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(anti alzheimers agents)
2,594 results
  • Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments. [Journal Article]
    Biochim Biophys Acta Gen Subj 2019; :129467Balmik AA, Das R, … Chinnathambi S
  • Tau is the major neuronal protein involved in the stabilization of microtubule assembly. In Alzheimer's disease, Tau self-assembles to form intracellular protein aggregates which are toxic to cells. Various methods have been tried and tested to restrain the aggregation of Tau. Most of the agents tested for this purpose have limitations in their effectiveness and availability to neuronal cells. We…
  • Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges. [Review]
    Front Cell Dev Biol 2019; 7:235Chen Z, Downing S, Tzanakakis ES
  • Regenerating islet-derived (Reg) proteins have emerged as multifunctional agents with pro-proliferative, anti-apoptotic, differentiation-inducing and bactericidal properties. Over the last 40 years since first discovered, Reg proteins have been implicated in a gamut of maladies including diabetes, various types of cancer of the digestive tract, and Alzheimer disease. Surprisingly though, a consen…
  • Inhibitors of Cholinesterases in the Pharmacology, the Current Trends. [Journal Article]
    Mini Rev Med Chem 2019Pohanka M
  • Inhibitors of cholinesterases are a wide group of chemical compounds with a significant role in pharmacology. Beside the pharmacological purpose, they are also known as toxic compounds and military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Beside this, anti-inflammat…
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