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42,374 results
  • StatPearls: Avian Influenza [BOOK]
    StatPearls Publishing: Treasure Island (FL) Sendor Adam B. AB Wellstar Kennestone Regional Med Center Weerasuriya Dilani D Kennestone Hospital Sapra Amit A Southern Illinois University BOOK
  • Because infection with avian influenza can be particularly deadly in comparison to other viruses, practitioners may not be aware of the extra caution required when evaluating possible cases of infection. This article will impress on practitioners the severity of the disease and the need for high suspicion in specific scenarios as well as the need for early escalation of care. Avian influenza is a…
  • Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity. [Journal Article]
    Mol Ther Methods Clin Dev 2020; 17:209-219Ferreira CB, Sumner RP, … Towers GJ
  • Most gene therapy lentiviral vector (LV) production platforms employ HEK293T cells expressing the oncogenic SV40 large T-antigen (TAg) that is thought to promote plasmid-mediated gene expression. Studies on other viral oncogenes suggest that TAg may also inhibit the intracellular autonomous innate immune system that triggers defensive antiviral responses upon detection of viral components by cyto…
  • Target Alpha Therapy with Thorium-227. [Journal Article]
    Cancer Biother Radiopharm 2020Frantellizzi V, Cosma L, … De Vincentis G
  • Targeted alpha therapy (TAT) can deliver high localized burden of radiation selectively to cancer cells as well as the tumor microenvironment, while minimizing toxicity to normal surrounding cell. Radium-223 (223Ra), the first-in-class a-emitter approved for bone metastatic castration-resistant prostate cancer has shown the ability to prolong patient survival. Targeted Thorium-227 (227Th) conjuga…
  • Dormant tumor cells interact with memory CD8+ T cells in RET transgenic mouse melanoma model. [Journal Article]
    Cancer Lett 2020Flores-Guzmán F, Utikal J, Umansky V
  • Melanoma is an aggressive form of skin-cancer. Melanoma cells are characterized by their plasticity, resulting in therapy resistance. Using RET transgenic mouse melanoma model, we characterized dormant tumor cells accumulated in the bone marrow (BM) and investigated their interaction with effector memory CD8+ T cells. We found that cells expressing melanoma-associated antigen tyrosinase related p…
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