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Unbound Medicine.
(antifungals vaginal )
2,956 results
  • A Review of Studies on Candida Species in Peninsular Malaysia. [Review]
    Adv Biomed Res. 2022; 11:98.Farooq H, Monowar T, … Sabesan GS
  • Data on the epidemiology and the antifungal susceptibility of Candida species infections in Malaysia is still limited. The study aimed to review and compare studies reporting the prevalence of Candida species and antifungal susceptibility of Candida infections in Peninsular Malaysia. Data from 22 studies published between 2009 and 2018. Data was collected using National Center for Biotechnology I…
  • α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa. [Journal Article]
    Carbohydr Polym. 2023 Feb 15; 302:120420.Costa RHF, Krawczyk-Santos AP, … Gratieri T
  • This work aimed to evaluate poly(pseudo)rotaxanes (PPRs) potential for vaginal antifungal delivery. For this, PPRs containing terbinafine (TB) 2 % were obtained using two small surfactants, Kolliphor® RH40 and Gelucire® 48/16, and different α-cyclodextrin (α-CD) concentrations (5 and 10 %). PPRs were characterized by their physicochemical characteristics, irritation, and mucoadhesion capabilities…
  • Nanocellulose-gellan cross-linked scaffolds for vaginal delivery of fluconazole. [Journal Article]
    Int J Biol Macromol. 2022 Dec 30; 229:668-683.Pahwa R, Ahuja M
  • The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system. The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental d…
  • Clinical and morphopathological assay in vulvovaginal candidiasis. [Journal Article]
    Rom J Morphol Embryol. 2022 Jul-Sep; 63(3):511-520.Manolea MM, Istrate-Ofiţeru AM, … Siminel MA
  • Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species. The purpose of this study was to analyze and compare the clinical, microbiological, and histopathological aspects of pregnant and non-pregnant patients, symptomatic or asymptomatic in the case of candida vaginitis and to correlate the …
  • Advanced Solid Formulations For Vulvovaginal Candidiasis. [Review]
    Pharm Res. 2022 Nov 30 [Online ahead of print]Conte J, Parize AL, Caon T
  • Vulvovaginal candidiasis (VVC) is an opportunistic and endogenous infection caused by a fungus of the Candida genus, which can cause pruritus, dysuria, vulvar edema, fissures and maceration of the vulva. The treatment of vaginal candidiasis is carried out mainly by antifungal agents of azole and polyene classes; however, fungal resistance cases have been often observed. For this reason, new thera…
    Georgian Med News. 2022 SepFedorych P, Kuts T, Koval S
  • Objective - to determine the sensitivity of Gardnerella vaginalis to fenticonazole to justify the feasibility of using this mainly antifungal drug for local treatment of BV in cases when it is a multifactorial disease caused by Gardnerella vaginalis and Candida spp. simultaneously.; We observed 98 women with infections of the urogenital tract at the ages of 20 to 49. At the first stage of the stu…
  • In the search for appropriateness in the cure of vaginitis: a model of anti-fungal stewardship? [Review]
    Eur Rev Med Pharmacol Sci. 2022 10; 26(20):7713-7718.Tumietto F, Sora E, Tedeschi S
  • Antimicrobial resistance remains a worldwide issue with a major clinical and economic impact, leading to exceeding mortality, increased frequency of hospitalization and a great burden on the healthcare systems. Vulvovaginitis, especially when due to mixed infections, has emerged as a condition for which appropriate selection of antimicrobial therapy and proper antimicrobial stewardship programs (…
  • Vaginal Lactobacillus Impair Candida Dimorphic Switching and Biofilm Formation. [Journal Article]
    Microorganisms. 2022 Oct 21; 10(10)Parolin C, Croatti V, … Vitali B
  • Lactobacillus spp. generally dominate the vaginal microbiota and prevent pathogen adhesion and overgrowth, including Candida spp., by various mechanisms. Although Candida spp. can be commensal, in certain conditions they can become pathogenic, causing vulvovaginal candidiasis. The insurgence of candidiasis is related to the expression of Candida virulence factors, including morphologic switching …
  • Comparison of Virtual Management of Vulvovaginal Candidiasis to Traditional In-Person Care. [Journal Article]
    Telemed J E Health. 2022 Oct 11 [Online ahead of print]Murray MA, Penza KL, … Pecina JL
  • Objective: Compare demographics, treatment, and follow-up rates for patients with complaints of vulvovaginitis suggestive of candida infection evaluated via e-visit, face-to-face (F2F) visits, or nurse-administered phone protocol. Methods: Manual review of 150 vaginitis visits of each visit type (e-visit, F2F, and phone protocol) completed between May 5, 2018 through January 31, 2020 by Mayo Clin…
  • Vulvovaginal candidiasis in Iranian women: Molecular identification and antifungal susceptibility pattern. [Journal Article]
    J Obstet Gynaecol Res. 2022 Dec; 48(12):3292-3303.Khaksar Baniasadi A, Ayatollahi Mosavi SA, … Agha Kuchak Afshari S
  • CONCLUSIONS: This study demonstrated that the majority of VVC cases were caused by non-albicans Candida species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of Candida species isolated from VVC patients.
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