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(anakinra)
7,147 results
  • Distinct cytokine profiles in malaria coinfections: A systematic review. [Journal Article]
    PLoS Negl Trop Dis. 2023 Jan; 17(1):e0011061.Kotepui M, Mala W, … Wilairatana P
  • CONCLUSIONS: This systematic review provides information on distinct cytokine profiles of malaria coinfections and malaria monoinfections. Further studies should investigate whether specific cytokines for each coinfection type could serve as essential diagnostic or prognostic biomarkers for malaria coinfections.
  • Comparing biologic options for the management of Behcet's disease-related uveitis. [Journal Article]
    Expert Rev Clin Immunol. 2023 Jan 30 [Online ahead of print]Vitale A, Caggiano V, … Fabiani C
  • : Behçet's disease (BD) associated uveitis occurs in approximately 50-70% of patients. Ocular involvement in BD may induce a severe affection of visual function, leading to a considerable decrease in patients' quality of life. The risk for severe visual loss increases when the ocular posterior segment is involved and in patients with no adequate treatment.
  • Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]
    Farm Hosp. 2023 Jan 27 [Online ahead of print]Ibarra Barrueta O, García Martín E, … Ais Larisgoitia A
  • CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
  • Netherton syndrome in a Bulgarian patient : Presentation of a case and an update of therapeutic options. [Journal Article]
    Wien Med Wochenschr. 2023 Jan 25 [Online ahead of print]Kordeva SA, Batashki I, Tchernev G
  • Comel-Netherton syndrome, or Netherton syndrome (NS), is a rare chronic genetic skin condition affecting the daily life of patients, which often results in poorly developed social skills and anxiety. Genetic predisposition plays a key role alongside the clinical findings, and clinicians must be aware of it as it can mimic other well-known skin conditions. Diagnosis is challenging both clinically …
  • Timely Resolution of SARS-CoV-2-Related Multi-System Inflammatory Syndrome in Children. [Journal Article]
    Viruses. 2022 Dec 29; 15(1)Reiff DD, Cron RQ
  • Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe, postinfectious manifestation of coronavirus disease 2019 (COVID-19) in the pediatric population. The disease is manifested by hyperinflammation and can result in cardiac dysfunction, coronary changes, and end-organ damage. Adequate timely treatment can prevent poor outcomes in the short term, but long-term data is lack…
  • Current Evidence on Vaccinations in Pediatric and Adult Patients with Systemic Autoinflammatory Diseases. [Review]
    Vaccines (Basel). 2023 Jan 10; 11(1)Massaro MG, Caldarelli M, … Rigante D
  • Systemic autoinflammatory diseases (SAIDs) are defined by recurrent febrile attacks associated with protean manifestations involving joints, the gastrointestinal tract, skin, and the central nervous system, combined with elevated inflammatory markers, and are caused by a dysregulation of the innate immune system. From a clinical standpoint, the most known SAIDs are familial Mediterranean fever (F…
  • Anakinra in Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [Review]
    Med Sci (Basel). 2022 Dec 26; 11(1)Mahfooz K, Rana A, … Vasavada A
  • Background: Heart failure (HF) has become increasingly difficult to manage given its increasing incidence. Despite the availability of novel treatment target relieving inhibition and congestions for neurohormonal activation, heart failure is one of leading health conditions associated with high hospitalization and readmission rates, resulting in poor quality of life. In light of this, this articl…
  • Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra. [Journal Article]
    Ann Clin Transl Neurol. 2023 Jan 16 [Online ahead of print]Lai YC, Abou-El-Kheir G, … Muscal E
  • In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (six children), CRP (10 children), and serum cytokine (six children) studies, there were temporal changes in hi…
  • CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation. [Journal Article]
    Sci Adv. 2023 01 06; 9(1):eade3942.Mazgaeen L, Yorek M, … Gurung P
  • Mice with SHP1 proteins, which have a single amino acid substitution from tyrosine-208 residue to asparagine (hereafter Ptpn6spin mice), develop an autoinflammatory disease with inflamed footpads. Genetic crosses to study CD47 function in Ptpn6spin mice bred Ptpn6spin × Cd47-/- mice that were not born at the expected Mendelian ratio. Ptpn6spin bone marrow cells, when transferred into lethally irr…
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