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(antibody combining site)
30,120 results
  • Distinguishing Features of Cetuximab and Panitumumab in Colorectal Cancer and Other Solid Tumors. [Review]
    Front Oncol 2019; 9:849García-Foncillas J, Sunakawa Y, … Stintzing S
  • Cetuximab and panitumumab are two distinct monoclonal antibodies (mAbs) targeting the epidermal growth factor receptor (EGFR), and both are widely used in combination with chemotherapy or as monotherapy to treat patients with RAS wild-type metastatic colorectal cancer. Although often considered interchangeable, the two antibodies have different molecular structures and can behave differently in c…
  • [Principles and basics of immunohistochemistry]. [Journal Article]
    Nihon Yakurigaku Zasshi 2019; 154(4):156-164Ozawa H
  • Immunohistochemistry is a widely used technique, which visualize and observe specific substances present in cells, tissues, organs, and individuals, in many research field applying various and specific molecular recognition mechanisms that exist in the living body, so called antibody-antigen reaction. Morphology is what observes using a microscope such as light microscope, electron microscope, fl…
  • Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV. [Journal Article]
    Nat Med 2019Ehrhardt SA, Zehner M, … Klein F
  • Recombinant vesicular stomatitis virus-Zaire Ebola virus (rVSV-ZEBOV) is the most advanced Ebola virus vaccine candidate and is currently being used to combat the outbreak of Ebola virus disease (EVD) in the Democratic Republic of the Congo (DRC). Here we examine the humoral immune response in a subset of human volunteers enrolled in a phase 1 rVSV-ZEBOV vaccination trial by performing comprehens…
  • Yeast surface display of full-length human microtubule-associated protein tau. [Journal Article]
    Biotechnol Prog 2019; :e2920Wang S, Cho YK
  • Microtubule-associated protein tau is an intrinsically disordered, highly soluble protein found primarily in neurons. Under normal conditions, tau regulates the stability of axonal microtubules and intracellular vesicle transport. However, in patients of neurodegeneration such as Alzheimer's disease (AD), tau forms neurofibrillary deposits, which correlates well with the disease progression. Iden…
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