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(anthrax immune globulin)
784 results
  • Development of a novel multiepitope chimeric vaccine against anthrax. [Journal Article]
    Med Microbiol Immunol 2019; 208(2):185-195Aggarwal S, Somani VK, … Bhatnagar R
  • Bacillus anthracis (BA), the etiological agent of anthrax, secretes protective antigen (PA), lethal factor (LF), and edema factor (EF) as major virulence mediators. Amongst these, PA-based vaccines are most effective for providing immunity against BA, but their low shelf life limits their usage. Previous studies showed that B-cell epitopes, ID II and ID III present in PA domain IV possess higher …
  • A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague. [Journal Article]
    MBio 2018; 9(5)Tao P, Mahalingam M, … Rao VB
  • Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectively, are two of the deadliest pathogenic bacteria that have been used as biological warfare agents. Although Biothrax is a licensed vaccine against anthrax, no Food and Drug Administration-approved vaccine exists for plague. Here, we report the development of a dual anthrax-plague nanoparticle vaccine emp…
  • Improving the stability of recombinant anthrax protective antigen vaccine. [Journal Article]
    Vaccine 2018; 36(43):6379-6382Verma A, Burns DL
  • Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this study, we explored the role that two deamidation-prone Asn residues located directly adjacent to the receptor binding site of PA, Asn713 and Asn719, play i…
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