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3,003 results
  • Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency. [Journal Article]
    Int J Endocrinol 2019; 2019:7676341Marzuki NS, Idris FP, … Batubara JRL
  • The 5-alpha-reductase type 2 deficiency (5ARD2) is an autosomal recessive condition associated with impairment in the conversion of testosterone to dihydrotestosterone. This condition leads to undervirilisation in 46,XY individuals. To date, there have been more than 100 variations identified in the gene responsible for 5ARD2 development (steroid 5-alpha-reductase 2, SRD5A2). However, few studies…
  • The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells. [Journal Article]
    Steroids 2019; 155:108556Pinacho-Garcia LM, Valdez RA, … Romano MC
  • Glioblastoma (GBM) is the most aggressive local brain tumor and effective treatments are lacking. Many studies have proposed an important participation of steroid hormones in the development of gliomas. Evidence was provided by statistics analysis where the incidence in adult population is 50% higher in men than in women. Female patients have a better prognosis for survival compared to male patie…
  • Urinary steroidomic profiles by LC-MS/MS to monitor classic 21-Hydroxylase deficiency. [Journal Article]
    J Steroid Biochem Mol Biol 2019; 198:105553Pussard E, Travers S, … Lombès M
  • 21-hydroxylase deficiency, the most common enzyme defect associated with congenital adrenal hyperplasia (CAH) is characterized by an impairment of both aldosterone and cortisol biosynthesis. Close clinical and biological monitoring of Hydrocortisone (HC) and 9α-Fludrocortisone (FDR) replacement therapies is required to achieve an optimal treatment. As frequent and repeated reassessments of plasma…
  • Urinary steroid profiling in diagnostic evaluation of an unusual adrenal mass. [Journal Article]
    Endocrinol Diabetes Metab Case Rep 2019; 2019Lenders NF, Greenfield JR
  • Adrenal oncocytomas are rare tumours, with only approximately 160 cases reported in the literature. We report the use of urinary steroid profiling as part of their diagnostic evaluation and prognostication. A 45-year-old woman presented with clinical features of hyperandrogenism. Serum biochemistry confirmed androgen excess and computed tomography (CT) demonstrated a 3.2 cm adrenal tumour with de…
  • Human Efflux Transport of Testosterone, Epitestosterone and Other Androgen Glucuronides. [Journal Article]
    J Steroid Biochem Mol Biol 2019; :105518Järvinen E, Kidron H, Finel M
  • Several drug-metabolizing enzymes are known to control androgen homeostasis in humans. UDP-glucuronosyltransferases convert androgens to glucuronide conjugates in the liver and intestine, which enables subsequent elimination of these conjugated androgens via urine. The most important androgen is testosterone, while other important ones are the testosterone metabolites androsterone and etiocholano…
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