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2,089 results
  • Everolimus. [Journal Article]
  • RRRecent Results Cancer Res 2018; 211:101-123
  • Hasskarl J
  • Everolimus (RAD001) is an oral protein kinase inhibitor of the mTOR (mammalian target of rapamycin) serine/threonine kinase signal transduction pathway. The mTOR pathway regulates cell growth, prolif...
  • Estradiol Does Not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men. [Journal Article]
  • JEJ Endocr Soc 2018 Aug 01; 2(8):882-892
  • Roelfsema F, Yang RJ, Veldhuis JD
  • CONCLUSIONS: In this placebo-controlled prospectively randomized study, wide variations in circulating E2 did not influence lipid measures and inflammatory markers when testosterone concentrations were controlled experimentally. However, medically induced central hypogonadism in older men was accompanied by increased LDL cholesterol and metabolic cytokines, adiponectin and leptin. Abdominal visceral fat correlated strongly and positively with triglycerides, hsCRP, and leptin, but negatively with HDL.
  • Management Strategies in Opioid Abuse and Sexual Dysfunction: A Review of Opioid-Induced Androgen Deficiency. [Review]
  • SMSex Med Rev 2018 Jul 26
  • Hsieh A, DiGiorgio L, … Sadeghi-Nejad H
  • CONCLUSIONS: Because OPIAD is an underappreciated and underdiagnosed consequence of chronic opioid abuse, healthcare providers should be particularly vigilant for signs of hypogonadism in this patient population. It is reasonable for pain specialists, urologists, and primary care physicians to closely monitor patients on prescription opioids and discuss available options for treatment of hypogonadism. Hsieh A, DiGiorgio L, Fakunle M, et al. Management strategies in opioid abuse and sexual dysfunction: A review of opioid-induced androgen deficiency. Sex Med Rev 2018;XX:XXX-XXX.
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