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Unbound Medicine.
(anthrax vaccine absorbed )
14 results
  • Anthrax: Where Margins are Merging between Emerging Threats and Bioterrorism. [Journal Article]
    Indian J Dermatol. 2017 Sep-Oct; 62(5):456-458.Banerjee D, Chakraborty B, Chakraborty B
  • National Institute of Allergy and Infectious Diseases has classified all the emerging infectious diseases agents under three categories. Among Category A priority pathogens comes Bacillus anthracis -the causative agent of Anthrax. It is a gram positive spore bearing bacteria, and the disease is typically associated with grazing animals, and affects the people as a zoonosis. The disease can be cla…
  • Stability and pre-formulation development of a plant-produced anthrax vaccine candidate. [Journal Article]
    Vaccine. 2017 10 04; 35(41):5463-5470.Jones RM, Burke M, … Yusibov V
  • Second generation anthrax vaccines focus on the use of recombinant protective antigen (rPA) to elicit a strong, toxin neutralizing antibody responses in immunized subjects. The main difference between the rPA vaccines compared to the current licensed vaccine, anthrax vaccine absorbed (AVA), is the rPA vaccines are highly purified preparations of only rPA. These second generation rPA vaccines stri…
  • Progress toward the Development of a NEAT Protein Vaccine for Anthrax Disease. [Journal Article]
    Infect Immun. 2016 Dec; 84(12):3408-3422.Balderas MA, Nguyen CT, … Maresso AW
  • Bacillus anthracis is a sporulating Gram-positive bacterium that is the causative agent of anthrax and a potential weapon of bioterrorism. The U.S.-licensed anthrax vaccine is made from an incompletely characterized culture supernatant of a nonencapsulated, toxigenic strain (anthrax vaccine absorbed [AVA]) whose primary protective component is thought to be protective antigen (PA). AVA is effecti…
  • The early humoral immune response to Bacillus anthracis toxins in patients infected with cutaneous anthrax. [Journal Article]
    FEMS Immunol Med Microbiol. 2011 Jul; 62(2):164-72.Brenneman KE, Doganay M, … Baillie LW
  • Bacillus anthracis, the causative agent of anthrax, produces a tripartite toxin composed of two enzymatically active subunits, lethal factor (LF) and edema factor (EF), which, when associated with a cell-binding component, protective antigen (PA), form lethal toxin and edema toxin, respectively. In this preliminary study, we characterized the toxin-specific antibody responses observed in 17 indiv…
  • Vaccines for preventing anthrax. [Review]
    Cochrane Database Syst Rev. 2009 Apr 15Donegan S, Bellamy R, Gamble CL
  • CONCLUSIONS: One cluster-RCT provides limited evidence that a live-attenuated vaccine is effective in preventing cutaneous anthrax. Vaccines based on anthrax antigens are immunogenic in most vaccinees with few adverse events or reactions. Ongoing randomized controlled trials are investigating the immunogenicity and safety of anthrax vaccines.
  • Anthrax vaccines: Pasteur to the present. [Historical Article]
    Cell Mol Life Sci. 2006 Oct; 63(19-20):2237-48.Scorpio A, Blank TE, … Chabot DJ
  • Anthrax has been a major cause of death in grazing animals and an occasional cause of death in humans for thousands of years. Since the late 1800s there has been an exceptional international history of anthrax vaccine development. Due to animal vaccinations, the rate of infection has dropped dramatically. Anthrax vaccines have progressed from uncharacterized whole-cell vaccines in 1881, to pXO2-n…
  • Validation of the anthrax lethal toxin neutralization assay. [Journal Article]
    Biologicals. 2004 Mar; 32(1):17-27.Hering D, Thompson W, … Pace-Templeton J
  • A validation of the performance characteristics of a toxin neutralization assay is presented. This in vitro assay measures the functional ability of antisera, containing antibodies to anthrax lethal toxin, to specifically protect J774A.1 cells against Bacillus anthracis lethal toxin cytotoxicity. This colormetric assay is based upon the reduction of MTT by living cells. Human and rabbit antisera …
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