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2,478 results
  • [A real-world study of the effects of endocrine therapy on liver function in breast cancer]. [Journal Article]
    Zhonghua Wai Ke Za Zhi. 2023 Feb 01; 61(2):107-113.Li YC, Deng ZX, … Shen SJ
  • Objective: To compare the effect of different endocrine therapy drugs on liver function in patients with early breast cancer. Methods: A retrospective cohort study was conducted to include 4 318 patients with early breast cancer who received adjuvant endocrine therapy in Department of Breast Surgery, Peking Union Medical College Hospital from January 1, 2013 to December 31, 2021. All the patients…
  • Adherence to Oral Anticancer Medications Among Women With Breast Cancer in Africa: A Scoping Review. [Review]
    JCO Glob Oncol. 2023 Jan; 9:e2100289.Onwusah DO, Ojewole EB, Chimbari MJ
  • CONCLUSIONS: The evidence mapped from studies that evaluated OAM adherence in women with BC indicates that nonadherence to OAMs is common. Applying context-specific standardized measures to assess adherence and facilitators or strategies targeting the identified barriers can optimize adherence and treatment outcomes. Effective interventions to improve adherence are limited. Therefore, further empirical and interventional studies in Africa are required to enhance the evidence.
  • Low-Grade Serous Ovarian Carcinoma: a Retrospective Study from a Tertiary Cancer Institute. [Journal Article]
    Indian J Surg Oncol. 2022 Dec; 13(4):707-715.Nuthalapati S, Kundargi RS, … Krishnappa S
  • The aim of this study was to evaluate the clinico-pathological behaviour and treatment patterns of low-grade serous carcinomas (LGSC) of ovary treated at a regional cancer centre. A retrospective analysis was done for the histopathology-proven cases of low-grade serous ovarian carcinoma, treated at a tertiary cancer institute between January, 2010, and September, 2019. There were 28 patients iden…
  • iPSCs-derived mesenchymal stromal cells mitigate anxiety and neuroinflammation in aging female mice. [Journal Article]
    Int J Biochem Cell Biol. 2023 Feb; 155:106347.Wei X, Li R, … Wang J
  • Perimenopause is a natural transition to menopause, when hormone disturbance can result in both short-term mental disorders, such as anxiety, and long-term neuroinflammation due to blood-brain barrier (BBB) impairment, which may lead to more serious neurological disorders later on, such as dementia. Effective treatments may prevent both short-term and long-term neurological sequela, which formed …
  • Update on new treatments for rare ovarian tumours. [Review]
    Curr Opin Obstet Gynecol. 2023 Feb 01; 35(1):27-33.Quesada S, Bini M, … Ray-Coquard I
  • CONCLUSIONS: The last few years have exhibited a paradigm shift towards the possibility to develop dedicated trials for ROT, owing to international collaborations supported by institutional networks. Current trials, molecular-driven and based on innovative designs, are highly promising, as they may bring ROT management towards more personalized medicine.
  • A naïve pooled data approach for extrapolation of Phase 0 microdose trials to therapeutic dosing regimens. [Journal Article]
    Clin Transl Sci. 2022 Nov 23 [Online ahead of print]van der Heijden L, van Nuland M, … Dorlo T
  • Microdosing is a strategy to obtain knowledge of human pharmacokinetics prior to Phase I clinical trials. The most frequently used method to extrapolate microdose (≤100 μg) pharmacokinetics to therapeutic doses is based on linear extrapolation from a noncompartmental analysis (NCA) with a two-fold acceptance criterion between pharmacokinetic metrics of the extrapolated microdose and the therapeut…
  • [Breast and Advanced Ovarian Double Cancer with a BRCA2 Pathogenic Variant-A Case Report]. [Case Reports]
    Gan To Kagaku Ryoho. 2022 Nov; 49(11):1271-1273.Tanaka Y, Oota R, … Suo K
  • A 49-year-old woman presented with abdominal pain. A computed tomography scan revealed a left breast mass with suspected peritoneal dissemination. She had no notable family history of the disease. Following a detailed examination, she was diagnosed with ovarian cancer(Stage ⅢC)and left breast cancer(Stage Ⅰ). After confirming the diagnosis of ovarian cancer with a laparoscopic biopsy, neoadjuvant…
  • Escitalopram co-prescription in anastrozole-treated breast cancer patients. [Journal Article]
    North Clin Istanb. 2022; 9(3):248-255.Ozyurt H, Ozden S, … Goren MZ
  • CONCLUSIONS: Escitalopram co-prescription resulted in significant increase in plasma anastrozole levels without affecting the serum estradiol levels. Our findings emphasize the need for close monitoring in case of concomitant use of anastrozole and escitalopram, especially in obese patients and the potential role of therapeutic drug monitoring.
  • The effect of aromatase inhibitors against possible testis toxicity in pembrolizumab treated rats. [Journal Article]
    Andrologia. 2022 Nov; 54(10):e14557.Türkmen NB, Çiftçi O, … Eke BC
  • Pembrolizumab is a monoclonal antibody. Anastrozole is an infertility inhibitor of aromatase. Resveratrol is an antioxidant polyphenol in the reproductive system. This study was planned to demonstrate the protective effects of anastrozole and resveratrol against pembrolizumab-induced reproductive damage. Forty-two Sprague-Dawley rats were used in the study. Groups: The control, Pembrolizumab (PEM…
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