome in children with COVID-19 on the cardiovascular system. [Journal Article]Cardiol Young. 2023 Feb 01 [Online ahead of print]CY
- Cardiac involvement with multisystem inflammatory syndrome in children can include coronary artery abnormalities, ventricular dysfunction, conduction abnormalities, arrhythmias, pericarditis, and myocarditis. We report the cardiac findings in 34 patients with multisystem inflammatory syndrome in children admitted to a single institution. We looked at patient age, sex, brain natriuretic peptide le…
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- Distinct cytokine profiles in malaria coinfections: A systematic review. [Journal Article]
- CONCLUSIONS: This systematic review provides information on distinct cytokine profiles of malaria coinfections and malaria monoinfections. Further studies should investigate whether specific cytokines for each coinfection type could serve as essential diagnostic or prognostic biomarkers for malaria coinfections.
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- Comparing biologic options for the management of Behcet's disease-related uveitis. [Journal Article]Expert Rev Clin Immunol. 2023 Jan 30 [Online ahead of print]ER
- : Behçet's disease (BD) associated uveitis occurs in approximately 50-70% of patients. Ocular involvement in BD may induce a severe affection of visual function, leading to a considerable decrease in patients' quality of life. The risk for severe visual loss increases when the ocular posterior segment is involved and in patients with no adequate treatment.
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- Comparative molecular docking analysis for analyzing the inhibitory effect of Anakinra and Ustekinumab against IL17F. [Journal Article]J Biomol Struct Dyn. 2023 Jan 30 [Online ahead of print]JB
- Interleukin 17 F is a member of IL-17 cytokine family with a 50% structural homology to IL-17A and plays a significant role either alone or in combination with IL-17A towards inflammation in Rheumatoid arthritis (RA). A growing number of drugs targeting IL-17 pathway are being tested against population specific disease markers. The major objective of this research was to investigate the anti-infl…
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- Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature. [Journal Article]
- CONCLUSIONS: Anakinra was effective and safe for management of gout flares in difficult-to-treat patients. It has been used in multiple complex scenarios, such as active infections, dialysis, transplantation, chronic kidney disease, and polyarticular gout. Anakinra has also proven effective as long-term treatment, although there are more concerns about its safety.
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- Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]Farm Hosp. 2023 Jan 27 [Online ahead of print]FH
- CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
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- Interleukin-1 receptor antagonist attenuates pro-inflammatory responses to rhinovirus in airway epithelium. [Journal Article]J Allergy Clin Immunol. 2023 Jan 25 [Online ahead of print]JA
- CONCLUSIONS: These data suggest that IL-1RA treatment significantly reduced pro-inflammatory cytokines while preserving the antiviral response. These results provide evidence for further investigation of IL-1RA as a novel targeted therapy against neutrophil-attractant cytokine release in rhinovirus-induced airway inflammatory responses.
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- High-dose intravenous anakinra treatment is safe and effective in severe and critical COVID-19 patients: a propensity score-matched study in a single center. [Journal Article]
- CONCLUSIONS: In our study, mortality was lower in patients receiving anakinra compared to SoC. Intravenous high-dose anakinra is safe and effective treatment in patients with severe and critical COVID-19.
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- Design of a multicenter randomized clinical trial for treatment of Alcohol-Associated Hepatitis. [Journal Article]Contemp Clin Trials Commun. 2023 Apr; 32:101074.CC
- CONCLUSIONS: The study provided a direct comparison of the survival benefits and safety profiles of anakinra plus zinc vs. prednisone in patients with severe AH.
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- Netherton syndrome in a Bulgarian patient : Presentation of a case and an update of therapeutic options. [Journal Article]Wien Med Wochenschr. 2023 Jan 25 [Online ahead of print]WM
- Comel-Netherton syndrome, or Netherton syndrome (NS), is a rare chronic genetic skin condition affecting the daily life of patients, which often results in poorly developed social skills and anxiety. Genetic predisposition plays a key role alongside the clinical findings, and clinicians must be aware of it as it can mimic other well-known skin conditions. Diagnosis is challenging both clinically …
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- Multisystem Inflammatory Syndrome therapies in children (MISTIC): A randomized trial. [Journal Article]
- CONCLUSIONS: This trial continues to enroll eligible participants to determine the most effective therapies in addition to IVIG and best order in which to use them to treat MIS-C.
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- Erdheim-Chester disease with Rosai-Dorfman-like lesions: treatment with methotrexate, anakinra and upadacitinib. [Case Reports]
- Erdheim-Chester disease (ECD) is a non-Langerhans cell histiocytosis characterised by clonal expansion of histiocytes in various organs. These induce an inflammatory environment, which leads to damage of the affected areas. Recently, a new disease entity was proposed encompassing key features of ECD but also of Rosai-Dorfman-Destombes disease, another histiocytosis. Mitogen-activated protein kina…
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- Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality. [Journal Article]
- CONCLUSIONS: In this large prospective study among Swedish adults, a U-shaped association between starch intake and risk of CVD and all-cause mortality was found. Several plasma proteins were identified which might provide information on potential pathways for such association. AMY1 copy number was not associated with CVD risk or any of the plasma proteins, and there was no interaction between starch intake and AMY1 copy number on disease risk.
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- Timely Resolution of SARS-CoV-2-Related Multi-System Inflammatory Syndrome in Children. [Journal Article]
- Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe, postinfectious manifestation of coronavirus disease 2019 (COVID-19) in the pediatric population. The disease is manifested by hyperinflammation and can result in cardiac dysfunction, coronary changes, and end-organ damage. Adequate timely treatment can prevent poor outcomes in the short term, but long-term data is lack…
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- Current Evidence on Vaccinations in Pediatric and Adult Patients with Systemic Autoinflammatory Diseases. [Review]
- Systemic autoinflammatory diseases (SAIDs) are defined by recurrent febrile attacks associated with protean manifestations involving joints, the gastrointestinal tract, skin, and the central nervous system, combined with elevated inflammatory markers, and are caused by a dysregulation of the innate immune system. From a clinical standpoint, the most known SAIDs are familial Mediterranean fever (F…
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- Effects of Exercise and Omega-3-Supplemented, High-Protein Diet on Inflammatory Markers in Serum, on Gene Expression Levels in PBMC, and after Ex Vivo Whole-Blood LPS Stimulation in Old Adults. [Randomized Controlled Trial]
- Inflammaging is related to cell senescence and reflects an erratic immune system, which promotes age-associated diseases. Exercise and nutrition, particularly omega-3 fatty acids, are able to affect inflammation. Therefore, we examined the effects of an 8-week exercise and dietary intervention on the inflammatory response in community-dwelling old adults. All participants received weekly vibratio…
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- Comparison of the Antiviral Activity of Remdesivir, Chloroquine, and Interferon-β as Single or Dual Agents Against the Human Beta-Coronavirus OC43. [Journal Article]
- The human beta-coronavirus strain, OC43, provides a useful model for testing the antiviral activity of various agents. We compared the activity of several antiviral drugs against OC43, including remdesivir, chloroquine, interferon (IFN)-β, IFN-λ1, and IFN-λ4, in two distinct cell types: human colorectal carcinoma cell line (HCT-8 cells) and normal human bronchial epithelial (NHBE) cells. We also …
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- Anakinra in Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [Review]
- Background: Heart failure (HF) has become increasingly difficult to manage given its increasing incidence. Despite the availability of novel treatment target relieving inhibition and congestions for neurohormonal activation, heart failure is one of leading health conditions associated with high hospitalization and readmission rates, resulting in poor quality of life. In light of this, this articl…
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- Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra. [Journal Article]Ann Clin Transl Neurol. 2023 Jan 16 [Online ahead of print]AC
- In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (six children), CRP (10 children), and serum cytokine (six children) studies, there were temporal changes in hi…
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- Efficacy of sildenafil and high-dose anakinra in an MIS-C patient with pulmonary vasculitis: A case report. [Case Reports]
- Multisystem inflammatory syndrome in children (MIS-C) is a newly identified clinical entity still not very well known in terms of epidemiology, pathogenesis, and long-term outcome. Pulmonary involvement with acute respiratory failure is an unusual life-threatening complication of MIS-C, often a reason for admission to the pediatric intensive care unit (PICU) and the use of mechanical ventilation.…
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- Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing. [Journal Article]
- CONCLUSIONS: LLLT might promote primary gingival wound healing and contribute to subsequent bone regeneration of the tooth extractions in MRONJ-like lesions via IL-1RA-mediated pro-inflammation signaling suppression.
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- Effect of interleukin-1 antagonist on growth of children with colchicine resistant or intolerant FMF. [Journal Article]
- CONCLUSIONS: Treatment with anti-IL-1 agents in children with FMF is effective and safe and may potentiate long-term growth.
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- Intravenous anakinra to curb cytokine storm in adult-onset Still's disease and in macrophage activation syndrome: A case series. [Case Reports]Joint Bone Spine. 2023 Jan 06; 90(2):105524.JB
- CONCLUSIONS: We found that administration of anakinra in patients with newly-diagnosed AOSD and/or upcoming MAS reduced hyperinflammation and prevented life-threatening complications. The IV route appears to be preferable in the hospital setting, where comorbidities such as coagulopathies and thrombocytopenia can complicate the use of other routes of administration.
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- Recurrent Lupus Pericarditis Treated with Anakinra - a Case Report. [Case Reports]ARP Rheumatol. 2022 Oct-Dec; 1(4):334-335.AR
- Comparison of Biological Agent Monotherapy and Associations Including Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis: Literature Review and Meta-Analysis of Randomized Trials. [Review]
- CONCLUSIONS: This meta-analysis confirms the superiority of combination therapy over monotherapy in rheumatoid arthritis, in accordance to the usual guidelines.
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- Anakinra for macrophage activation syndrome. [Letter]Eur J Intern Med. 2023 Jan 05 [Online ahead of print]EJ
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- CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation. [Journal Article]
- Mice with SHP1 proteins, which have a single amino acid substitution from tyrosine-208 residue to asparagine (hereafter Ptpn6spin mice), develop an autoinflammatory disease with inflamed footpads. Genetic crosses to study CD47 function in Ptpn6spin mice bred Ptpn6spin × Cd47-/- mice that were not born at the expected Mendelian ratio. Ptpn6spin bone marrow cells, when transferred into lethally irr…
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