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(ankle clonus)
209 results
  • GeneReviews®: Biotin-Thiamine-Responsive Basal Ganglia Disease [BOOK]
    . University of Washington, Seattle: Seattle (WA)Adam MP, Ardinger HH, … Amemiya ATabarki B, Al-Hashem A, … Alfadhel MBOOK
  • Biotin-thiamine-responsive basal ganglia disease (BTBGD) may present in childhood, early infancy, or adulthood. The classic presentation of BTBGD occurs in childhood (age 3-10 years) and is characterized by recurrent subacute encephalopathy manifest as confusion, seizures, ataxia, dystonia, supranuclear facial palsy, external ophthalmoplegia, and/or dysphagia which, if left untreated, can eventua…
  • Hyper-reflexia in Guillain-Barré syndrome: systematic review. [Review]
    J Neurol Neurosurg Psychiatry. 2020 Mar; 91(3):278-284.Uncini A, Notturno F, Kuwabara S
  • Areflexia or hyporeflexia is a mandatory clinical criterion for the diagnosis of Guillain-Barré syndrome (GBS). A systematic review of the literature from 1 January 1993 to 30 August 2019 revealed 44 sufficiently detailed patients with GBS and hyper-reflexia, along with one we describe. 73.3% of patients were from Japan, 6.7% from the USA, 6.7% from India, 4.4% from Italy, 4.4% from Turkey, 2.2% …
  • Serotonin syndrome from sertraline monotherapy: A case report. [Case Reports]
    Am J Emerg Med. 2019 Nov 16 [Online ahead of print]Duignan KM, Quinn AM, Matson AM
  • Serotonin syndrome (SS) is a rare, potentially life-threatening adverse drug reaction. Selective serotonin reuptake inhibitors (SSRIs) are among a number of pharmaceuticals that all contribute to SS, but SS caused by SSRI monotherapy is rare. We present a case of probable sertraline-induced SS. A 36-year-old male presented to the emergency department four times in one week with a constellation of…
  • Functional Outcome of Adulthood Selective Dorsal Rhizotomy for Spastic Diplegia. [Journal Article]
    Cureus. 2019 Jul 21; 11(7):e5184.Park TS, Uhm SY, … Dobbs MB
  • Objective The medical evidence supporting the efficacy of selective dorsal rhizotomy (SDR) on children with spastic diplegia is strong. However, the outcome of SDR on adults with spastic diplegia remains undetermined. The aim is to study the effectiveness and morbidities of SDR performed on adults for the treatment of spastic diplegia. Methods Patients who received SDR in adulthood for the treatm…
  • Successful use of carbamazepine in a patient with drug rash with eosinophilia and systemic symptoms. [Case Reports]
    Ment Health Clin. 2019 Sep; 9(5):331-335.Bixby AL, Goldsborough S, … VandenBerg A
  • Drug rash with eosinophilia and systemic symptoms (DRESS) is a serious adverse drug reaction with a high mortality rate. Discontinuation of the causative agent is the primary treatment. History of DRESS may put patients at higher risk of future episodes; however, cross-reactivity between various medications is not well established. An 18-year-old African American male with a history of bipolar I …
  • Modulation of soleus stretch reflexes during walking in people with chronic incomplete spinal cord injury. [Journal Article]
    Exp Brain Res. 2019 Oct; 237(10):2461-2479.Thompson AK, Mrachacz-Kersting N, … Andersen JB
  • In people with spasticity due to chronic incomplete spinal cord injury (SCI), it has been presumed that the abnormal stretch reflex activity impairs gait. However, locomotor stretch reflexes across all phases of walking have not been investigated in people with SCI. Thus, to understand modulation of stretch reflex excitability during spastic gait, we investigated soleus stretch reflexes across th…
  • Spinal Cord Diffuse Midline Glioma in a 4-Year-Old Boy. [Case Reports]
    Child Neurol Open. 2019; 6:2329048X19842451.Kumar A, Rashid S, … Dure LS
  • CONCLUSIONS: High-grade spinal cord gliomas are very rare but should be considered in the differential diagnosis of pediatric myelopathy. Tissue biopsy is recommended in indeterminate cases to facilitate diagnosis and to guide management.
  • GeneReviews®: GTP Cyclohydrolase 1-Deficient Dopa-Responsive Dystonia [BOOK]
    . University of Washington, Seattle: Seattle (WA)Adam MP, Ardinger HH, … Amemiya AFurukawa YBOOK
  • GTP cyclohydrolase 1-deficient dopa-responsive dystonia (GTPCH1-deficient DRD) is characterized by childhood-onset dystonia and a dramatic and sustained response to low doses of oral administration of levodopa. This disorder typically presents with gait disturbance caused by foot dystonia, later development of parkinsonism, and diurnal fluctuation of symptoms (aggravation of symptoms toward the e…
  • A novel mutation of SGSH and clinical features analysis of mucopolysaccharidosis type IIIA. [Case Reports]
    Medicine (Baltimore). 2018 Dec; 97(52):e13758.Li X, Xiao R, … Huang Y
  • CONCLUSIONS: The common clinical manifestations of MPS IIIA were rapid developmental regression, seizures, cerebral atrophy, and thickened calvarial diploe. The results showed that the c.630 G > T was likely pathogenic according to bioinformatics analysis, which probably was a novel mutation. This study reports 1 case of MPS IIIA with some clinical features as determined via clinical and genetic analysis, and found a new mutation in the SGSH gene.
  • StatPearls: Clonus [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Zimmerman Barret B Rhode Island Hospital/Brown Hubbard John B. JB Wake Forest Baptist Health BOOK
  • Clonus is a rhythmic, oscillating, stretch reflex, the cause of which is not totally known; however, it relates to lesions in upper motor neurons and therefore is generally accompanied by hyperreflexia.  Therefore, clonus is used as part of the neurological physical exam to evaluate the status of a patient’s nervous system.  It can be evaluated in many joints but is most commonly seen in the ankl…
  • Development of a Clonus Management System: A Case Study of Sit-To-Stand Learning in a Stroke Patient. [Journal Article]
    Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:5958-5961.Shiraishi R, Kawamoto H, Sankai Y
  • This paper proposes a new clonus management system that integrates sit-to-stand (STS) learning with informatics and physical methods. Clonus is an involuntary muscle spasm, which often interferes with motor learning or the training of chronic patients. A conventional ankle-foot orthosis makes it difficult for patients to control the onset of clonus or to improve it. A new system with an original …
  • A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy. [Case Reports]
    Intern Med. 2019 Feb 01; 58(3):437-440.Sasaki R, Ohta Y, … Abe K
  • Klinefelter syndrome is a chromosomal disorder with a typical karyotype of 47, XXY, accompanied by various neurological symptoms. We herein report the first case of Klinefelter syndrome with a rare mosaic form of 47, XXY and 48, XXXY, combined with both spastic paraplegia and peripheral motor neuropathy. This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as …
  • Recurrent Encephalopathy During Febrile Illnesses in a 6-Year-Old Boy. [Journal Article]
    Glob Pediatr Health. 2018; 5:2333794X18784203.Szuch E, Auriemma J
  • Acute onset of encephalopathy is often due to infections or intoxications, but a high index of suspicion should exist for metabolic or autoimmune causes particularly in recurrent cases. A 6-year-old previously healthy Caucasian male presented with confusion and somnolence. He had several days of fever, myalgia, headaches, and rhinorrhea and was influenza-A positive. He was noted to have new urina…
  • A 42-year-old woman with subacute reversible dementia: A cautionary tale. [Case Reports]
    Malawi Med J. 2017 09; 29(3):265-267.Kamtchum-Tatuene J, Kamwezi R, … Kamalo P
  • A 42-year-old woman presented with a 6-month history of diffuse headache of moderate intensity and gradual onset of generalized weakness, imbalance, apathy, memory decline, hypophonia, dysphagia, constipation and urinary incontinence. Clinical examination revealed several elements of a frontal lobe dysfunction including apathy with motor impersistence, presence of primitive reflexes, generalized …
  • Effect of oral baclofen on spasticity poststroke: responders versus non-responders. [Journal Article]
    Top Stroke Rehabil. 2018 09; 25(6):438-444.Mizuno S, Takeda K, … Shigeru S
  • Objective To assess quantitatively the efficacy of oral baclofen for spasticity poststroke. Methods The participants were 29 persons poststroke with increased resistance to passive ankle dorsiflexion and ankle clonus on clinical assessment. Baclofen was administered at 20 mg/day for 1 week. The ankle joint was passively dorsiflexed at either 5°/s (slow stretch) or 90°/s (fast stretch) by a custom…
  • A case of HTLV-1 associated adult T-cell lymphoma presenting with cutaneous lesions and tropical spastic paresis. [Case Reports]
    Intractable Rare Dis Res. 2018 Feb; 7(1):61-64.Sharma PV, Witteman M, … Goldsztajn H
  • Adult T cell lymphoma (ATL), is a peripheral T cell neoplasm associated with infection by human T-lymphotropic virus (HTLV). This is a case of a 28-year-old lady who presented with back pain for the past month and recent onset weakness in her lower extremities bilaterally. She has a history of T-cell lymphoma secondary to HTLV-1 under remission since 2014 and systemic lupus erythematosus complica…
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