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(antifungals topical )
7,815 results
  • Prevention of acquired invasive fungal infection with decontamination regimen in mechanically ventilated ICU patients: a pre/post observational study. [Journal Article]
    Infect Dis (Lond). 2023 Jan 24 [Online ahead of print]Massart N, Reizine F, … Fillatre P
  • CONCLUSIONS: Acquired fungal infection is a rare event, but accounts for a large proportion of ICU-acquired infections. Our study showed a preventive effect of decontamination against acquired fungal infection, especially candidemia.Take home messageAcquired fungal infection (AFI) incidence is close to 4% in mechanically ventilated patients without antifungal prophylaxis (3% for pulmonary aspergillosis and 1% for candidemia).Aspergillosis accounts for 14% of ventilator-associated pneumonia and candidemia for 9% of acquired bloodstream infections.Immunocompromised patients, those infected with SARS-COV 2 or influenza virus, males and patients admitted during the fall season are at higher risk of AFI.Mechanically ventilated patients receiving multiple site decontamination (MSD) have a lower risk of AFI.
  • Nocardia arthritidis scleritis: A case report. [Case Reports]
    Am J Ophthalmol Case Rep. 2023 Mar; 29:101794.Abdelmegid O, Thakur S, Cheung AY
  • CONCLUSIONS: This unique case demonstrates infectious scleritis caused by an uncommon Nocardia species (N. arthritidis) that was successfully treated with similar strategies used for other reported Nocardia species. As Nocardia scleritis can lead to adverse outcomes if not treated promptly and properly, it should be considered on the differential diagnoses in an immunocompromised patient who presents with acute ocular symptoms after any recent ocular surgery.
  • Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections. [Review]
    Pharmaceutics. 2023 Jan 12; 15(1)de Almeida Campos L, Fin MT, … Mendes-Giannini MJS
  • Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant…
  • First Report of Neocucurbitaria unguis-hominis Keratitis. [Case Reports]
    J Fungi (Basel). 2022 Dec 21; 9(1)Sáenz-Madrazo N, Baeza A, … Urcelay JL
  • Coelomycetous fungi are among the emerging causes of infections and have been involved in many kinds of infections, including keratitis and endophtalmitis. Here, we present the first case of keratitis caused by Neocucurbitaria unguis-hominis, a coelomycetous fungus belonging to the family Cucurbitariaceae. In this case report, we describe the clinical presentation of a 56-year-old woman, a regula…
  • Performance of Two Extracts Derived from Propolis on Mature Biofilm Produced by Candida albicans. [Journal Article]
    Antibiotics (Basel). 2022 Dec 31; 12(1)Barros ILE, Veiga FF, … Svidzinski TIE
  • Species of the Candida genus represent the third most common cause of onychomycosis, the most frequent and difficult to treat nail infection. Onychomycosis has been attributed to fungi organized in biofilm and some natural products have proved promising for its treatment. This study aimed to evaluate the antibiofilm activity of propolis extract (PE) and its by-product (WPE) on 7-day preformed bio…
  • Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age. [Journal Article]
    Med Mycol. 2022 Dec 29; 61(1)Jayawardena-Thabrew H, Warris A, … Ferreras-Antolin L
  • The indications for nystatin as prophylaxis or treatment are limited. In the PASOAP (Pediatric Antifungal Stewardship Optimizing Antifungal Prescription) study, high use of nystatin in hospitalized children beyond the neonatal age was observed. In this report, we present the data on nystatin use in infants and children ≥ 3 months who participated in the PASOAP study. Nystatin was prescribed mainl…
  • Use of mTOR inhibitors (rapalogs) for the treatment of skin changes in tuberous sclerosis complex. [Review]
    Arch Pediatr. 2022 Dec; 29(5S):5S20-5S24.Farges D, Sigg N, … Martin L
  • CONCLUSIONS: The issues of cost and access to affordable topical rapamycin formulations are critical for the patients even if skin changes do not cause serious harm in the context of TSC. We strongly suggest to improve and standardize the formulation of topical rapamycin, to encourage the pharmaceutical industry for providing commercial products, and the Health systems (social welfare) to reimburse them. © 2022 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
  • Efficacy of a Silver-Based Shampoo for Treatment of Canine Malassezia: A Pilot Study. [Journal Article]
    J Am Anim Hosp Assoc. 2023 Jan 01; 59(1):7-11.Jones S, Bloom P
  • Malassezia pachydermatis is a commensal of canines associated with Malassezia dermatitis. Consensus guidelines recommend topical and/or systemic treatment, but resistance to antifungals has been reported. The objective of this pilot study was to determine the efficacy of a 0.003% colloidal silver nanoparticle-based shampoo in the treatment of canine Malassezia dermatitis. Dogs were included based…
  • Age-Related Differences in the Clinical Patterns of Ocular Graft-Versus-Host Disease. [Journal Article]
    Turk J Ophthalmol. 2022 12 28; 52(6):366-373.Altan-Yaycıoğlu R, Aydın Akova Y, Dönmez O
  • CONCLUSIONS: In ocular GVHD, conjunctival cicatrization and limbal stem cell deficiency might be observed more often in adults. Topical cyclosporine, autologous/allogenic serum drops, and punctal plugs are helpful in moderate or more severe cases. With early diagnosis and treatment, an improvement in clinical signs and visual acuity might be observed, particularly in younger patients.
  • Unmet needs for patients with seborrheic dermatitis. [Review]
    J Am Acad Dermatol. 2022 Dec 17 [Online ahead of print]Jackson JM, Alexis A, … Taylor S
  • Seborrheic dermatitis (SD) is a common skin disease with signs and symptoms that may vary by skin color, associated medical conditions, environmental factors, and vehicle preference. Diagnosis of SD is based on presence of flaky, "greasy" patches, and/or thin plaques accompanied by erythema of the scalp, face, ears, chest, and groin and is associated with pruritus in many patients. The presentati…
  • Otitis externa caused by Malassezia slooffiae complicated with mastoiditis: A case report. [Case Reports]
    J Infect Chemother. 2022 Nov 26 [Online ahead of print]Suga Y, Watanabe N, … Ebihara Y
  • Herein, we report a case of otitis externa caused by Malassezia slooffiae complicated with mastoiditis. A 70-year-old male complained of fever and severe otorrhea from left external auditory canal 2 months after undergoing a craniotomy to remove a hematoma. He had right-sided paralysis and undertook bed rest. Brain computed tomography revealed continuous fluid accumulation in the left mastoid air…
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