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482 results
  • The evolution of recombinant thrombolytics: Current status and future directions. [Journal Article]
    Bioengineered. 2017 07 04; 8(4):331-358.Adivitiya , Khasa YP
  • Cardiovascular disorders are on the rise worldwide due to alcohol abuse, obesity, hypertension, raised blood lipids, diabetes and age-related risks. The use of classical antiplatelet and anticoagulant therapies combined with surgical intervention helped to clear blood clots during the inceptive years. However, the discovery of streptokinase and urokinase ushered the way of using these enzymes as …
  • Aspect of thrombolytic therapy: a review. [Review]
    ScientificWorldJournal. 2014; 2014:586510.Ali MR, Salim Hossain M, … Noshin TF
  • Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. In 1761, Morgagni lead the way of thrombolytic therapy. Now day's different types of thrombolytic drugs are currently available in market: alteplase, anistr…
  • Finite element modeling and experimental characterization of crosstalk in 1-D CMUT arrays. [Journal Article]
    IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Feb; 54(2):418-30.Bayram B, Kupnik M, … Khuri-Yakub BT
  • Crosstalk is the coupling of energy between the elements of an ultrasonic transducer array. This coupling degrades the performance of transducers in applications such as medical imaging and therapeutics. In this paper, we present an experimental demonstration of guided interface waves in capacitive micromachined ultrasonic transducers (CMUTs). We compare the experimental results to finite element…
  • Plasminogen activators: a comparison. [Review]
    Vascul Pharmacol. 2006 Jan; 44(1):1-9.Baruah DB, Dash RN, … Kadam SS
  • Thrombolytic drugs play a crucial role in the management of patients with acute myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis, acute thrombosis of retinal vessel, extensive coronary emboli, and peripheral vascular thromboembolism. Recognition of the importance of fibrinolytic system in thrombus resolution has resulted in the development of different fibrinol…
  • A review of the long term effects of thrombolytic agents. [Review]
    Drugs. 2000 Aug; 60(2):293-305.van Domburg RT, Boersma E, Simoons ML
  • Unequivocal evidence exists that reperfusion therapy, when given within 12 hours after onset of symptoms, saves the lives of patients with acute myocardial infarction (MI). As a result, the routine use of such treatment has increased rapidly since the mid-1980s but the rates of utilisation have been relatively static over the last decade at approximately 50% of patients with acute MI. The major q…
  • Supervision of thrombolysis of acute myocardial infarction using telemedicine. [Journal Article]
    J Telemed Telecare. 2000; 6(1):54-8.Mavrogeni SI, Tsirintani M, … Cokkinos DV
  • The treatment of acute myocardial infarction (MI) constitutes a significant problem in remote geographical areas of Greece. Furthermore, thrombolysis, the treatment of choice in the early phase of acute MI, requires the supervision of an expert. We have used thrombolytic treatment, using telemedicine, in remote medical centres. The Onassis Cardiac Surgery Centre was linked to six remote Aegean is…
  • Influence of time to treatment on early infarct-related artery patency after different thrombolytic regimens. ALKK-Study Group. [Journal Article]
    Am Heart J. 1999 Jan; 137(1):34-8.Zeymer U, Tebbe U, … Neuhaus KL
  • CONCLUSIONS: We conclude from our data that the thrombolytic efficacy of recombinant tissue-type plasminogen activator and reteplase does not decrease with the increasing interval between symptom onset and initiation of therapy. In contrast, after anisoylated plasminogen streptokinase activator complex, streptokinase, and urokinase treatment, a decrease in patency, especially TIMI-3 patency in patients treated after >3 hours after symptom onset, was observed. These results may influence the choice of the thrombolytic agent in patients who are seen >3 hours after symptom onset.
  • Audit of prehospital thrombolysis by general practitioners in peripheral practices in Grampian. [Journal Article]
    Heart. 1998 Sep; 80(3):231-4.Rawles J, Sinclair C, … Waugh N
  • CONCLUSIONS: In practices > or = 30 minutes from hospital, the BHF audit standard was readily achieved if general practitioners gave thrombolytic treatment, but not otherwise. Knowledge of the benefits of early thrombolysis, and feedback of audit results, did not lead to increased prehospital thrombolytic use. Additional incentives are required if general practitioners are to give thrombolytic treatment.
  • Prehospital management of acute myocardial infarction: Electrocardiogram acquisition and interpretation, and thrombolysis by prehospital care providers. [Review]
    Can J Cardiol. 1998 Oct; 14(10):1231-40.Myers RB
  • CONCLUSIONS: Prehospital treatment of patients with chest pain using ECGs and thrombolysis is safe. Though rural patients have significant reductions in total mortality when treated with thrombolysis in a prehospital setting, this has not been documented with an urban population. Prehospital identification of thrombolysis-eligible patients with ST elevation AMI via acquisition and interpretation of ECGs followed by triage to a hospital 'lytic team' has the potential to improve patient outcome and requires further investigation. A prehospital paramedic program for identifying and treating thrombolysis-eligible patients requires intensive planning, retrospective feasibility work, implementation and monitoring to establish effectiveness.
  • [Thrombolytic therapy]. [Review]
    Nihon Rinsho. 1998 Oct; 56(10):2577-81.Matsuda T
  • Thrombolytic therapy in patients with acute coronary syndrome is not so widely used compared to coronary intervention, such as PTCA or stenting in Japan. This is probably because of the facts that the narrowing of the coronary artery is not completely restored after the thrombolytic therapy and that the coronary intervention is frequently necessary inspite of the administration of the thrombolyti…
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