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17,718 results
  • Selection and Characterization of Anti-idiotypic Shark Antibody Domains. [Journal Article]
    Methods Mol Biol 2020; 2070:191-209Könning D, Zielonka S, … Schröter C
  • The antibody repertoire of cartilaginous fish comprises an additional heavy-chain-only antibody isotype that is referred to as IgNAR (immunoglobulin novel antigen receptor). Its antigen-binding site consists of one single domain (vNAR) that is reportedly able to engage a respective antigen with affinities similar to those achieved by conventional antibodies. While vNAR domains offer a reduced siz…
  • StatPearls: Coombs Test [BOOK]
    StatPearls Publishing: Treasure Island (FL) Theis Samuel R. SR Wright-Patterson AFB / Wright State Hashmi Muhammad F. MF College of Physicians and Surgeons BOOK
  • Antiglobulin testing, also known as the Coombs test, is an immunology laboratory procedure used to detect the presence of antibodies against circulating red blood cells (RBCs) in the body, which then induce hemolysis. The destruction of these red blood cells (RBCs) by antibodies directed against them is described diagnostically as autoimmune hemolytic anemia (AIHA). Many etiologies fall under thi…
  • [Progress in diagnosis and treatment of autoimmune hemolytic anemia]. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1100-1107Kamesaki T
  • In 2017, The British Society of Haematology published new guidelines for the diagnosis and management of autoimmune hemolytic anemia (AIHA). Usually this is diagnosed using a combination of clinical and laboratory findings of hemolysis using the direct antiglobulin test (DAT). The revised guidelines propose several steps to evaluate and diagnose patients with unexplained hemolysis and a negative …
  • Immunogenicity of Innovative and Biosimilar Monoclonal Antibodies. [Review]
    Antibodies (Basel) 2019; 8(1)Doevendans E, Schellekens H
  • The development of hybridoma technology for producing monoclonal antibodies (mAbs) by Kohler and Milstein (1975) counts as one of the major medical breakthroughs, opening up endless possibilities for research, diagnosis and for treatment of a whole variety of diseases. Therapeutic mAbs were introduced three decades ago. The first generation of therapeutic mAbs of murine origin showed high immunog…
  • Changes of Serum IgG Dimer Levels after Treatment with IVIg in Guillain-Barré Syndrome. [Journal Article]
    J Neuroimmune Pharmacol 2019Svačina MKR, Röth P, … Lehmann HC
  • Intravenous immunoglobulins (IVIg) are standard treatment for Guillain-Barré syndrome (GBS). Their exact mechanisms of action are versatile and not fully understood. One possible mechanism is neutralization of circulating autoantibodies via binding to anti- idiotypic antibodies forming idiotype-anti-idiotype dimeric IgG immune complexes. To examine the role of immune complex formation as mechanis…
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