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Unbound Medicine.
(anesthetics topical mucosal )
1,486 results
  • Polyphosphazene: A New Adjuvant Platform for Cocaine Vaccine Development. [Journal Article]
    Mol Pharm. 2022 09 05; 19(9):3358-3366.Lin M, Marin A, … Janda KD
  • Cocaine is a highly addictive drug that has seen a steady uptrend causing severe health problems worldwide. Currently, there are no approved therapeutics for treating cocaine use disorder; hence, there is an urgent need to identify new medications. Immunopharmacotherapeutics is a promising approach utilizing endogenous antibodies generated through active vaccination, and if properly programmed, c…
  • StatPearls: Diphenhydramine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)SicariVincentVKent HospitalZabboChristopher P.CPKent Hospital/ UNECOMBOOK
  • Diphenhydramine, which is available as an over-the-counter medication, is a first-generation antihistamine that is used in a variety of conditions to treat and prevent dystonias, insomnia, pruritis, urticaria, vertigo, and motion sickness. It also possesses local anesthetic properties for those patients who have allergies to other, more commonly used local anesthetics; however, this is an off-lab…
  • Green spotted puffers detect a nontoxic TTX analog odor using crypt olfactory sensory neurons. [Journal Article]
    Chem Senses. 2022 01 01; 47Suzuki T, Nakahigashi R, … Abe H
  • Toxic puffers accumulate their defense substance (tetrodotoxin; TTX) through the food chain. Although the previous study suggests that 5,6,11-trideoxyTTX, a nontoxic TTX analog detected simultaneously with TTX in toxic puffers or their prey, acts as an olfactory chemoattractant for grass puffers, it is unclear whether toxic puffers are commonly attracted to 5,6,11-trideoxyTTX, and which types of …
  • Vegetative lesions associated with inhaled cocaine use. [Letter]
    Clin Exp Dermatol. 2022 Aug; 47(8):1586-1588.Fabregat-Pratdepadua M, Del Alcázar-Viladomiu E, … Carrascosa JM
  • We present two cases of vegetating exudative lesions involving the oral mucosa, in patients that are cocaine users, with findings in biopsy and in direct immunofluorescence consistent with the diagnosis of pyostomatitis vegetans-pyodermatitis vegetans.
  • Diode Laser Light Scattering and Temperature Changes Due to Anesthesia Injection in Bovine Tongue Mucosa. [Journal Article]
    Photobiomodul Photomed Laser Surg. 2021 Sep; 39(9):587-592.Romanos GE, Tedesco RW, … Delgado-Ruiz R
  • Background and objective: Diode lasers are used in periodontal therapy. Parameters such as wavelength and application mode can affect the laser/tissue interactions, quality of incision, and final outcomes. This study set out to assess the temperature changes in tissue when diode lasers are used for incisions on tissues injected with local anesthetics. Materials and methods: Incisions were made on…
  • Cocaine-Induced Midline Destructive Lesions: A Real Challenge in Oral Rehabilitation. [Case Reports]
    Int J Environ Res Public Health. 2021 03 20; 18(6)Rampi A, Vinciguerra A, … Gastaldi G
  • Cocaine abuse is associated with severe local effects on mucosal and osteocartilaginous structures, with a centrifugal spreading pattern from the nose, a condition known as cocaine-induced midline destructive lesions (CIMDL). When the soft or hard palate is affected, a perforation may occur, with subsequent oro-nasal reflux and hypernasal speech. Both diagnosis and therapy (surgical or prosthetic…
  • Towards the advance of a novel iontophoretic patch for needle-free buccal anesthesia. [Journal Article]
    Mater Sci Eng C Mater Biol Appl. 2021 Mar; 122:111778.do Couto RO, Cubayachi C, … de Freitas O
  • The aim of this work was to develop a mucoadhesive iontophoretic patch for anesthetic delivery in the buccal epithelium. The patch was comprised of three different layers, namely i) drug release (0.64 cm2); ii) mucoadhesive (1.13 cm2); and iii) backing (1.13 cm2). Prilocaine and lidocaine hydrochlorides were used as model drugs (1:1 ratio, 12.5 mg per unit). An anode electrode (0.5 cm2 spiral sil…
  • Enhanced drug loading of in situ forming gels for oral mucositis pain control. [Journal Article]
    Int J Pharm. 2021 Feb 15; 595:120225.Li T, Lalla RV, Burgess DJ
  • Localized delivery to oral mucositis ulcerations requires specialized dosage forms, (e.g. in situ forming gels) delivered to the site in relatively low volumes. However, this is challenging for drugs with low solubility such as Bupivacaine γ-Linoleate (Bup-γL). The objective of this study is to develop an in situ forming gel with enhanced loading of Bup-γL for oral mucositis pain control. Two co-…
  • Manufacturing and characterisation of a novel composite dosage form for buccal drug administration. [Journal Article]
    Int J Pharm. 2020 Nov 15; 589:119839.Kottke D, Lura A, … Breitkreutz J
  • The potential of alternative routes of application compared to the traditional oral route is constantly growing. Especially in transmucosal applications for the oral cavity, easy accessibility is an attractive feature with many new opportunities. The combination of a minitablet and a buccal mucoadhesive carrier film has been shown to enable safe and accurate drug administration compared to semi-s…
  • Post-operative discomforts in children after extraction of primary teeth. [Journal Article]
    Clin Exp Dent Res. 2020 12; 6(6):650-658.Baillargeau C, Lopez-Cazaux S, … Renard E
  • CONCLUSIONS: About a third of the children reported pain after extraction, but the instructions for pain relief were not followed by all parents. The socioeconomic level of the young patient and the pain felt during the extraction were important predictors of discomfort. Therefore, our study could help the dentist to provide information on predicted post-operative discomfort and to allow suitable care depending on the patient's profile or procedure.
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