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(angiotensin converting enzyme ace inhibitors)
50,165 results
  • Mineralocorticoid Receptor Antagonists in Muscular Dystrophy Mice During Aging and Exercise. [Journal Article]
  • JNJ Neuromuscul Dis 2018 Jul 11
  • Lowe J, Kadakia FK, … Janssen PML
  • CONCLUSIONS: Since endogenous mineralocorticoid aldosterone production from immune cells in dystrophic muscle may explain antagonist efficacy, it is likely that these drugs work optimally during the narrow window of peak inflammation in mdx mice. Exercised and aged mdx mice do not display prolific damage and inflammation, likely explaining the absence of continued efficacy of these drugs. Since inflammation is more prevalent in DMD patients, the therapeutic window for mineralocorticoid receptor antagonists in patients may be longer.
  • Therapy of scleroderma renal crisis: State of the art. [Review]
  • ARAutoimmun Rev 2018 Jul 10
  • Zanatta E, Polito P, … Doria A
  • Scleroderma renal crisis (SRC) is an uncommon but still life-threatening manifestation of systemic sclerosis (SSc). The incidence of SRC has decreased in the last few decades, probably due to a wides...
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